Phagocytes may engulf both apoptotic and viable cells via calreticulin on the surface of the target cell, through its interaction with the phagocyte receptor, LRP. In reality, however, only apoptotic cells are engulfed, apparently because their surface ligand CD47 is prevented from activating the inhibitory phagocyte receptor SIRPα.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Head and neck tumor cells treated with hypofractionated irradiation die via apoptosis and are better taken up by M1-like macrophages
Strahlentherapie und Onkologie Open Access 19 October 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Savill, J., Dransfield, I., Gregory, C. D. & Haslett, C. Nature Rev. Immunol. 2, 965–975 (2002).
Gregory, C. D. & Devitt, A. Immunology 113, 1–14 (2004).
Fadok, V. A., Bratton, D. L., Guthrie, L. & Henson, P. M. J. Immunol. 166, 6847–6854 (2001).
Gardai, S. J. et al. Cell 123, 321–34 (2005).
Fadok, V. A. et al. J. Immunol. 148, 2207–2216 (1992).
Heal, R. & McGivan, J. Biochem J. 329, 389–394 (1998).
Ogden, C. A. et al. J. Exp. Med. 194, 781–795 (2001).
Grimsley, C. & Ravichandran, K. S. Trends Cell Biol. 13, 648–56 (2003).
Moffatt, O. D., Devitt, A., Bell, E. D., Simmons, D. L. & Gregory, C. D. J. Immunol. 162, 6800–6810 (1999).
Brown, S. et al. Nature 418, 200–203 (2002).
Savill, J., Hogg, N., Ren, Y. & Haslett, C. J. Clin. Invest. 90, 1513–1522 (1992).
Oldenborg, P. A. et al. Science 288, 2051–2054 (2000).
Ravetch, J. V. & Lanier, L. L. Science 290, 84–89 (2000).
Oldenborg, P. A., Gresham, H. D. & Lindberg, F. P. J. Exp. Med. 193, 855–862 (2001).
Tada, K. et al. J. Immunol. 171, 5718–5726 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gregory, C., Brown, S. Apoptosis: eating sensibly. Nat Cell Biol 7, 1161–1163 (2005). https://doi.org/10.1038/ncb1205-1161
Issue Date:
DOI: https://doi.org/10.1038/ncb1205-1161
This article is cited by
-
Head and neck tumor cells treated with hypofractionated irradiation die via apoptosis and are better taken up by M1-like macrophages
Strahlentherapie und Onkologie (2022)
-
Argonaute proteins: functional insights and emerging roles
Nature Reviews Genetics (2013)
-
Small silencing RNAs: an expanding universe
Nature Reviews Genetics (2009)
-
Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor
Nature Neuroscience (2009)
-
Optimization of immunoprecipitation–western blot analysis in detecting GW182-associated components of GW/P bodies
Nature Protocols (2009)