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Less invasive surfactant administration methods: Who, what and how

Journal of Perinatology volume 44, pages 472–477 (2024)Cite this article

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Abstract

Surfactant administration via an endotracheal tube (ETT) has been the standard of care for infants with respiratory distress syndrome for decades. As non-invasive ventilation has become commonplace in the NICU, methods for administering surfactant without use of an ETT have been developed. These methods include thin catheter techniques (LISA, MIST), aerosolization/ nebulization, and surfactant administration through laryngeal (LMA) or supraglottic airways (SALSA). This review will describe these methods and discuss considerations and implementation into clinical practice.

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Fig. 1: MIST/LISA technique. Used with permission.
Fig. 2: Aerosol technique.
Fig. 3: SALSA technique.

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  1. These authors contributed equally: S. O. Guthrie, K. D. Roberts.

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  1. Department of Pediatrics, Division of Neonatology, Vanderbilt University School of Medicine, Nashville, TN, USA

    S. O. Guthrie

  2. Department of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA

    K. D. Roberts

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SG and KR contributed equally to the design, drafting, revising, and final approval of the manuscript.

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Guthrie, S.O., Roberts, K.D. Less invasive surfactant administration methods: Who, what and how. J Perinatol 44, 472–477 (2024). https://doi.org/10.1038/s41372-023-01778-2

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