Ketamine has transformed the treatment of depression by providing rapid relief from depressive symptoms, but the mechanisms mediating its long-term effects are unclear. Kim et al. show that MeCP2 signaling in the hippocampus is critical for supporting sustained antidepressant effects.
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References
Berman, R. M. et al. Biol. Psychiatry 47, 351–354 (2000).
Zarate, C. A. Jr et al. Arch. Gen. Psychiatry 63, 856–864 (2006).
Autry, A. E. et al. Nature 475, 91–95 (2011).
Li, N. et al. 329, 959–964 (2010).
Kim J.-W. et al. Nat. Neurosci. https://doi.org/s41593-021-00868-8 (2021).
Voleti, B. et al. Biol. Psychiatry 74, 742–749 (2013).
Furey, M. L. & Drevets, W. C. Arch. Gen. Psychiatry 63, 1121–1129 (2006).
Moda-Sava, R. N. et al. Science 364, eaat8078 (2019).
Yang, Y. et al. Nature 554, 317–322 (2018).
Wu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P. & Kozorovitskiy, Y. Biol. Psychiatry 89, 1096–1105 (2021).
Carreno, F. R. et al. Mol. Psychiatry 21, 1298–1308 (2016).
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Johnson, S., Liston, C. MeCP2 for sustained antidepressant effects. Nat Neurosci 24, 1047–1048 (2021). https://doi.org/10.1038/s41593-021-00881-x
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DOI: https://doi.org/10.1038/s41593-021-00881-x
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