A population-based retrospective cohort study of data from more than 40,000 UK patients has determined that knee or hip replacements are more likely to last longer in patients who take bisphosphonates than those who do not (implant survival hazard ratio 0.54 [95% CI 0.29–0.99]; P = 0.047). Patients who used bisphosphonates had a lower rate of prosthetic revision 5 years after primary placement of the prosthesis than nonusers.
ORIGINAL RESEARCH PAPER
Prieto-Alhambra, D. et al. Association between bisphosphonate use and implant survival after primary total arthroplasty of the keen or hip: population based retrospective cohort study. BMJ doi:10.1136/bmj.d7222
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Bisphosphonates recommended after arthroplasty. Nat Rev Rheumatol 8, 62 (2012). https://doi.org/10.1038/nrrheum.2011.214
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DOI: https://doi.org/10.1038/nrrheum.2011.214