ADVANCE ONLINE PUBLICATION

The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
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November 5 2009

Original Articles

Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours

C T Hiley, M Yuan, N R Lemoine and Y Wang

Gene Ther advance online publication, November 5, 2009; doi:10.1038/gt.2009.132

In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors

C Mueller, M S Strayer, J Sirninger, S Braag, F Branco, J-P Louboutin, T R Flotte and D S Strayer

Gene Ther advance online publication, November 5, 2009; doi:10.1038/gt.2009.137

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October 29 2009

Letter to the Editor

Proliferating NK cells in response to IL-15 do not upregulate surface B220 in vivo

O Murillo, M C Ochoa, A Arina, I Gabari, J Dubrot, S Hervas-Stubbs and I Melero

Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.139

Original Articles

DNA prime–protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice

H Davtyan, M Mkrtichyan, N Movsesyan, I Petrushina, G Mamikonyan, D H Cribbs, M G Agadjanyan and A Ghochikyan

Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.140

A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating bold gamma-retroviral vectors using targeted integration

R Loew, Y Meyer, K Kuehlcke, L Gama-Norton, D Wirth, H Hauser, S Stein, M Grez, S Thornhill, A Thrasher, C Baum and A Schambach

Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.134

Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K

P Maier, I Spier, S Laufs, M R Veldwijk, S Fruehauf, F Wenz and W J Zeller

Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.133

DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes

M J Riedel, D F Gaddy, A Asadi, P D Robbins and T J Kieffer

Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.143

Short Communications

SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol

P Laje, P W Zoltick and A W Flake

Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.138

Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform

S de Silva, M A Mastrangelo, L T Lotta Jr, C A Burris, H J Federoff and W J Bowers

Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.144

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October 22 2009

Review

Integrase-defective lentiviral vectors: progress and applications

M B Banasik and P B McCray Jr

Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.135

Original Articles

Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo

M A Kutzler, K A Kraynyak, S J Nagle, R M Parkinson, D Zharikova, M Chattergoon, H Maguire, K Muthumani, K Ugen and D B Weiner

Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.112

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors

T Maetzig, M Galla, M H Brugman, R Loew, C Baum and A Schambach

Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.129

Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity

L E Woodard, R T Hillman, A Keravala, S Lee and M P Calos

Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.136

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October 15 2009

Original Articles

In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase

J L Gori, X Tian, D Swanson, R Gunther, L D Shultz, R S McIvor and D S Kaufman

Gene Ther advance online publication, October 15, 2009; doi:10.1038/gt.2009.131

Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment

P C Huszthy, H Immervoll, J Wang, D Goplen, H Miletic, G E Eide and R Bjerkvig

Gene Ther advance online publication, October 15, 2009; doi:10.1038/gt.2009.130

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October 8 2009

Original Article

Targeting human glioma cells using HSV-1 amplicon peptide display vector

I A W Ho, L Miao, K C Sia, G Y Wang, K M Hui and P Y P Lam

Gene Ther advance online publication, October 8, 2009; doi:10.1038/gt.2009.128

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October 1 2009

Original Article

The HSV-2 mutant DeltaPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins

A G Colunga, J M Laing and L Aurelian

Gene Ther advance online publication, October 1, 2009; doi:10.1038/gt.2009.126

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September 24 2009

Review

Progress and prospects: gene therapy for inherited immunodeficiencies

W Qasim, H B Gaspar and A J Thrasher

Gene Ther advance online publication, September 24, 2009; doi:10.1038/gt.2009.127

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September 17 2009

News and Commentary

A vaccine that delivers rather than induces antibodies FREE

N L Letvin

Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.121

Original Articles

A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expression

K Inoue, T Sone, C Oneyama, F Nishiumi, H Kishine, Y Sasaki, T Andoh, M Okada, J D Chesnut and F Imamoto

Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.105

AAV5-mediated gene transfer to the parotid glands of non-human primates

A Voutetakis, C Zheng, A P Cotrim, F Mineshiba, S Afione, N Roescher, W D Swaim, M Metzger, M A Eckhaus, R E Donahue, C E Dunbar, J A Chiorini and B J Baum

Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.123

Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys

H-B Wang, A Kondo, A Yoshida, S Yoshizaki, S Abe, L-L Bao, N Mizuki, M Ichino, D Klinman, K Okuda and M Shimada

Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.122

Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino

B Wu, P Lu, E Benrashid, S Malik, J Ashar, T J Doran and Q L Lu

Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.120

Short Communication

The impact of antigen expression in antigen-presenting cells on humoral immune responses against the transgene product

Y Feng, F Jacobs, E Van Craeyveld, J Lievens, J Snoeys, S Van Linthout and B De Geest

Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.125

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September 10 2009

Original Articles

PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration

P-C Chang, Y-J Seol, J A Cirelli, G Pellegrini, Q Jin, L M Franco, S A Goldstein, L A Chandler, B Sosnowski and W V Giannobile

Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.117

Suicide gene therapy on spontaneous canine melanoma: correlations between in vivo tumors and their derived multicell spheroids in vitro

M L Gil-Cardeza, M S Villaverde, G L Fiszman, N A Altamirano, R A Cwirenbaum, G C Glikin and L M E Finocchiaro

Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.107

Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo

H-P Kiem, R A Wu, G Sun, D von Laer, J J Rossi and G D Trobridge

Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.118

Therapeutic potential of genetically modified adult stem cells for osteopenia

S Kumar, T R Nagy and S Ponnazhagan

Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.116

High efficiency non-viral transfection of retinal and iris pigment epithelial cells with pigment epithelium-derived factor

G Thumann, M Stöcker, C Maltusch, A K Salz, S Barth, P Walter and S Johnen

Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.124

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September 3 2009

Original Articles

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo

M Centlivre, X Zhou, S M Pouw, K Weijer, W Kleibeuker, A T Das, B Blom, J Seppen, B Berkhout and N Legrand

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.109

The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors

M Endo, T Henriques-Coelho, P W Zoltick, D H Stitelman, W H Peranteau, A Radu and A W Flake

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.115

Delivering multiple gene products in the brain from a single adeno-associated virus vector

S B Foti, R J Samulski and T J McCown

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.106

Neuroprotection using gene therapy to induce vascular endothelial growth factor-A expression

S A Sakowski, S B Heavener, J S Lunn, K Fung, S S Oh, S K Spratt, N D Hogikyan and E L Feldman

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.111

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints

L H Vandenberghe, E Breous, H-J Nam, G Gao, R Xiao, A Sandhu, J Johnston, Z Debyser, M Agbandje-McKenna and J M Wilson

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.101

Fatty acid–spermine conjugates as DNA carriers for nonviral in vivo gene delivery

J R Viola, H Leijonmarck, O E Simonson, I I Oprea, R Frithiof, P Purhonen, P M D Moreno, K E Lundin, R Strömberg and C I E Smith

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.108

AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease

Y-Q Xue, B-F Ma, L-R Zhao, J B Tatom, B Li, L-X Jiang, R L Klein and W-M Duan

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.113

Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein

K Yang, K Sun, K N Srinivasan, J Salmon, E T Marques, J Xu and J T August

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.92

Short Communication

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

C Towne, B L Schneider, D Kieran, D E Redmond Jr and P Aebischer

Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.119

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August 27 2009

Original Articles

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses

J J Rojas, M Cascallo, S Guedan, A Gros, J Martinez-Quintanilla, A Hemminki and R Alemany

Gene Ther advance online publication, August 27, 2009; doi:10.1038/gt.2009.103

Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations

X Sun, B Pawlyk, X Xu, X Liu, O V Bulgakov, M Adamian, M A Sandberg, S C Khani, M-H Tan, A J Smith, R R Ali and T Li

Gene Ther advance online publication, August 27, 2009; doi:10.1038/gt.2009.104

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August 20 2009

Letter to the Editor

Identification of the immunodominant cytotoxic T-cell epitope of human -1 antitrypsin

E Breous, S Somanathan and J M Wilson

Gene Ther advance online publication, August 20, 2009; doi:10.1038/gt.2009.100

Short Communication

Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures

B J Passer, C-l Wu, S Wu, S D Rabkin and R L Martuza

Gene Ther advance online publication, August 20, 2009; doi:10.1038/gt.2009.94

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August 13 2009

Original Article

Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope

M Matsuda, T Yamamoto, A Matsumura and Y Kaneda

Gene Ther advance online publication, August 13, 2009; doi:10.1038/gt.2009.99

Short Communication

Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice

P Trionfini, S Tomasoni, M Galbusera, D Motto, L Longaretti, D Corna, G Remuzzi and A Benigni

Gene Ther advance online publication, August 13, 2009; doi:10.1038/gt.2009.98

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August 6 2009

Original Article

Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation

M A Sadat, S Dirscherl, L Sastry, J Dantzer, N Pech, S Griffin, T Hawkins, Y Zhao, C N Barese, S Cross, A Orazi, C An, W S Goebel, M C Yoder, X Li, M Grez, K Cornetta, S D Mooney and M C Dinauer

Gene Ther advance online publication, August 6, 2009; doi:10.1038/gt.2009.96

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July 30 2009

Original Articles

rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions

M Cucchiarini, S Schetting, E F Terwilliger, D Kohn and H Madry

Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.91

Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen

S Guo, J Xu, W Denning and Z Hel

Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.93

Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid

B Jullienne, F Vigant, E Muth, R Chaligné, C Bouquet, S Giraudier, M Perricaudet and K Benihoud

Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.97

Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis

X Yao, Y Yoshioka, T Morishige, Y Eto, H Watanabe, Y Okada, H Mizuguchi, Y Mukai, N Okada and S Nakagawa

Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.95

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July 23 2009

Original Articles

Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma

K Aravindaram, H-H Yu, C-W Lan, P-H Wang, Y-H Chen, H-M Chen, H Yagita and N-S Yang

Gene Ther advance online publication, July 23, 2009; doi:10.1038/gt.2009.90

Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues

A Bello, K Tran, A Chand, M Doria, M Allocca, M Hildinger, D Beniac, C Kranendonk, A Auricchio and G P Kobinger

Gene Ther advance online publication, July 23, 2009; doi:10.1038/gt.2009.82

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July 9 2009

Original Article

Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice

D M McCarty, J DiRosario, K Gulaid, J Muenzer and H Fu

Gene Ther advance online publication, July 9, 2009; doi:10.1038/gt.2009.85

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