New data confirm that APOE4 homozygosity is a major genetic cause of Alzheimer’s disease, warranting the development of specialized research strategies, treatment approaches and clinical trials.
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Acknowledgements
This work is partially supported by grants P01AG073082 and RF1AG076647 to Y.H. from the National Institutes of Health. The authors thank R. Mahley, L. Mucke and J. Blumenfeld for their feedback on the article.
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Y.H. is a co-founder and scientific advisory board member of GABAeron, Inc. The other authors declare no competing interests.
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Xu, Q., Liang, Z. & Huang, Y. APOE4 homozygosity is a new genetic form of Alzheimer’s disease. Nat Med (2024). https://doi.org/10.1038/s41591-024-02923-w
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DOI: https://doi.org/10.1038/s41591-024-02923-w