Table of Contents
Volume 25, Number 9
03 May 2006
pp 1795-2038
Single-molecule studies on myosin V reveal several new mechanisms the molecular motor may use to navigate in the heterogeneous intracellular environment. The experiments (see article on page 1795 of this issue) simultaneously examined nanometer-resolved translational movements and orientational changes of fluorescently-tagged motor proteins in vitro and established that every translational step is associated with tilting of the motor�s lever arm. Additional reorientations are detected when the motor is waiting between steps, suggesting that myosin V may �probe� its vicinity before executing the next working stroke. The results also show that the molecular motor can alter its course around actin, possibly to avoid obstacles. Taken together, the different mechanisms show myosin V to be a highly agile intracellular cargo transporter.
Articles
Top of pageAdaptability of myosin V studied by simultaneous detection of position and orientation FREE
The EMBO Journal (2006), 25, - 1795 - 1803, doi:10.1038/sj.emboj.7601060
- Abstract - Adaptability of myosin V studied by simultaneous detection of position and orientation
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- PDF (422 KB) - Adaptability of myosin V studied by simultaneous detection of position and orientation
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Published online: 06 April 2006
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TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion FREE
The EMBO Journal (2006), 25, - 1804 - 1815, doi:10.1038/sj.emboj.7601083
- Abstract - TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion
- Full text
- PDF (363 KB) - TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion
- Supplementary information
Published online: 06 April 2006
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Regulation of actin dynamics by annexin 2 FREE
The EMBO Journal (2006), 25, - 1816 - 1826, doi:10.1038/sj.emboj.7601078
- Abstract - Regulation of actin dynamics by annexin 2
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- PDF (497 KB) - Regulation of actin dynamics by annexin 2
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Published online: 06 April 2006
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The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment FREE
The EMBO Journal (2006), 25, - 1827 - 1835, doi:10.1038/sj.emboj.7601088
- Abstract - The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
- Full text
- PDF (446 KB) - The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
- Supplementary information
Published online: 13 April 2006
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The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64 FREE
The EMBO Journal (2006), 25, - 1836 - 1847, doi:10.1038/sj.emboj.7601091
- Abstract - The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64
- Full text
- PDF (665 KB) - The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64
- Supplementary information
Published online: 13 April 2006
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GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover FREE
The EMBO Journal (2006), 25, - 1848 - 1859, doi:10.1038/sj.emboj.7601092
- Abstract - GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover
- Full text
- PDF (754 KB) - GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover
- Supplementary information
Published online: 20 April 2006
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Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration FREE
The EMBO Journal (2006), 25, - 1860 - 1870, doi:10.1038/sj.emboj.7601082
- Abstract - Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration
- Full text
- PDF (409 KB) - Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration
- Supplementary information
Published online: 06 April 2006
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PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E3-ligase MIR FREE
The EMBO Journal (2006), 25, - 1871 - 1882, doi:10.1038/sj.emboj.7601059
- Abstract - PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E: 3: -ligase MIR
- Full text
- PDF (873 KB) - PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E: 3: -ligase MIR
- Supplementary information
Published online: 13 April 2006
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Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2
The EMBO Journal (2006), 25, - 1883 - 1894, doi:10.1038/sj.emboj.7601077
- Abstract - Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2
- Full text
- PDF (308 KB) - Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2
- Supplementary information
Published online: 06 April 2006
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Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression FREE
The EMBO Journal (2006), 25, - 1895 - 1905, doi:10.1038/sj.emboj.7601085
- Abstract - Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression
- Full text
- PDF (278 KB) - Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression
- Supplementary information
Published online: 20 April 2006
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SUMO conjugation attenuates the activity of the gypsy chromatin insulator FREE
The EMBO Journal (2006), 25, - 1906 - 1914, doi:10.1038/sj.emboj.7601068
- Abstract - SUMO conjugation attenuates the activity of the : gypsy: chromatin insulator
- Full text
- PDF (356 KB) - SUMO conjugation attenuates the activity of the : gypsy: chromatin insulator
Published online: 20 April 2006
