Abstract
Membrane trafficking and mitosis are two essential processes in eukaryotic cells. Surprisingly, many proteins best known for their role in membrane trafficking have additional 'moonlighting' functions in mitosis. Despite having proteins in common, there is insufficient evidence for a specific connection between these two processes. Instead, these phenomena demonstrate the adaptability of the membrane trafficking machinery that allows its repurposing for different cellular functions.
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Acknowledgements
The author thanks L. Wood for useful comments and his colleagues in Liverpool and at Warwick Medical School for interesting discussions on moonlighting functions. He is supported by a Senior Cancer Research Fellowship from Cancer Research UK (C25425/A15182) and a project grant from the UK Biotechnology and Biological Sciences Research Council (BBSRC) (BB/H015582/1).
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Royle, S. Protein adaptation: mitotic functions for membrane trafficking proteins. Nat Rev Mol Cell Biol 14, 592–599 (2013). https://doi.org/10.1038/nrm3641
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