Bone resorption by osteoclasts requires tight control, as overactivation reduces bone mass and strength. Stegen et al. demonstrate that α-ketoglutarate produced during serine synthesis promotes osteoclast development via metabolic–epigenetic coupling and could be a therapeutic target.
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Acknowledgements
Work in the laboratory of R.C.R. is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK099134) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR077533) of the National Institutes of Health as well as the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development (BX003724).
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Riddle, R.C., Choquette, G.M. Serine synthesis promotes bone degradation. Nat Metab 6, 8–9 (2024). https://doi.org/10.1038/s42255-023-00949-x
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DOI: https://doi.org/10.1038/s42255-023-00949-x