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Cockayne syndrome B protein regulates the transcriptional program after UV irradiation FREE
The EMBO Journal (2006), 25, - 1915 - 1923, doi:10.1038/sj.emboj.7601071
- Abstract - Cockayne syndrome B protein regulates the transcriptional program after UV irradiation
- Full text
- PDF (299 KB) - Cockayne syndrome B protein regulates the transcriptional program after UV irradiation
Published online: 06 April 2006
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Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release FREE
The EMBO Journal (2006), 25, - 1924 - 1933, doi:10.1038/sj.emboj.7601076
- Abstract - Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
- Full text
- PDF (449 KB) - Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
- Supplementary information
Published online: 06 April 2006
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Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2
The EMBO Journal (2006), 25, - 1934 - 1944, doi:10.1038/sj.emboj.7601079
- Abstract - Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2
- Full text
- PDF (473 KB) - Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2
- Supplementary information
Published online: 06 April 2006
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The 20S proteasome processes NF-
B1 p105 into p50 in a translation-independent manner
FREE The EMBO Journal (2006), 25, - 1945 - 1956, doi:10.1038/sj.emboj.7601081
- Abstract - The 20S proteasome processes NF-[kappa]B1 p105 into p50 in a translation-independent manner
- Full text
- PDF (279 KB) - The 20S proteasome processes NF-[kappa]B1 p105 into p50 in a translation-independent manner
- Supplementary information
Published online: 13 April 2006
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Definition of the bacterial N-glycosylation site consensus sequence FREE
The EMBO Journal (2006), 25, - 1957 - 1966, doi:10.1038/sj.emboj.7601087
- Abstract - Definition of the bacterial : N-: glycosylation site consensus sequence
- Full text
- PDF (283 KB) - Definition of the bacterial : N-: glycosylation site consensus sequence
- Supplementary information
Published online: 13 April 2006
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Conformational changes in the AAA ATPase p97–p47 adaptor complex FREE
The EMBO Journal (2006), 25, - 1967 - 1976, doi:10.1038/sj.emboj.7601055
- Abstract - Conformational changes in the AAA ATPase p97-p47 adaptor complex
- Full text
- PDF (430 KB) - Conformational changes in the AAA ATPase p97-p47 adaptor complex
- Supplementary information
Published online: 06 April 2006
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The closed structure of presequence protease PreP forms a unique 10 000 Å3 chamber for proteolysis FREE
The EMBO Journal (2006), 25, - 1977 - 1986, doi:10.1038/sj.emboj.7601080
- Abstract - The closed structure of presequence protease PreP forms a unique 10 000 A: 3: chamber for proteolysis
- Full text
- PDF (575 KB) - The closed structure of presequence protease PreP forms a unique 10 000 A: 3: chamber for proteolysis
- Supplementary information
Published online: 06 April 2006
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A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2–Dpb11 FREE
The EMBO Journal (2006), 25, - 1987 - 1996, doi:10.1038/sj.emboj.7601075
- Abstract - A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11
- Full text
- PDF (269 KB) - A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11
- Supplementary information
Published online: 13 April 2006
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An aging pathway controls the TrkA to p75NTR receptor switch and amyloid
-peptide generation
The EMBO Journal (2006), 25, - 1997 - 2006, doi:10.1038/sj.emboj.7601062
- Abstract - An aging pathway controls the TrkA to p75: NTR: receptor switch and amyloid [beta]-peptide generation
- Full text
- PDF (447 KB) - An aging pathway controls the TrkA to p75: NTR: receptor switch and amyloid [beta]-peptide generation
- Supplementary information
Published online: 13 April 2006
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Role of SGT1 in resistance protein accumulation in plant immunity FREE
The EMBO Journal (2006), 25, - 2007 - 2016, doi:10.1038/sj.emboj.7601084
- Abstract - Role of SGT1 in resistance protein accumulation in plant immunity
- Full text
- PDF (548 KB) - Role of SGT1 in resistance protein accumulation in plant immunity
- Supplementary information
Published online: 13 April 2006
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Analysis of KaiA–KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods FREE
The EMBO Journal (2006), 25, - 2017 - 2028, doi:10.1038/sj.emboj.7601086
- Abstract - Analysis of KaiA-KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods
- Full text
- PDF (670 KB) - Analysis of KaiA-KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods
- Supplementary information
Published online: 20 April 2006
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Antithrombin–S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation FREE
The EMBO Journal (2006), 25, - 2029 - 2037, doi:10.1038/sj.emboj.7601089
- Abstract - Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation
- Full text
- PDF (400 KB) - Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation
- Supplementary information
Published online: 13 April 2006
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Erratum
Top of pageStructural evidence for induced fit and a mechanism for sugar/H+ symport in LacY FREE
The EMBO Journal (2006), 25, - 2038, doi:10.1038/sj.emboj.7601072
