Table of Contents

Volume 26, Number 5
07 March 2007

pp 1199-1473

Pink ball � A resting flamingo in Hagenbecks Tierpark in Hamburg, Germany. The photographer, Vladimir Prassolov, is a professor at the Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. His hobbies are bird watching and photography. This image won the first prize in the EMBO Journal�s recent contest for the best non-scientific cover image for 2007.

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• Articles

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  • A Hip1R–cortactin complex negatively regulates actin assembly associated with endocytosis FREE

    Christophe Le Clainche, Barbara S Pauly, Claire X Zhang, Åsa E Y Engqvist-Goldstein, Kimberley Cunningham and David G Drubin

    The EMBO Journal (2007), 26, - 1199 - 1210, doi:10.1038/sj.emboj.7601576

    • Abstract - A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis
    • Full text
    • PDF (686 KB) - A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis
    • Supplementary information

    Published online: 22 February 2007

    Subject Categories:

    • Membranes and Transport | Cell and Tissue Architecture

  • Rhomboid cleaves Star to regulate the levels of secreted Spitz

    Rachel Tsruya, Alexandra Wojtalla, Shari Carmon, Shaul Yogev, Aderet Reich, Eitan Bibi, Gunter Merdes, Eyal Schejter and Ben-Zion Shilo

    The EMBO Journal (2007), 26, - 1211 - 1220, doi:10.1038/sj.emboj.7601581

    • Abstract - Rhomboid cleaves Star to regulate the levels of secreted Spitz
    • Full text
    • PDF (435 KB) - Rhomboid cleaves Star to regulate the levels of secreted Spitz

    Published online: 15 February 2007

    Subject Categories:

    • Membranes and Transport | Development

  • Extracellular heat shock protein-90: linking hypoxia to skin cell motility and wound healing

    Wei Li, Yong Li, Shengxi Guan, Jianhua Fan, Chieh-Fang Cheng, Alexandra M Bright, Cindi Chinn, Mei Chen and David T Woodley

    The EMBO Journal (2007), 26, - 1221 - 1233, doi:10.1038/sj.emboj.7601579

    • Abstract - Extracellular heat shock protein-90[alpha]: linking hypoxia to skin cell motility and wound healing
    • Full text
    • PDF (508 KB) - Extracellular heat shock protein-90[alpha]: linking hypoxia to skin cell motility and wound healing
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Cell and Tissue Architecture | Signal Transduction

  • C-terminal Src kinase controls development and maintenance of mouse squamous epithelia FREE

    Reiko Yagi, Satoshi Waguri, Yasuyuki Sumikawa, Shigeyuki Nada, Chitose Oneyama, Satoshi Itami, Christian Schmedt, Yasuo Uchiyama and Masato Okada

    The EMBO Journal (2007), 26, - 1234 - 1244, doi:10.1038/sj.emboj.7601595

    • Abstract - C-terminal Src kinase controls development and maintenance of mouse squamous epithelia
    • Full text
    • PDF (601 KB) - C-terminal Src kinase controls development and maintenance of mouse squamous epithelia
    • Supplementary information

    Published online: 15 February 2007

    Subject Category:

    • Signal Transduction

  • Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38 in abrogating myoblast proliferation FREE

    Eusebio Perdiguero, Vanessa Ruiz-Bonilla, Lionel Gresh, Lijian Hui, Esteban Ballestar, Pedro Sousa-Victor, Bernat Baeza-Raja, Mercè Jardí, Anna Bosch-Comas, Manel Esteller, Carme Caelles, Antonio L Serrano, Erwin F Wagner and Pura Muñoz-Cánoves

    The EMBO Journal (2007), 26, - 1245 - 1256, doi:10.1038/sj.emboj.7601587

    • Abstract - Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38[alpha] in abrogating myoblast proliferation
    • Full text
    • PDF (463 KB) - Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38[alpha] in abrogating myoblast proliferation
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Signal Transduction | Differentiation and Death

  • Cytotoxicity of TNF is regulated by integrin-mediated matrix signaling FREE

    Chih-Chiun Chen, Jennifer L Young, Ricardo I Monzon, Ningyu Chen, Viktor Todorovi and Lester F Lau

    The EMBO Journal (2007), 26, - 1257 - 1267, doi:10.1038/sj.emboj.7601596

    • Abstract - Cytotoxicity of TNF[alpha] is regulated by integrin-mediated matrix signaling
    • Full text
    • PDF (446 KB) - Cytotoxicity of TNF[alpha] is regulated by integrin-mediated matrix signaling
    • Supplementary information

    Published online: 22 February 2007

    Subject Categories:

    • Signal Transduction | Differentiation and Death

  • The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development FREE

    Richard Grose, Vera Fantl, Sabine Werner, Athina-Myrto Chioni, Monika Jarosz, Robert Rudling, Barbara Cross, Ian R Hart and Clive Dickson

