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Metabolic disease

Macrophage vesicles in antidiabetic drug action

Nature Metabolism (2024)Cite this article

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Thiazolidinediones (TZDs) are potent insulin-sensitizing drugs, but their use is accompanied by adverse side-effects. Rohm et al. now report that TZD-stimulated macrophages release miR-690-containing vesicles that improve insulin sensitization and bypass unwanted side-effects.

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Fig. 1: TZDs induce the production of insulin-sensitizing extracellular vesicles by macrophages.

References

  1. Blüher, M. Nat. Rev. Endocrinol. 15, 288–298 (2019).

    Article  PubMed  Google Scholar 

  2. Johnson, A. M. & Olefsky, J. M. Cell 152, 673–684 (2013).

    Article  CAS  PubMed  Google Scholar 

  3. Freeman, D. W. et al. Diabetes 67, 2377–2388 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kranendonk, M. E. et al. Obesity 22, 1296–1308 (2014).

    Article  CAS  PubMed  Google Scholar 

  5. Kulaj, K. et al. Nat. Commun. 14, 709 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Blandin, A. et al. Cell Rep. 42, 112866 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Ying, W. et al. Cell 171, 372–384.e12 (2017).

    Article  CAS  PubMed  Google Scholar 

  8. Hernandez-Quiles, M., Broekema, M. F. & Kalkhoven, E. Front. Endocrinol. 12, 624112 (2021).

    Article  Google Scholar 

  9. Stienstra, R. et al. J. Biol. Chem. 283, 22620–22627 (2008).

    Article  CAS  PubMed  Google Scholar 

  10. Cariou, B., Charbonnel, B. & Staels, B. Trends Endocrinol. Metab. 23, 205–215 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. Ahmadian, M. et al. Nat. Med. 19, 557–566 (2013).

    Article  CAS  PubMed  Google Scholar 

  12. Rohm, T. V. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-01023-w (2024).

    Article  Google Scholar 

  13. Ying, W. et al. Cell Metab. 33, 781–790.e5 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Gao, H. et al. Cell Metab. 34, 978–990.e4 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Li, Z., Wang, Y., Li, S. & Li, Y. Front. Endocrinol. 12, 680328 (2021).

    Article  Google Scholar 

Download references

Acknowledgements

We acknowledge funding from ZonMw and the Dutch Diabetes Research Foundation to R.S. and from the Netherlands Organisation for Health Research and Development (ZonMw) programme for translational research, and Diabetes Fonds (project number 95105007) to E.K.

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Authors and Affiliations

  1. Department of Internal Medicine, Radboudumc, Nijmegen, the Netherlands

    Rinke Stienstra

  2. Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands

    Rinke Stienstra

  3. Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands

    Eric Kalkhoven

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  1. Rinke Stienstra
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  2. Eric Kalkhoven
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Correspondence to Eric Kalkhoven.

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Stienstra, R., Kalkhoven, E. Macrophage vesicles in antidiabetic drug action. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01030-x

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