ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
October 29 2009 |
October 22 2009 |
October 15 2009 |
October 8 2009 |
October 1 2009 |
September 24 2009 |
September 17 2009 |
September 10 2009 |
September 3 2009 |
August 27 2009 |
August 20 2009 |
August 13 2009 |
August 6 2009 |
July 30 2009 |
July 23 2009 |
July 9 2009
November 5 2009
Original Articles
Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours
C T Hiley, M Yuan, N R Lemoine and Y Wang
Gene Ther advance online publication, November 5, 2009; doi:10.1038/gt.2009.132
In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors
C Mueller, M S Strayer, J Sirninger, S Braag, F Branco, J-P Louboutin, T R Flotte and D S Strayer
Gene Ther advance online publication, November 5, 2009; doi:10.1038/gt.2009.137
October 29 2009
Letter to the Editor
Proliferating NK cells in response to IL-15 do not upregulate surface B220 in vivo
O Murillo, M C Ochoa, A Arina, I Gabari, J Dubrot, S Hervas-Stubbs and I Melero
Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.139
Original Articles
DNA prime–protein boost increased the titer, avidity and persistence of anti-A
antibodies in wild-type mice
H Davtyan, M Mkrtichyan, N Movsesyan, I Petrushina, G Mamikonyan, D H Cribbs, M G Agadjanyan and A Ghochikyan
Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.140
A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating 
-retroviral vectors using targeted integration
R Loew, Y Meyer, K Kuehlcke, L Gama-Norton, D Wirth, H Hauser, S Stein, M Grez, S Thornhill, A Thrasher, C Baum and A Schambach
Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.134
Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K
P Maier, I Spier, S Laufs, M R Veldwijk, S Fruehauf, F Wenz and W J Zeller
Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.133
DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes
M J Riedel, D F Gaddy, A Asadi, P D Robbins and T J Kieffer
Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.143
Short Communications
SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol
P Laje, P W Zoltick and A W Flake
Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.138
Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform
S de Silva, M A Mastrangelo, L T Lotta Jr, C A Burris, H J Federoff and W J Bowers
Gene Ther advance online publication, October 29, 2009; doi:10.1038/gt.2009.144
October 22 2009
Review
Integrase-defective lentiviral vectors: progress and applications
M B Banasik and P B McCray Jr
Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.135
Original Articles
Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo
M A Kutzler, K A Kraynyak, S J Nagle, R M Parkinson, D Zharikova, M Chattergoon, H Maguire, K Muthumani, K Ugen and D B Weiner
Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.112
Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors
T Maetzig, M Galla, M H Brugman, R Loew, C Baum and A Schambach
Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.129
Effect of nuclear localization and hydrodynamic delivery-induced cell division on 
C31 integrase activity
L E Woodard, R T Hillman, A Keravala, S Lee and M P Calos
Gene Ther advance online publication, October 22, 2009; doi:10.1038/gt.2009.136
October 15 2009
Original Articles
In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase
J L Gori, X Tian, D Swanson, R Gunther, L D Shultz, R S McIvor and D S Kaufman
Gene Ther advance online publication, October 15, 2009; doi:10.1038/gt.2009.131
Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment
P C Huszthy, H Immervoll, J Wang, D Goplen, H Miletic, G E Eide and R Bjerkvig
Gene Ther advance online publication, October 15, 2009; doi:10.1038/gt.2009.130
October 8 2009
Original Article
Targeting human glioma cells using HSV-1 amplicon peptide display vector
I A W Ho, L Miao, K C Sia, G Y Wang, K M Hui and P Y P Lam
Gene Ther advance online publication, October 8, 2009; doi:10.1038/gt.2009.128
October 1 2009
Original Article
The HSV-2 mutant 
PK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins
A G Colunga, J M Laing and L Aurelian
Gene Ther advance online publication, October 1, 2009; doi:10.1038/gt.2009.126
September 24 2009
Review
Progress and prospects: gene therapy for inherited immunodeficiencies
W Qasim, H B Gaspar and A J Thrasher
Gene Ther advance online publication, September 24, 2009; doi:10.1038/gt.2009.127
September 17 2009
News and Commentary
A vaccine that delivers rather than induces antibodies FREE
N L Letvin
Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.121
Original Articles
A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expression
K Inoue, T Sone, C Oneyama, F Nishiumi, H Kishine, Y Sasaki, T Andoh, M Okada, J D Chesnut and F Imamoto
Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.105
AAV5-mediated gene transfer to the parotid glands of non-human primates
A Voutetakis, C Zheng, A P Cotrim, F Mineshiba, S Afione, N Roescher, W D Swaim, M Metzger, M A Eckhaus, R E Donahue, C E Dunbar, J A Chiorini and B J Baum
Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.123
Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys
H-B Wang, A Kondo, A Yoshida, S Yoshizaki, S Abe, L-L Bao, N Mizuki, M Ichino, D Klinman, K Okuda and M Shimada
Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.122
Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino
B Wu, P Lu, E Benrashid, S Malik, J Ashar, T J Doran and Q L Lu
Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.120
Short Communication
The impact of antigen expression in antigen-presenting cells on humoral immune responses against the transgene product
Y Feng, F Jacobs, E Van Craeyveld, J Lievens, J Snoeys, S Van Linthout and B De Geest
Gene Ther advance online publication, September 17, 2009; doi:10.1038/gt.2009.125
September 10 2009
Original Articles
PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration
P-C Chang, Y-J Seol, J A Cirelli, G Pellegrini, Q Jin, L M Franco, S A Goldstein, L A Chandler, B Sosnowski and W V Giannobile
Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.117