    The EMBO Journal (2007), 26, - 1268 - 1278, doi:10.1038/sj.emboj.7601583

    • Abstract - The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development
    • Full text
    • PDF (473 KB) - The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Signal Transduction | Molecular Biology of Disease

  • A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere FREE

    Yasuhide Okamoto, Megumi Nakano, Jun-ichirou Ohzeki, Vladimir Larionov and Hiroshi Masumoto

    The EMBO Journal (2007), 26, - 1279 - 1291, doi:10.1038/sj.emboj.7601584

    • Abstract - A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere
    • Full text
    • PDF (353 KB) - A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere
    • Supplementary information

    Published online: 22 February 2007

    Subject Category:

    • Chromatin and Transcription

  • Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12R2 expression during human Th1 cell differentiation FREE

    Fabrice A Letimier, Nadia Passini, Sona Gasparian, Elisabetta Bianchi and Lars Rogge

    The EMBO Journal (2007), 26, - 1292 - 1302, doi:10.1038/sj.emboj.7601586

    • Abstract - Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12R[beta]2 expression during human Th1 cell differentiation
    • Full text
    • PDF (373 KB) - Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12R[beta]2 expression during human Th1 cell differentiation
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Chromatin and Transcription | Immunology

  • Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin FREE

    Georgia Xouri, Anthony Squire, Maria Dimaki, Bart Geverts, Peter J Verveer, Stavros Taraviras, Hideo Nishitani, Adriaan B Houtsmuller, Philippe I H Bastiaens and Zoi Lygerou

    The EMBO Journal (2007), 26, - 1303 - 1314, doi:10.1038/sj.emboj.7601597

    • Abstract - Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin
    • Full text
    • PDF (366 KB) - Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin
    • Supplementary information

    Published online: 22 February 2007

    Subject Category:

    • Cell Cycle

  • Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast FREE

    Peter Meister, Angela Taddei, Aaron Ponti, Giuseppe Baldacci and Susan M Gasser

    The EMBO Journal (2007), 26, - 1315 - 1326, doi:10.1038/sj.emboj.7601538

    • Abstract - Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast
    • Full text
    • PDF (396 KB) - Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Cell Cycle | Genomic and Computational Biology

  • Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast FREE

    Makoto Hayashi, Yuki Katou, Takehiko Itoh, Mitsutoshi Tazumi, Yoshiki Yamada, Tatsuro Takahashi, Takuro Nakagawa, Katsuhiko Shirahige and Hisao Masukata

    The EMBO Journal (2007), 26, - 1327 - 1339, doi:10.1038/sj.emboj.7601585

    • Abstract - Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast
    • Full text
    • PDF (790 KB) - Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Cell Cycle | Genomic and Computational Biology

  • Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability FREE

    Massimo Bogliolo, Alex Lyakhovich, Elsa Callén, Maria Castellà, Enrico Cappelli, María J Ramírez, Amadeu Creus, Ricard Marcos, Reinhard Kalb, Kornelia Neveling, Detlev Schindler and Jordi Surrallés

    The EMBO Journal (2007), 26, - 1340 - 1351, doi:10.1038/sj.emboj.7601574

    • Abstract - Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability
    • Full text
    • PDF (345 KB) - Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

    Published online: 15 February 2007

    Subject Category:

    • Genome Stability and Dynamics

  • Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes FREE

    Yufuko Akamatsu, Yasuhiro Tsutsui, Takashi Morishita, MD Shahjahan P Siddique, Yumiko Kurokawa, Mitsunori Ikeguchi, Fumiaki Yamao, Benoit Arcangioli and Hiroshi Iwasaki

    The EMBO Journal (2007), 26, - 1352 - 1362, doi:10.1038/sj.emboj.7601582

    • Abstract - Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes
    • Full text
    • PDF (389 KB) - Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes
    • Supplementary information

    Published online: 15 February 2007

    Subject Category:

    • Genome Stability and Dynamics

  • AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis FREE

    Elisabeth P Carpenter, Anne Corbett, Hellen Thomson, Jolanta Adacha, Kirsten Jensen, Julien Bergeron, Ioannis Kasampalidis, Rachel Exley, Megan Winterbotham, Christoph Tang, Geoff S Baldwin and Paul Freemont

    The EMBO Journal (2007), 26, - 1363 - 1372, doi:10.1038/sj.emboj.7601593

    • Abstract - AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis
    • Full text
    • PDF (337 KB) - AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis
    • Supplementary information

    Published online: 22 February 2007

    Subject Categories:

    • Genome Stability and Dynamics | Microbiology and Pathogens

  • Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1 FREE

    Toshihiko Toyofuku, Masanori Yabuki, Junko Kamei, Motohiro Kamei, Nobuhiko Makino, Atsushi Kumanogoh and Masatsugu Hori

    The EMBO Journal (2007), 26, - 1373 - 1384, doi:10.1038/sj.emboj.7601589

    • Abstract - Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1
    • Full text
    • PDF (410 KB) - Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1
    • Supplementary information

    Published online: 22 February 2007

    Subject Categories:

