The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.
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P.S.A. has received research funding from ATARA Biotherapeutics and Acea Biosciences; has served on the scientific advisory boards of, or as a consultant for, ATARA Biotherapeutics, Bayer, Carisma Therapeutics, Imugene, ImmpactBio and Takeda Therapeutics; has pending patent applications on T-cell therapies; and has patents, royalties and intellectual property on mesothelin-targeted CARs and other T-cell therapies and on methods for the detection of cancer cells using viruses. L.C. declares no competing interests.
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Cherkassky, L., Adusumilli, P.S. Arming T cells to infiltrate pancreatic tumours. Nat Biomed Eng 5, 1243–1245 (2021). https://doi.org/10.1038/s41551-021-00821-x
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DOI: https://doi.org/10.1038/s41551-021-00821-x