Web focus: Quality Control

See also: DNA quality control
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- Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesisFREE
  Xiaolan Guo, Yibin Deng, Yahong Lin, Wilfredo Cosme-Blanco, Suzanne Chan, Hua He, Guohua Yuan, Eric J Brown and Sandy Chang
  The EMBO Journal (2007), 26, - 4709–4719 | doi:10.1038/sj.emboj.7601893
  - Abstract - Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
  - Full text
  - PDF (519 KB) - Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
  - Supplementary information
- TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivoFREE
  Sachin Katyal, Sherif F El-Khamisy, Helen R Russell, Yang Li, Limei Ju, Keith W Caldecott and Peter J McKinnon
  The EMBO Journal (2007), 26, - 4720–4731 | doi:10.1038/sj.emboj.7601869
  - Abstract - TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective : in vivo
  - Full text
  - PDF (589 KB) - TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective : in vivo
- Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPAFREE
  Oleg V Tsodikov, Dmitri Ivanov, Barbara Orelli, Lidija Staresincic, Ilana Shoshani, Robert Oberman, Orlando D Schärer, Gerhard Wagner and Tom Ellenberger
  The EMBO Journal (2007), 26, - 4768–4776 | doi:10.1038/sj.emboj.7601894
  - Abstract - Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA
  - Full text
  - PDF (304 KB) - Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA
  - Supplementary information
- Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forksFREE
  François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot and Patrice Polard
  The EMBO Journal (2007), 26, - 4239–4251 | doi:10.1038/sj.emboj.7601848
  - Abstract - Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks
  - Full text
  - PDF (623 KB) - Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks
  - Supplementary information
- SUMO-targeted ubiquitin ligases in genome stability FREE
  John Prudden, Stephanie Pebernard, Grazia Raffa, Daniela A Slavin, J Jefferson P Perry, John A Tainer, Clare H McGowan and Michael N Boddy
  The EMBO Journal (2007), 26, - 4089–4101 | doi:10.1038/sj.emboj.7601838
  - Abstract - SUMO-targeted ubiquitin ligases in genome stability
  - Full text
  - PDF (686 KB) - SUMO-targeted ubiquitin ligases in genome stability
  - Supplementary information
- Replication blocking lesions present a unique substrate for homologous recombinationFREE
  Jordan D Ward, Louise J Barber, Mark IR Petalcorin, Judith Yanowitz and Simon J Boulton
  The EMBO Journal (2007), 26, - 3384–3396 | doi:10.1038/sj.emboj.7601766
  - Abstract - Replication blocking lesions present a unique substrate for homologous recombination
  - Full text
  - PDF (452 KB) - Replication blocking lesions present a unique substrate for homologous recombination
  - Supplementary information
- BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridgesFREE
  Kok-Lung Chan, Phillip S North and Ian D Hickson
  The EMBO Journal (2007), 26, - 3397–3409 | doi:10.1038/sj.emboj.7601777
  - Abstract - BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
  - Full text
  - PDF (495 KB) - BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
  - Supplementary information
- The FANCJ/MutL interaction is required for correction of the cross-link response in FA-J cellsFREE
  Min Peng, Rachel Litman, Jenny Xie, Sudha Sharma, Robert M Brosh Jr and Sharon B Cantor
  The EMBO Journal (2007), 26, - 3238–3249 | doi:10.1038/sj.emboj.7601754
  - Abstract - The FANCJ/MutL[alpha] interaction is required for correction of the cross-link response in FA-J cells
  - Full text
  - PDF (327 KB) - The FANCJ/MutL[alpha] interaction is required for correction of the cross-link response in FA-J cells
  - Supplementary information
- ATMIN defines an NBS1-independent pathway of ATM signallingFREE
  Nnennaya Kanu and Axel Behrens
  The EMBO Journal (2007), 26, - 2933–2941 | doi:10.1038/sj.emboj.7601733
  - Abstract - ATMIN defines an NBS1-independent pathway of ATM signalling
  - Full text
  - PDF (319 KB) - ATMIN defines an NBS1-independent pathway of ATM signalling
  - Supplementary information
- BRCA2 is required for neurogenesis and suppression of medulloblastoma FREE
  Pierre-Olivier Frappart, Youngsoo Lee, Jayne Lamont and Peter J McKinnon
  The EMBO Journal (2007), 26, - 2732–2742 | doi:10.1038/sj.emboj.7601703
  - Abstract - BRCA2 is required for neurogenesis and suppression of medulloblastoma
  - Full text
  - PDF (546 KB) - BRCA2 is required for neurogenesis and suppression of medulloblastoma
  - Supplementary information
- Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeresFREE
  Andreas Meier, Heike Fiegler, Purificacion Muñoz, Peter Ellis, Diane Rigler, Cordelia Langford, Maria A Blasco, Nigel Carter and Stephen P Jackson
  The EMBO Journal (2007), 26, - 2707–2718 | doi:10.1038/sj.emboj.7601719
  - Abstract - Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres
  - Full text
  - PDF (736 KB) - Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres
  - Supplementary information
- FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathwayFREE
  Chen Ling, Masamichi Ishiai, Abdullah Mahmood Ali, Annette L Medhurst, Kornelia Neveling, Reinhard Kalb, Zhijiang Yan, Yutong Xue, Anneke B Oostra, Arleen D Auerbach, Maureen E Hoatlin, Detlev Schindler, Hans Joenje, Johan P de Winter, Minoru Takata, Amom Ruhikanta Meetei and Weidong Wang
