Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

Paediatric rheumatology in 2017

Child-centred research is the key to progress

Nature Reviews Rheumatology volume 14, pages 69–70 (2018)Cite this article

Subjects

The rarity, severity and complexity of paediatric rheumatic diseases make progress in treating these diseases a challenge. In 2017, a new series of recommendations for treatment, studies that unravel the complexity of juvenile idiopathic arthritis and clinical trials that tackle sight-threatening uveitis have helped to improve paediatric care.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Keeping the child at the centre of paediatric research.

References

  1. Kuemmerle-Deschner, J. B. et al. Recommendations for collaborative paediatric research including biobanking in Europe: a single hub and access point for paediatric rheumatology in Europe (SHARE) initiative. Ann. Rheum. Dis. 10.1136/annrheumdis-2017-211904 (2017).

  2. Ombrello, M. J. et al. Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications. Ann. Rheum. Dis. 76, 906–913 (2017).

    Article  CAS  Google Scholar 

  3. Ramanan, A. V. et al. Adalimumab plus methotrexate for uveitis in juvenile idiopathic arthritis. N. Engl. J. Med. 376, 1637–1646 (2017).

    Article  CAS  Google Scholar 

  4. Enders, F. B. et al. Consensus-based recommendations for the management of juvenile dermatomyositis. Ann. Rheum. Dis. 76, 329–340 (2017).

    Article  Google Scholar 

  5. Groot, N. et al. European evidence-based recommendations for diagnosis and treatment of paediatric antiphospholipid syndrome: the SHARE initiative. Ann. Rheum. Dis. 76, 1637–1641 (2017).

    Article  CAS  Google Scholar 

  6. Groot, N. et al. European evidence-based recommendations for diagnosis and treatment of childhood-onset systemic lupus erythematosus: the SHARE initiative. Ann. Rheum. Dis. 76, 1788–1796 (2017).

    Article  CAS  Google Scholar 

  7. Groot, N. et al. European evidence-based recommendations for the diagnosis and treatment of childhood-onset lupus nephritis: the SHARE initiative. Ann. Rheum. Dis. 76, 1965–1973 (2017).

    Article  CAS  Google Scholar 

  8. Hinks, A. et al. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat. Genet. 45, 664–669 (2013).

    Article  CAS  Google Scholar 

  9. European Medicines Agency. EU regulatory workshop — ophthalmology — summary and report. Clinical development, scientific advice and paediatric investigation plans. EMA http://www.ema.europa.eu/docs/en_GB/document_library/Report/2012/09/WC500131815.pdf (2012).

  10. Woodcock, J. & LaVange, L. M. Master protocols to study multiple therapies, multiple diseases, or both. N. Engl. J. Med. 377, 62–70 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust and at the Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Institute in the Park, Alder Hey Children's NHS Foundation Trust, East Prescott Road, Liverpool, L14 5AB, UK

    Michael W. Beresford

  2. Bristol Royal Hospital for Children and at the Bristol Medical School, University of Bristol, Upper Maudlin Street, Bristol, BS2 8BJ, UK

    Athimalaipet V. Ramanan

Authors
  1. Michael W. Beresford
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Athimalaipet V. Ramanan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael W. Beresford.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Beresford, M., Ramanan, A. Child-centred research is the key to progress. Nat Rev Rheumatol 14, 69–70 (2018). https://doi.org/10.1038/nrrheum.2017.214

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2017.214

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing