Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.
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Tomimatsu, K., Narita, M. Translating the effects of mTOR on secretory senescence. Nat Cell Biol 17, 1230–1232 (2015). https://doi.org/10.1038/ncb3244
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DOI: https://doi.org/10.1038/ncb3244
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