    • Cell and Tissue Architecture | Development

  • Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation FREE

    N Bhutani, P Venkatraman and A L Goldberg

    The EMBO Journal (2007), 26, - 1385 - 1396, doi:10.1038/sj.emboj.7601592

    • Abstract - Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
    • Full text
    • PDF (330 KB) - Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
    • Supplementary information

    Published online: 22 February 2007

    Subject Categories:

    • Proteins | Molecular Biology of Disease

  • Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation FREE

    Christian Proepper, Svenja Johannsen, Stefan Liebau, Janine Dahl, Bianca Vaida, Juergen Bockmann, Michael R Kreutz, Eckart D Gundelfinger and Tobias M Boeckers

    The EMBO Journal (2007), 26, - 1397 - 1409, doi:10.1038/sj.emboj.7601569

    • Abstract - Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation
    • Full text
    • PDF (609 KB) - Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation
    • Supplementary information

    Published online: 15 February 2007

    Subject Category:

    • Neuroscience

  • Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity FREE

    Jens C Schwamborn, Myriam Müller, Annemarie HM Becker and Andreas W Püschel

    The EMBO Journal (2007), 26, - 1410 - 1422, doi:10.1038/sj.emboj.7601580

    • Abstract - Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity
    • Full text
    • PDF (403 KB) - Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity
    • Supplementary information

    Published online: 22 February 2007

    Subject Categories:

    • Cell and Tissue Architecture | Neuroscience

  • Trogocytosis-based generation of suppressive NK cells FREE

    Julien Caumartin, Benoit Favier, Marina Daouya, Christine Guillard, Philippe Moreau, Edgardo D Carosella and Joel LeMaoult

    The EMBO Journal (2007), 26, - 1423 - 1433, doi:10.1038/sj.emboj.7601570

    • Abstract - Trogocytosis-based generation of suppressive NK cells
    • Full text
    • PDF (319 KB) - Trogocytosis-based generation of suppressive NK cells
    • Supplementary information

    Published online: 22 February 2007

    Subject Category:

    • Immunology

  • Pseudomonas syringae pv. tomato hijacks the Arabidopsis abscisic acid signalling pathway to cause disease FREE

    Marta de Torres-Zabala, William Truman, Mark H Bennett, Guillaume Lafforgue, John W Mansfield, Pedro Rodriguez Egea, Laszlo Bögre and Murray Grant

    The EMBO Journal (2007), 26, - 1434 - 1443, doi:10.1038/sj.emboj.7601575

    • Abstract - Pseudomonas syringae: pv. : tomato: hijacks the : Arabidopsis: abscisic acid signalling pathway to cause disease
    • Full text
    • PDF (431 KB) - Pseudomonas syringae: pv. : tomato: hijacks the : Arabidopsis: abscisic acid signalling pathway to cause disease
    • Supplementary information

    Published online: 15 February 2007

    Subject Category:

    • Plant Biology

  • The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus FREE

    Régis Hallez, Johann Mignolet, Vincent Van Mullem, Maxime Wery, Jean Vandenhaute, Jean-Jacques Letesson, Christine Jacobs-Wagner and Xavier De Bolle

    The EMBO Journal (2007), 26, - 1444 - 1455, doi:10.1038/sj.emboj.7601577

    • Abstract - The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in : Brucella abortus
    • Full text
    • PDF (471 KB) - The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in : Brucella abortus
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Differentiation and Death | Microbiology and Pathogens

  • Bcr-Abl stabilizes -catenin in chronic myeloid leukemia through its tyrosine phosphorylation FREE

    Addolorata Maria Luce Coluccia, Angelo Vacca, Mireia Duñach, Luca Mologni, Sara Redaelli, Victor H Bustos, Daniela Benati, Lorenzo A Pinna and Carlo Gambacorti-Passerini

    The EMBO Journal (2007), 26, - 1456 - 1466, doi:10.1038/sj.emboj.7601485

    • Abstract - Bcr-Abl stabilizes [beta]-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
    • Full text
    • PDF (541 KB) - Bcr-Abl stabilizes [beta]-catenin in chronic myeloid leukemia through its tyrosine phosphorylation

    Published online: 22 February 2007

    Subject Category:

    • Molecular Biology of Disease

  • Thylakoid membrane perforations and connectivity enable intracellular traffic in cyanobacteria

    Reinat Nevo, Dana Charuvi, Eyal Shimoni, Rakefet Schwarz, Aaron Kaplan, Itzhak Ohad and Ziv Reich

    The EMBO Journal (2007), 26, - 1467 - 1473, doi:10.1038/sj.emboj.7601594

    • Abstract - Thylakoid membrane perforations and connectivity enable intracellular traffic in cyanobacteria
    • Full text
    • PDF (431 KB) - Thylakoid membrane perforations and connectivity enable intracellular traffic in cyanobacteria
    • Supplementary information

    Published online: 15 February 2007

    Subject Categories:

    • Plant Biology | Structural Biology

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