Gene Therapy

‘Recirculating cardiac delivery’ method of gene delivery should be called ‘non-recirculating’ method

C R Bridges

‘Recirculating cardiac delivery’ method of gene delivery should be called ‘non-recirculating’ method

Gene Therapy advance online publication, April 2, 2009. doi:10.1038/gt.2009.35

Author: C R Bridges

QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis

J-U Appelt — 2009-04-23

QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis

Gene Therapy advance online publication, April 23, 2009. doi:10.1038/gt.2009.37

Authors: J-U Appelt, F A Giordano, M Ecker, I Roeder, N Grund, A Hotz-Wagenblatt, G Opelz, W J Zeller, H Allgayer, S Fruehauf & S Laufs

VSV virotherapy improves chemotherapy by triggering apoptosis due to proteasomal degradation of Mcl-1

P Schache — 2009-04-16

VSV virotherapy improves chemotherapy by triggering apoptosis due to proteasomal degradation of Mcl-1

Gene Therapy advance online publication, April 16, 2009. doi:10.1038/gt.2009.39

Authors: P Schache, E Gürlevik, N Strüver, N Woller, N Malek, L Zender, M Manns, T Wirth, F Kühnel & S Kubicka

Efficient lentiviral gene transfer into corneal stroma cells using a femtosecond laser

A-P Bemelmans — 2009-04-23

Efficient lentiviral gene transfer into corneal stroma cells using a femtosecond laser

Gene Therapy advance online publication, April 23, 2009. doi:10.1038/gt.2009.41

Authors: A-P Bemelmans, Y Arsenijevic & F Majo

Effects of ciliary muscle plasmid electrotransfer of TNF-α soluble receptor variants in experimental uveitis

E Touchard — 2009-05-14

Effects of ciliary muscle plasmid electrotransfer of TNF-α soluble receptor variants in experimental uveitis

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.43

Authors: E Touchard, C Bloquel, P Bigey, L Kowalczuc, L Jonet, B Thillaye-Goldenberg, M-C Naud, D Scherman, Y de Kozak, D BenEzra & F Behar-Cohen

Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect

D Kolodkin-Gal — 2009-05-14

Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.44

Authors: D Kolodkin-Gal, Y Edden, Z Hartshtark, L Ilan, A Khalaileh, A J Pikarsky, E Pikarsky, S D Rabkin, A Panet & G Zamir

Asymmetry in siRNA design

D Grimm — 2009-04-30

Asymmetry in siRNA design

Gene Therapy advance online publication, April 30, 2009. doi:10.1038/gt.2009.45

Author: D Grimm

Independent and high-level dual-gene expression in adult stem-progenitor cells from a single lentiviral vector

J Tian — 2009-05-14

Independent and high-level dual-gene expression in adult stem-progenitor cells from a single lentiviral vector

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.46

Authors: J Tian & S T Andreadis

(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery

M U Kaikkonen — 2009-05-14

(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.47

Authors: M U Kaikkonen, H P Lesch, J Pikkarainen, J K Räty, T Vuorio, T Huhtala, M Taavitsainen, T Laitinen, P Tuunanen, O Gröhn, A Närvänen, K J Airenne & S Ylä-Herttuala

Excision repair cross-complementing 1 expression protects against ischemic injury following middle cerebral artery occlusion in the rat brain

K-Y He — 2009-05-14

Excision repair cross-complementing 1 expression protects against ischemic injury following middle cerebral artery occlusion in the rat brain

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.48

Authors: K-Y He, S-Z Yang, D-H Shen, L-M Zhang, S-D Lu & F-Y Sun

Lentiviral vectors with amplified β cell-specific gene expression

K L Shaw — 2009-05-14

Lentiviral vectors with amplified β cell-specific gene expression

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.49

Authors: K L Shaw, E Pais, S Ge, C Hardee, D Skelton, R P Hollis, G M Crooks & D B Kohn

Subconjunctival gene delivery of the transcription factor GA-binding protein delays corneal neovascularization in a mouse model

K C Yoon — 2009-05-07

Subconjunctival gene delivery of the transcription factor GA-binding protein delays corneal neovascularization in a mouse model

Gene Therapy advance online publication, May 7, 2009. doi:10.1038/gt.2009.50

Authors: K C Yoon, J A Bae, H J Park, S K Im, H J Oh, X H Lin, M Y Kim, J H Lee, S E Lee, K Y Ahn & K K Kim

Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage

H J Lee — 2009-06-25

Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage

Gene Therapy advance online publication, June 25, 2009. doi:10.1038/gt.2009.51

Authors: H J Lee, I H Park, H J Kim & S U Kim

Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters

T Husain — 2009-05-21

Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters

Gene Therapy advance online publication, May 21, 2009. doi:10.1038/gt.2009.52

Authors: T Husain, M A Passini, M K Parente, N W Fraser & J H Wolfe

Shortened ALK1 regulatory fragment maintains a specific activity in arteries feeding ischemic tissues

X Li — 2009-05-14

Shortened ALK1 regulatory fragment maintains a specific activity in arteries feeding ischemic tissues

