Remission of type 2 diabetes mellitus is highly desirable and potentially reduces risks of complications. Improving the probability of remission requires early detection and substantial weight loss during a 6-year therapeutic window when β-cells remain functional.
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References
Fang, M., Wang, D., Coresh, J. & Selvin, E. Trends in diabetes treatment and control in U.S. adults, 1999–2018. N. Engl. J. Med. 384, 2219–2228 (2021).
Wang, L. et al. Trends in prevalence of diabetes and control of risk factors in diabetes among US adults, 1999–2018. J. Am. Med. Assoc. 326, 1–13 (2021).
Gregg, E. W., Hora, I. & Benoit, S. R. Resurgence in diabetes-related complications. J. Am. Med. Assoc. 321, 1867–1868 (2019).
Lean, M. E. J. et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol. 7, 344–355 (2019).
Taheri, S. et al. Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. Lancet Diabetes Endocrinol. 8, 477–489 (2020).
Gregg, E. W. et al. Look AHEAD Research Group. Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 4, 913–921 (2016).
Sjöström, L. et al. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. J. Am. Med. Assoc. 311, 2297–2304 (2014).
Fultang, J., Chinaka, U., Rankin, J., Bakhshi, A. & Ali, A. Preoperative bariatric surgery predictors of type 2 diabetes remission. J. Obes. Metab. Syndr. 30, 104–114 (2021).
Lind, M., Imberg, H., Coleman, R. L., Nerman, O. & Holman, R. R. Historical HbA1c values may explain the type 2 diabetes legacy effect: UKPDS 88. Diabetes Care 44, 2231–2237 (2021).
Riddle, M. C. et al. Consensus Report: definition and interpretation of remission in Type 2 diabetes. Diabetes Care 44, 2438–2444 (2021).
Acknowledgements
Professor José Luiz Medina passed away recently after a prolonged illness. He was Professor Emeritus at the Faculty of Medicine of the University of Porto. His scholarship, influence, commitment to young trainees in endocrinology, humanism and contribution to public health were renowned throughout Portugal. Professor Medina touched many lives and his memory will continue to inspire future generations.
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Bergman, M., Buysschaert, M., Medina, J.L. et al. Remission of T2DM requires early diagnosis and substantial weight reduction. Nat Rev Endocrinol 18, 329–330 (2022). https://doi.org/10.1038/s41574-022-00670-x
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DOI: https://doi.org/10.1038/s41574-022-00670-x