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Immunometabolism

Tonic-ing emissions and compatibility to turbocharge CAR-T

Nature Metabolism (2024)Cite this article

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Optimization of energy and carbon–nitrogen allocation maximizes the proliferation and functionality of chimeric antigen receptor (CAR)-T cells. Lakhani et al. report that tonic signalling elements (scFvs) affect CAR-T cell metabolic fitness in an antigen-independent manner. A modest carbon–nitrogen emission (overflow) and resilient metabolic phenotype (compatibility) are associated with effective CAR-T cell therapy.

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Fig. 1: Tuning tonic signalling and metabolic fitness to enhance CAR-T cell performance.

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Author notes

  1. These authors contributed equally: Haopeng Wang, Yuwei Huang.

Authors and Affiliations

  1. School of Life Science and Technology, ShanghaiTech University, Shanghai, China

    Haopeng Wang & Yuwei Huang

  2. State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China

    Haopeng Wang

  3. Shanghai Clinical Research and Trial Center, Shanghai, China

    Haopeng Wang

  4. Lingang Laboratory, Shanghai, China

    Yuwei Huang

  5. Center for Childhood Cancer Research, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, Ohio State University, Columbus, OH, USA

    Ruoning Wang

Authors
  1. Haopeng Wang
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  2. Yuwei Huang
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  3. Ruoning Wang
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Correspondence to Haopeng Wang or Ruoning Wang.

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Wang, H., Huang, Y. & Wang, R. Tonic-ing emissions and compatibility to turbocharge CAR-T. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01022-x

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