  The EMBO Journal (2007), 26, - 2104–2114 | doi:10.1038/sj.emboj.7601666
  - Abstract - FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway
  - Full text
  - PDF (378 KB) - FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway
  - Supplementary information
- Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stabilityFREE
  Massimo Bogliolo, Alex Lyakhovich, Elsa Callén, Maria Castellà, Enrico Cappelli, María J Ramírez, Amadeu Creus, Ricard Marcos, Reinhard Kalb, Kornelia Neveling, Detlev Schindler and Jordi Surrallés
  The EMBO Journal (2007), 26, - 1340–1351 | doi:10.1038/sj.emboj.7601574
  - Abstract - Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability
  - Full text
  - PDF (345 KB) - Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability
- XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gapsFREE
  Jiafeng Gu, Haihui Lu, Brigette Tippin, Noriko Shimazaki, Myron F Goodman and Michael R Lieber
  The EMBO Journal (2007), 26, - 1010–1023 | doi:10.1038/sj.emboj.7601559
  - Abstract - XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
  - Full text
  - PDF (320 KB) - XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
  - Supplementary information
- Impaired DNA damage checkpoint response in MIF-deficient miceFREE
  Alice Nemajerova, Patricio Mena, Gunter Fingerle-Rowson, Ute M Moll and Oleksi Petrenko
  The EMBO Journal (2007), 26, - 987–997 | doi:10.1038/sj.emboj.7601564
  - Abstract - Impaired DNA damage checkpoint response in MIF-deficient mice
  - Full text
  - PDF (538 KB) - Impaired DNA damage checkpoint response in MIF-deficient mice
  - Supplementary information
- RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesisFREE
  Shingo Fujii, Asako Isogawa and Robert P Fuchs
  The EMBO Journal (2006), 25, - 5754–5763 | doi:10.1038/sj.emboj.7601474
  - Abstract - RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis
  - Full text
  - PDF (528 KB) - RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis
  - Supplementary information
- ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stallingFREE
  Thomas Stiff, Sarah A Walker, Karen Cerosaletti, Aaron A Goodarzi, Eva Petermann, Pat Concannon, Mark O'Driscoll and Penny A Jeggo
  The EMBO Journal (2006), 25, - 5775–5782 | doi:10.1038/sj.emboj.7601446
  - Abstract - ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
  - Full text
  - PDF (343 KB) - ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
  - Supplementary information
- Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaksFREE
  Yun-Gui Yang, Amal Saidi, Pierre-Olivier Frappart, Wookee Min, Christelle Barrucand, Valérie Dumon-Jones, Jocelyne Michelon, Zdenko Herceg and Zhao-Qi Wang
  The EMBO Journal (2006), 25, - 5527–5538 | doi:10.1038/sj.emboj.7601411
  - Abstract - Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks
  - Full text
  - PDF (320 KB) - Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks
  - Supplementary information
- POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationFREE
  Hua He, Asha S Multani, Wilfredo Cosme-Blanco, Hidetoshi Tahara, Jin Ma, Sen Pathak, Yibin Deng and Sandy Chang
  The EMBO Journal (2006), 25, - 5180–5190 | doi:10.1038/sj.emboj.7601294
  - Abstract - POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination
  - Full text
  - PDF - POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination
  - Supplementary information
- The structure-specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaksFREE
  Katsuhiro Hanada, Magda Budzowska, Mauro Modesti, Alex Maas, Claire Wyman, Jeroen Essers and Roland Kanaar
  The EMBO Journal (2006), 25, - 4921–4932 | doi:10.1038/sj.emboj.7601344
  - Abstract - The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks
  - Full text
  - PDF (626 KB) - The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks
  - Supplementary information
- New functions of XPC in the protection of human skin cells from oxidative damageFREE
  Mariarosaria D'Errico, Eleonora Parlanti, Massimo Teson, Bruno M Bernardes de Jesus, Paolo Degan, Angelo Calcagnile, Pawel Jaruga, Magnar Bjørås, Marco Crescenzi, Antonia M Pedrini, Jean-Marc Egly, Giovanna Zambruno, Miria Stefanini, Miral Dizdaroglu and Eugenia Dogliotti
  The EMBO Journal (2006), 25, - 4305–4315 | doi:10.1038/sj.emboj.7601277
  - Abstract - New functions of XPC in the protection of human skin cells from oxidative damage
  - Full text
  - PDF (248 KB) - New functions of XPC in the protection of human skin cells from oxidative damage
- Mechanism of RecA-mediated homologous recombination revisited by single molecule nanomanipulationFREE
  Renaud Fulconis, Judith Mine, Aurélien Bancaud, Marie Dutreix and Jean-Louis Viovy
  The EMBO Journal (2006), 25, - 4293–4304 | doi:10.1038/sj.emboj.7601260
  - Abstract - Mechanism of RecA-mediated homologous recombination revisited by single molecule nanomanipulation
  - Full text
  - PDF (318 KB) - Mechanism of RecA-mediated homologous recombination revisited by single molecule nanomanipulation
  - Supplementary information
- DNA-PK autophosphorylation facilitates Artemis endonuclease activityspan class="free">FREE
  Aaron A Goodarzi, Yaping Yu, Enriqueta Riballo, Pauline Douglas, Sarah A Walker, Ruiqiong Ye, Christine Härer, Caterina Marchetti, Nick Morrice, Penny A Jeggo and Susan P Lees-Miller