Suicide gene therapy on spontaneous canine melanoma: correlations between in vivo tumors and their derived multicell spheroids in vitro
M L Gil-Cardeza, M S Villaverde, G L Fiszman, N A Altamirano, R A Cwirenbaum, G C Glikin and L M E Finocchiaro
Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.107
Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo
H-P Kiem, R A Wu, G Sun, D von Laer, J J Rossi and G D Trobridge
Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.118
Therapeutic potential of genetically modified adult stem cells for osteopenia
S Kumar, T R Nagy and S Ponnazhagan
Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.116
High efficiency non-viral transfection of retinal and iris pigment epithelial cells with pigment epithelium-derived factor
G Thumann, M Stöcker, C Maltusch, A K Salz, S Barth, P Walter and S Johnen
Gene Ther advance online publication, September 10, 2009; doi:10.1038/gt.2009.124
September 3 2009
Original Articles
Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo
M Centlivre, X Zhou, S M Pouw, K Weijer, W Kleibeuker, A T Das, B Blom, J Seppen, B Berkhout and N Legrand
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.109
The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors
M Endo, T Henriques-Coelho, P W Zoltick, D H Stitelman, W H Peranteau, A Radu and A W Flake
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.115
Delivering multiple gene products in the brain from a single adeno-associated virus vector
S B Foti, R J Samulski and T J McCown
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.106
Neuroprotection using gene therapy to induce vascular endothelial growth factor-A expression
S A Sakowski, S B Heavener, J S Lunn, K Fung, S S Oh, S K Spratt, N D Hogikyan and E L Feldman
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.111
Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints
L H Vandenberghe, E Breous, H-J Nam, G Gao, R Xiao, A Sandhu, J Johnston, Z Debyser, M Agbandje-McKenna and J M Wilson
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.101
Fatty acid–spermine conjugates as DNA carriers for nonviral in vivo gene delivery
J R Viola, H Leijonmarck, O E Simonson, I I Oprea, R Frithiof, P Purhonen, P M D Moreno, K E Lundin, R Strömberg and C I E Smith
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.108
AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease
Y-Q Xue, B-F Ma, L-R Zhao, J B Tatom, B Li, L-X Jiang, R L Klein and W-M Duan
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.113
Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein
K Yang, K Sun, K N Srinivasan, J Salmon, E T Marques, J Xu and J T August
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.92
Short Communication
Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6
C Towne, B L Schneider, D Kieran, D E Redmond Jr and P Aebischer
Gene Ther advance online publication, September 3, 2009; doi:10.1038/gt.2009.119
August 27 2009
Original Articles
A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses
J J Rojas, M Cascallo, S Guedan, A Gros, J Martinez-Quintanilla, A Hemminki and R Alemany
Gene Ther advance online publication, August 27, 2009; doi:10.1038/gt.2009.103
Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations
X Sun, B Pawlyk, X Xu, X Liu, O V Bulgakov, M Adamian, M A Sandberg, S C Khani, M-H Tan, A J Smith, R R Ali and T Li
Gene Ther advance online publication, August 27, 2009; doi:10.1038/gt.2009.104
August 20 2009
Letter to the Editor
Identification of the immunodominant cytotoxic T-cell epitope of human -1 antitrypsin
E Breous, S Somanathan and J M Wilson
Gene Ther advance online publication, August 20, 2009; doi:10.1038/gt.2009.100
Short Communication
Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures
B J Passer, C-l Wu, S Wu, S D Rabkin and R L Martuza
Gene Ther advance online publication, August 20, 2009; doi:10.1038/gt.2009.94
August 13 2009
Original Article
Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope
M Matsuda, T Yamamoto, A Matsumura and Y Kaneda
Gene Ther advance online publication, August 13, 2009; doi:10.1038/gt.2009.99
Short Communication
Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice
P Trionfini, S Tomasoni, M Galbusera, D Motto, L Longaretti, D Corna, G Remuzzi and A Benigni
Gene Ther advance online publication, August 13, 2009; doi:10.1038/gt.2009.98
August 6 2009
Original Article
Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation
M A Sadat, S Dirscherl, L Sastry, J Dantzer, N Pech, S Griffin, T Hawkins, Y Zhao, C N Barese, S Cross, A Orazi, C An, W S Goebel, M C Yoder, X Li, M Grez, K Cornetta, S D Mooney and M C Dinauer
Gene Ther advance online publication, August 6, 2009; doi:10.1038/gt.2009.96
July 30 2009
Original Articles
rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and 
-SMA expression in human meniscal lesions
M Cucchiarini, S Schetting, E F Terwilliger, D Kohn and H Madry
Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.91
Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen
S Guo, J Xu, W Denning and Z Hel
Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.93
Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid
B Jullienne, F Vigant, E Muth, R Chaligné, C Bouquet, S Giraudier, M Perricaudet and K Benihoud
Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.97
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis
X Yao, Y Yoshioka, T Morishige, Y Eto, H Watanabe, Y Okada, H Mizuguchi, Y Mukai, N Okada and S Nakagawa
Gene Ther advance online publication, July 30, 2009; doi:10.1038/gt.2009.95
July 23 2009
Original Articles
Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma
K Aravindaram, H-H Yu, C-W Lan, P-H Wang, Y-H Chen, H-M Chen, H Yagita and N-S Yang
Gene Ther advance online publication, July 23, 2009; doi:10.1038/gt.2009.90
Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues
A Bello, K Tran, A Chand, M Doria, M Allocca, M Hildinger, D Beniac, C Kranendonk, A Auricchio and G P Kobinger
Gene Ther advance online publication, July 23, 2009; doi:10.1038/gt.2009.82
