A matrix has been developed to predict which patients with early rheumatoid arthritis will have rapid radiographic progression (RRP) despite treatment with DMARDs. On the basis of data from 370 patients, 11.1% of whom had RRP (defined by change in van der Heijde-modified Sharp score) after 1 year, key baseline predictors of RRP are swollen joint count, C-reactive protein level, and the presence of anticitrullinated protein antibodies and radiographic erosions.
ORIGINAL RESEARCH PAPER
Fautrel B. et al. Matrix to predict rapid radiographic progression of early rheumatoid arthritis patients from the community treated with methotrexate or leflunomide: results from the ESPOIR cohort. Arthritis Res. Ther. 14, R249 (2012)
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Matrix predicts progression in patients with early RA. Nat Rev Rheumatol 9, 2 (2013). https://doi.org/10.1038/nrrheum.2012.212
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DOI: https://doi.org/10.1038/nrrheum.2012.212