The Human Cell Atlas (HCA) project aims to map tissues and organs during development, maturation and pathology at single cell resolution. The musculoskeletal HCA network is a community for fostering collaboration and shared expertise to help develop the therapeutic approaches needed to address the high global burden of musculoskeletal disorders.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries
European Journal of Human Genetics Open Access 02 April 2024
-
Fighting age-related orthopedic diseases: focusing on ferroptosis
Bone Research Open Access 01 March 2023
-
Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier
European Journal of Medical Research Open Access 20 February 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
The HCA Consortium. The Human Cell Atlas. White Paper https://www.humancellatlas.org/wp-content/uploads/2019/11/HCA_WhitePaper_18Oct2017-copyright.pdf (2017).
Cieza, A. et al. Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 2006–2017 (2021).
McMahon, S. B. et al. The burden of musculoskeletal pain and the role of topical non-steroidal anti-inflammatory drugs (NSAIDs) in its treatment. Ten underpinning statements from a global pain faculty. Curr. Med. Res. Opin. 37, 287–292 (2020).
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392, 1789–1858 (2018).
Lee, R. C. et al. Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models. Am. J. Clin. Nutr. 72, 796–803 (2000).
Vieira Braga, F. A. et al. A cellular census of human lungs identifies novel cell states in health and in asthma. Nat. Med. 25, 1153–1163 (2019).
Aizarani, N. et al. A human liver cell atlas reveals heterogeneity and epithelial progenitors. Nature 572, 199–204 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Related links
HCA Data Coordination Platform: https://data.humancellatlas.org/contribute
Human Cell Atlas: https://www.humancellatlas.org/
Musculoskeletal HCA network: https://www.humancellatlas.org/areas-of-impact/
Rights and permissions
About this article
Cite this article
Baldwin, M.J., Cribbs, A.P., Guilak, F. et al. Mapping the musculoskeletal system one cell at a time. Nat Rev Rheumatol 17, 247–248 (2021). https://doi.org/10.1038/s41584-021-00600-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41584-021-00600-7
This article is cited by
-
Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries
European Journal of Human Genetics (2024)
-
Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier
European Journal of Medical Research (2023)
-
Fighting age-related orthopedic diseases: focusing on ferroptosis
Bone Research (2023)
-
The Musculoskeletal Knowledge Portal: improving access to multi-omics data
Nature Reviews Rheumatology (2022)
-
Understanding the Transcriptomic Landscape to Drive New Innovations in Musculoskeletal Regenerative Medicine
Current Osteoporosis Reports (2022)