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CO2 production during acute infection in malnourished Malawian children

European Journal of Clinical Nutrition volume 58, pages 116–120 (2004)Cite this article

Abstract

Objective: This study tested the hypotheses that the rate of CO2 production is less in marasmic children with acute infection when compared to well-nourished children, but greater when compared to uninfected marasmic children.

Design: A descriptive comparison of children aged 12–60 months who had their rates of CO2 production measured using a stable isotope tracer dilution method while receiving feedings. Body mass index (BMI) was the best measure of lean body mass available in this study.

Setting: Queen Elizabeth Central Hospital, Blantyre, Malawi.

Subjects: A total of 56 children were studied, 28 with marasmus and acute infection, 16 with marasmus, and 12 well nourished with acute infection. Those with acute infection had malaria, pneumonia, or sepsis.

Results: Well-nourished children with acute infection produced more CO2 than marasmic children (344±60 vs 225±65 mmol CO2/h, mean±s.d., P<0.001; 24.2±4.6 vs 18.4±5.4 mmol CO2/BMI h, P=0.001). However, the rate of CO2 production in marasmic children with acute infection was not greater than in uninfected marasmic children (225±65 vs 228±61 mmol CO2/h). The observed rate of CO2 production was greater than that which could be produced from the dietary intake alone (29.6 vs. 25.8 mmol CO2/kg h).

Conclusions: Marasmic children do not increase energy expenditure in response to acute infection, as well-nourished children do. Dietary energy provided to marasmic children should be at least 420 kJ/kg day.

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Authors and Affiliations

  1. Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA

    M J Manary

  2. Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA

    K E Yarasheski & R Berger

  3. College of Medicine, University of Malawi, Blantyre, Malawi

    R L Broadhead

Authors
  1. M J Manary
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  2. K E Yarasheski
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  3. R Berger
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  4. R L Broadhead
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Contributions

Guarantor: MJ Manary

Contributors: MJM designed the study, enrolled and followed the children, analyzed the data and wrote the manuscript. KEY designed the study, performed the laboratory analyses, analyzed the data and wrote the manuscript. RB performed the laboratory analyses and wrote the manuscript. RLB enrolled and followed the children and wrote the manuscript. None of the authors have any potential conflicts of interest.

Sponsorship: Supported by National Institutes of Health (RO1HD38422), the Washington University Biomedical Mass Spectrometry Facility (NIH RR00954), and Clinical Nutrition Research Unit (NIH P30 DK56341).

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Correspondence to M J Manary.

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Manary, M., Yarasheski, K., Berger, R. et al. CO2 production during acute infection in malnourished Malawian children. Eur J Clin Nutr 58, 116–120 (2004). https://doi.org/10.1038/sj.ejcn.1601757

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