New guidelines for designing controlled clinical trials for idiopathic intracranial hypertension (IIH) have been published. The design of such trials remains a challenge, as the heterogeneity of IIH necessitates different outcome measures for specific clinical presentations.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mollan, S. P. et al. Guidelines of the International Headache Society for controlled clinical trials in idiopathic intracranial hypertension. Cephalalgia https://doi.org/10.1177/03331024231197118 (2023).
Mollan, S. P., Aguiar, M., Evison, F., Frew, E. & Sinclair, A. J. The expanding burden of idiopathic intracranial hypertension. Eye (Lond.) 33, 478–485 (2019).
Friedman, D. I., Liu, G. T. & Digre, K. B. Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children. Neurology 81, 1159–1165 (2013).
Biousse, V. & Newman, N. J. The expanding spectrum of idiopathic intracranial hypertension. Eye (Lond.) 37, 2361–2364 (2023).
Mollan, S. P. et al. Idiopathic intracranial hypertension: consensus guidelines on management. J. Neurol. Neurosurg. Psychiatry 89, 1088–1100 (2018).
Mollan, S. P., Grech, O. & Sinclair, A. J. Headache attributed to idiopathic intracranial hypertension and persistent post-idiopathic intracranial hypertension headache: a narrative review. Headache 61, 808–816 (2021).
Wall, M. et al. Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. J. Am. Med. Assoc. 311, 1641–1651 (2014).
Surgical Idiopathic Intracranial Hypertension Treatment Trial (SIGHT). ClinicalTrial.gov https://clinicaltrials.gov/ct2/show/NCT03501966 (2023).
Efficacy and Safety of Presendin in IIH (IIH EVOLVE). ClinicalTrial.gov https://clinicaltrials.gov/study/NCT05347147 (2023).
Dinkin, M. J. & Patsalides, A. Idiopathic intracranial venous hypertension: toward a better understanding of venous stenosis and the role of stenting in idiopathic intracranial hypertension. J Neuro-ophthalmol. https://doi.org/10.1097/WNO.0000000000001898 (2023).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Biousse, V., Newman, N.J. Clinical trials for idiopathic intracranial hypertension: what are we treating?. Nat Rev Neurol 20, 3–4 (2024). https://doi.org/10.1038/s41582-023-00892-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41582-023-00892-1
