Durable responses with first-line platinum-based chemotherapy for advanced-stage urothelial carcinoma are rare, and patient outcomes are poor. Recently, CheckMate 901 became the first phase III trial to establish a significant overall survival benefit from a combined chemoimmunotherapy approach in this disease setting. Herein, we discuss key findings from CheckMate 901 and their implications in the context of a rapidly evolving treatment landscape.
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N.A. declares grants (to her institution) from AstraZeneca and EMD Serono, and consulting and/or advisory roles for AstraZeneca, Bayer, Bristol Myers Squibb, EMD Serono, Gilead, Janssen, Merck, Pfizer and Seagen. S.S.S. declares research funding (to her institution) from EMD Serono, Janssen and Seagen, and consulting and/or advisory roles for Astellas, AstraZeneca, Bayer, Bicycle Therapeutics, Bristol Myers Squibb, Eisai, EMD Serono, Gilead, Ipsen, Janssen, Merck, Pfizer and Seagen.
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Alimohamed, N., Sridhar, S.S. Combination strategies for advanced-stage urothelial carcinoma: a paradigm shift. Nat Rev Clin Oncol 21, 255–256 (2024). https://doi.org/10.1038/s41571-024-00861-7
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DOI: https://doi.org/10.1038/s41571-024-00861-7