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Welcome to EMBO reports

The EMBO reports special issue on The Future Of Our Species is available online. Global climate change, space exploration, disease, genetic enhancement, evolution and extended lifespans are just some of the topics addressed by the authors. Humankind is facing both its greatest challenges and its biggest opportunities; how we deal with each may well determine the future of our species.

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Volume 10, Number 1
(January 2009)
ISSN 1469 - 221X

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Measures of scientific quality

An interview with John Gearhart

Science and Society in full...

Arrestins as adaptors for endocytosis

Control of protein degradation in neurons

Reviews in full...

Redox-dependent yeast proteasome regulation
Sollner and colleagues show that the dimeric, flavin-dependent quinone reductase Lot6p binds to the 20S proteasome and that it regulates both the stability and localization of the transcription factor Yap4p in a redox-dependent manner. They suggest that the Lot6p-proteasome complex can be regarded as a redox switch in which the quinone reductase acts as a sensor for oxidative stress.

Senescence and ageing in ku80^-/- mice lacking p21
Premature cellular senescence in culture has often been shown to correlate with mammalian premature ageing syndromes and is recognized as a counterpart of organismal ageing. However, the report by Zhao et al shows that while the loss of p21 in ku80^-/- mice impedes premature senescence in culture, it fails to rescue overall organismal ageing. The compromised lifespan of ku80^-/-p21^-/- mice is not attributable to the increased tumorigenesis as found in ku80^-/-p53^-/- mice.

AICD regulates amyloid beta removal

The Turner group study provides insight into the regulation of a metalloprotease that is able to cleave amyloid deposits in the brain. The authors reveal that both the intracellular domain of the amyloid precursor protein (AICD) and histone acetylation control the expression of the metalloprotease neprilysin. ChIP assays are elegantly used to show direct binding of AICD to the neprilysin promoter and the authors thereby settle the long-standing controversy of whether AICD plays a direct role in neprilysin activation.

Scientific Reports in full...

Science and Society Special Issue
Volume 9, July 2008

The future of our species

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The EMBO Journal is a print and online publication dedicated to providing a variety of complete and rapidly published articles in all areas of molecular biology. It is one of the most highly cited journals, reflected in its latest impact factor of 8.662*

*Journal Citation Reports, Thomson Reuters 2008

MEMBRANES & TRANSPORT | PLANT BIOLOGY

Rice OsHKT2;1 transporter mediates large Na⁺ influx component into K⁺-starved roots for growth

MICROBIOLOGY & PATHOGENS

HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

8 January 2009



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