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Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats

International Journal of Obesity volume 26, pages 573–576 (2002)Cite this article

Abstract

BACKGROUND AND OBJECTIVE: Comparative studies have shown that Wistar Ottawa Karlsburg W (RT1u) rats (WOKW) develop a nearly complete metabolic syndrome with obesity, moderate hypertension, dyslipidemia, hyperinsulinemia, and impaired glucose tolerance up to an age of 28 weeks. Because metabolic data thereafter are missing, WOKW and disease-resistant DA rats were studied for 12 months beginning at an age of 5 months.

METHODS: Eighteen male inbred WOKW and DA rats were studied monthly from the 5th to the 17th month of life for traits of the metabolic syndrome such as body weight, body mass index (BMI), serum triglycerides, total cholesterol, leptin, insulin as well as glucose tolerance, 24 h excretion of urine total protein and creatinine including telemetric measurement of blood pressure in six males per each group.

RESULTS: Except for serum total cholesterol, the measured values for most traits studied were significantly higher in WOKW than in DA rats at an age of 5 months. At an age of 17 months all traits were significantly elevated in WOKW compared with DA rats. WOKW rats were hypertensive, dyslipidemic, obese, glucose intolerant, hyperinsulinemic and proteinuric.

CONCLUSION: Considering the phenotype of the WOKW rat described until now and the fact that the metabolic syndrome in this rat is polygenetically determined, the WOKW rat is the most suitable animal model to study the pathophysiology of the facets of the syndrome.

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Acknowledgements

The authors wish to thank Edeltraut Lübke and Kathrin Stabenow for excellent technical assistance. This work was supported by grant no. KL 771/3-3 of Deutsche Forschungsgemeinschaft.

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  1. Department of Laboratory Animal Science, Medical Faculty, University of Greifswald, Karlsburg, Germany

    J van den Brandt, P Kovacs & I Klöting

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  1. J van den Brandt
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Correspondence to I Klöting.

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van den Brandt, J., Kovacs, P. & Klöting, I. Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats. Int J Obes 26, 573–576 (2002). https://doi.org/10.1038/sj.ijo.0801966

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