Microglial synapse engulfment precedes brain amyloid plaque formation and probably contributes to early cognitive decline in Alzheimer’s disease. The mechanisms that regulate microglia-mediated synapse engulfment are unclear. De Schepper et al. show that perivascular SPP1 induces microglia-mediated synapse engulfment, highlighting a neuroimmune interaction that contributes to synapse loss in amyloid pathology.
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O’Brien, C.A., Bennett, F.C. Perivascular signals drive microglial appetite. Nat Neurosci 26, 369–370 (2023). https://doi.org/10.1038/s41593-023-01256-0
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DOI: https://doi.org/10.1038/s41593-023-01256-0