Two studies have confirmed previous observations that an inverse relationship exists between chronological age and focal white-matter inflammatory activity in individuals with multiple sclerosis, which could underlie the relative ineffectiveness of traditional disease-modifying therapies in older individuals.
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Segal, B.M. Inverse association between age and inflammatory disease activity in multiple sclerosis. Nat Rev Neurol 19, 577–578 (2023). https://doi.org/10.1038/s41582-023-00844-9
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DOI: https://doi.org/10.1038/s41582-023-00844-9