  The EMBO Journal (2006), 25, - 3880–3889 | doi:10.1038/sj.emboj.7601255
  - Abstract - DNA-PK autophosphorylation facilitates Artemis endonuclease activity
  - Full text
  - PDF (481 KB) - DNA-PK autophosphorylation facilitates Artemis endonuclease activity
  - Supplementary information
- Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaksFREE
  Patrick Ryan Potts, Matthew H Porteus and Hongtao Yu
  The EMBO Journal (2006), 25, - 3377–3388 | doi:10.1038/sj.emboj.7601218
  - Abstract - Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks
  - Full text
  - PDF (260 KB) - Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks
  - Supplementary information
- Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeFREE
  Antony W Oliver, Angela Paul, Katherine J Boxall, S Elaine Barrie, G Wynne Aherne, Michelle D Garrett, Sibylle Mittnacht and Laurence H Pearl
  The EMBO Journal (2006), 25, - 3179–3190 | doi:10.1038/sj.emboj.7601209
  - Abstract - Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
  - Full text
  - PDF (622 KB) - Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
- Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNAFREE
  Jeanette Ringvoll, Line M Nordstrand, Cathrine B Vågbø, Vivi Talstad, Karen Reite, Per Arne Aas, Knut H Lauritzen, Nina Beate Liabakk, Alexandra Bjørk, Richard William Doughty, Pål Ø Falnes, Hans E Krokan and Arne Klungland
  The EMBO Journal (2006), 25, - 2189–2198 | doi:10.1038/sj.emboj.7601109
  - Abstract - Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
  - Full text
  - PDF (296 KB) - Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
  - Supplementary information
- ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiencyFREE
  Liu Cao, Sangsoo Kim, Cuiying Xiao, Rui-Hong Wang, Xavier Coumoul, Xiaoyan Wang, Wen Mei Li, Xiao Ling Xu, Joseph A De Soto, Hiroyuki Takai, Sabine Mai, Stephen J Elledge, Noboru Motoyama and Chu-Xia Deng
  The EMBO Journal (2006), 25, - 2167–2177 | doi:10.1038/sj.emboj.7601115
  - Abstract - ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency
  - Full text
  - PDF (664 KB) - ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency
  - Supplementary information
- Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cellsFREE
  Helfrid Hochegger, Donniphat Dejsuphong, Toru Fukushima, Ciaran Morrison, Eiichiro Sonoda, Valérie Schreiber, Guang Yu Zhao, Alihossein Saberi, Mitsuko Masutani, Noritaka Adachi, Hideki Koyama, Gilbert de Murcia and Shunichi Takeda
  The EMBO Journal (2006), 25, - 1305–1314 | doi:10.1038/sj.emboj.7601015
  - Abstract - Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
  - Full text
  - PDF (236 KB) - Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
  - Supplementary information
- SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repairFREE
  Javier M Di Noia, Cristina Rada and Michael S Neuberger
  The EMBO Journal (2006), 25, - 585–595 | doi:10.1038/sj.emboj.7600939
  - Abstract - SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair
  - Full text
  - PDF (362 KB) - SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair
  - Supplementary information

Web focus: Quality Control

See also: DNA quality control

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesisFREE

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivoFREE

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPAFREE

Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forksFREE

SUMO-targeted ubiquitin ligases in genome stability FREE

Replication blocking lesions present a unique substrate for homologous recombinationFREE

BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridgesFREE

The FANCJ/MutL interaction is required for correction of the cross-link response in FA-J cellsFREE

ATMIN defines an NBS1-independent pathway of ATM signallingFREE

BRCA2 is required for neurogenesis and suppression of medulloblastoma FREE

Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeresFREE

FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathwayFREE

Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stabilityFREE

XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gapsFREE

Impaired DNA damage checkpoint response in MIF-deficient miceFREE

RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesisFREE

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stallingFREE

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaksFREE

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationFREE

The structure-specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaksFREE

New functions of XPC in the protection of human skin cells from oxidative damageFREE

Mechanism of RecA-mediated homologous recombination revisited by single molecule nanomanipulationFREE

DNA-PK autophosphorylation facilitates Artemis endonuclease activityspan class="free">FREE

Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaksFREE

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeFREE

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNAFREE

ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiencyFREE

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cellsFREE

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repairFREE

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