Loss-of-function variants of TREM2 increase risk for Alzheimer’s disease. A new study presents a therapeutic candidate — ATV:TREM2, a TREM2-activating antibody engineered with a transferrin receptor binding site to facilitate blood-to-brain transport. Treatment of a mouse model of Alzheimer’s disease with ATV:TREM2 improved energy metabolism and microglial function.
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Acknowledgements
N.Z. is supported by NIH/NIA grant R01AG066395.
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G.B. is an employee of SciNeuro Pharmaceuticals.
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Zhao, N., Bu, G. A TREM2 antibody energizes microglia. Nat Neurosci 26, 366–368 (2023). https://doi.org/10.1038/s41593-023-01265-z
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DOI: https://doi.org/10.1038/s41593-023-01265-z
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