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Alzheimer disease

Could microbiota transfer between cohabitants influence Alzheimer disease risk?

Nature Reviews Neurology volume 19, pages 713–714 (2023)Cite this article

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The underlying cause of sporadic Alzheimer disease (AD) remains enigmatic, but an increased risk among spouses of people with AD has led to speculation of transmissibility. A mouse study now suggests that the transfer of microbiota could underlie this potential transmissibility, but the findings leave many questions unanswered.

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References

  1. Norton, M. C. et al. Greater risk of dementia when spouse has dementia? The Cache County study. J. Am. Geriatr. Soc. 58, 895–900 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Challis, C. et al. Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nat. Neurosci. 23, 327–336 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Zhang, Y. et al. Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients. Mol. Psychiatry https://doi.org/10.1038/s41380-023-02216-7 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Kim, N. et al. Transplantation of gut microbiota derived from Alzheimer’s disease mouse model impairs memory function and neurogenesis in C57BL/6 mice. Brain Behav. Immun. 98, 357–365 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Sha, H. et al. Blocking coprophagy increases the levels of inflammation and depression in healthy mice as well as mice receiving fecal microbiota transplantation from disease model mice donors. APMIS 131, 351–368 (2023).

    Article  CAS  PubMed  Google Scholar 

  6. Sun, J. et al. Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice. Transl. Psychiatry 9, 189 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  7. dos Santos Guilherme, M. et al. Impact of acute and chronic amyloid-β peptide exposure on gut microbial commensals in the mouse. Front. Microbiol. 11, 1008 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Semar, S. et al. Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression. J. Alzheimers Dis. 36, 7–20 (2013).

    Article  CAS  PubMed  Google Scholar 

  9. Wu, S. et al. Excretion of amyloid-β in the gastrointestinal tract and regulation by the gut microbiota. J. Alzheimers Dis. 90, 1153–1162 (2022).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany

    Kristina Endres

  2. Working Group Enteric Nervous System, University of Applied Sciences, Kaiserslautern, Germany

    Karl-Herbert Schäfer

Authors
  1. Kristina Endres
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  2. Karl-Herbert Schäfer
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Corresponding author

Correspondence to Kristina Endres.

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The authors declare no competing interests.

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Endres, K., Schäfer, KH. Could microbiota transfer between cohabitants influence Alzheimer disease risk?. Nat Rev Neurol 19, 713–714 (2023). https://doi.org/10.1038/s41582-023-00894-z

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