Pancreatic cancer liver metastases show high levels of immunosuppressive macrophages, which promote tumor growth. We found that blocking the efferocytosis pathway during early-stage metastasis in a mouse model inhibited the development of immunosuppressive activity in monocyte-derived macrophages, which restored T cell activation and reduced the metastatic tumor burden.
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References
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This is a summary of: Astuti, Y. et al. Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nat. Cancer https://doi.org/10.1038/s43018-024-00731-2 (2024).
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Clearance of dead cells by efferocytosis promotes liver metastasis in pancreatic cancer. Nat Cancer 5, 699–700 (2024). https://doi.org/10.1038/s43018-024-00732-1
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DOI: https://doi.org/10.1038/s43018-024-00732-1