The EMBO reports special issue on The Future Of Our Species is available online. Global climate change, space exploration, disease, genetic enhancement, evolution and extended lifespans are just some of the topics addressed by the authors. Humankind is facing both its greatest challenges and its biggest opportunities; how we deal with each may well determine the future of our species.
IL-33 attachment to chromatin The Girard lab continues its work on nuclear IL-33 and shows a curious mimicry between the cytokine and Kaposi's sarcoma associated herpesvirus. IL-33 uses a short peptide to bind the acidic pocket of nucleosomes in a similar manner to the KSHV LANA anchoring of the viral genome to mitotic chromosomes.
PP4 is a γH2AX phosphatase Phosphorylation of histone H2AX is a crucial event in the DNA double-strand breaks response. However, its dephosphorylation is less understood and here Durocher et al unravel the contribution of PP4 to dephosphorylation of H2AX and its role at the G2/M checkpoint arrest.
p38α prevents liver failure Using p38α deficient mice livers, this study demonstrates the role of the MAPK in protecting the liver from LPS/TNF-induced failure. By blocking JNK, p38α collaborates with IKK2 to prevent endotoxin-induced hepatocyte apoptosis.
The EMBO Journal is a print and online publication dedicated to providing a variety of complete and rapidly published articles in all areas of molecular biology. It is one of the most highly cited journals, reflected in its latest impact factor of 8.662*