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.53

Authors: X Li, Y Yonenaga & T Seki

Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

P D Peng — 2009-06-04

Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

Gene Therapy advance online publication, June 4, 2009. doi:10.1038/gt.2009.54

Authors: P D Peng, C J Cohen, S Yang, C Hsu, S Jones, Y Zhao, Z Zheng, S A Rosenberg & R A Morgan

Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging

W Aung — 2009-05-21

Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging

Gene Therapy advance online publication, May 21, 2009. doi:10.1038/gt.2009.55

Authors: W Aung, S Hasegawa, M Koshikawa-Yano, T Obata, H Ikehira, T Furukawa, I Aoki & T Saga

Ad5/3-9HIF-Δ24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment

K Guse — 2009-05-14

Ad5/3-9HIF-Δ24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.56

Authors: K Guse, I Diaconu, M Rajecki, M Sloniecka, T Hakkarainen, A Ristimäki, A Kanerva, S Pesonen & A Hemminki

Gene transfer using bovine adeno-associated virus in the guinea pig cochlea

S B Shibata — 2009-05-21

Gene transfer using bovine adeno-associated virus in the guinea pig cochlea

Gene Therapy advance online publication, May 21, 2009. doi:10.1038/gt.2009.57

Authors: S B Shibata, G Di Pasquale, S R Cortez, J A Chiorini & Y Raphael

Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors

B V Jacquet — 2009-05-28

Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors

Gene Therapy advance online publication, May 28, 2009. doi:10.1038/gt.2009.58

Authors: B V Jacquet, M Patel, M Iyengar, H Liang, B Therit, R Salinas-Mondragon, C Lai, J C Olsen, E S Anton & H T Ghashghaei

A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery

C-Y Yu — 2009-05-28

A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery

Gene Therapy advance online publication, May 28, 2009. doi:10.1038/gt.2009.59

Authors: C-Y Yu, Z Yuan, Z Cao, B Wang, C Qiao, J Li & X Xiao

Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies

M Jean — 2009-05-14

Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.60

Authors: M Jean, F Smaoui, M Lavertu, S Méthot, L Bouhdoud, M D Buschmann & A Merzouki

Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse

T K Park — 2009-05-21

Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse

Gene Therapy advance online publication, May 21, 2009. doi:10.1038/gt.2009.61

Authors: T K Park, Z Wu, S Kjellstrom, Y Zeng, R A Bush, P A Sieving & P Colosi

siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model

E Gonzalez-Gonzalez — 2009-05-28

siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model

Gene Therapy advance online publication, May 28, 2009. doi:10.1038/gt.2009.62

Authors: E Gonzalez-Gonzalez, H Ra, R P Hickerson, Q Wang, W Piyawattanametha, M J Mandella, G S Kino, D Leake, A A Avilion, O Solgaard, T C Doyle, C H Contag & R L Kaspar

Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease

P Ranjzad — 2009-05-28

Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease

Gene Therapy advance online publication, May 28, 2009. doi:10.1038/gt.2009.63

Authors: P Ranjzad, H K Salem & P A Kingston

Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells

E Kizana — 2009-06-11

Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells

Gene Therapy advance online publication, June 11, 2009. doi:10.1038/gt.2009.64

Authors: E Kizana, E Cingolani & E Marbán

Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob

H Matsui — 2009-06-11

Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob

Gene Therapy advance online publication, June 11, 2009. doi:10.1038/gt.2009.65

Authors: H Matsui, F Sakurai, S Kurachi, K Tashiro, K Sugio, K Kawabata, K Yamanishi & H Mizuguchi

Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse

M Takanashi — 2009-05-28

Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse

Gene Therapy advance online publication, May 28, 2009. doi:10.1038/gt.2009.66

Authors: M Takanashi, K Oikawa, K Sudo, M Tanaka, K Fujita, A Ishikawa, S Nakae, R L Kaspar, M Matsuzaki, M Kudo & M Kuroda

Transgene-specific host responses in cutaneous gene therapy: the role of cells expressing the transgene

Z Zhang — 2009-05-14

Transgene-specific host responses in cutaneous gene therapy: the role of cells expressing the transgene

Gene Therapy advance online publication, May 14, 2009. doi:10.1038/gt.2009.67

Authors: Z Zhang, C Kuscu & S Ghazizadeh

PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses

P T Sobol — 2009-05-28

PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses

Gene Therapy advance online publication, May 28, 2009. doi:10.1038/gt.2009.68

Authors: P T Sobol, J L Hummel, R M Rodrigues & K L Mossman

In vitro analysis of cidofovir and genetically engineered TK expression as potential approaches for the intervention of ColoAd1-based treatment of cancer

M Bauzon — 2009-05-21

In vitro analysis of cidofovir and genetically engineered TK expression as potential approaches for the intervention of ColoAd1-based treatment of cancer

Gene Therapy advance online publication, May 21, 2009. doi:10.1038/gt.2009.69

Authors: M Bauzon, F Jin, P Kretschmer & T Hermiston

Translational stability for sickle gene therapy

M C Walters — 2009-06-25

Translational stability for sickle gene therapy

Gene Therapy advance online publication, June 25, 2009. doi:10.1038/gt.2009.70

Author: M C Walters

Systemic delivery of AAV8 in utero results in gene expression in diaphragm and limb muscle: treatment implications for muscle disorders

B M Koppanati — 2009-05-28

Systemic delivery of AAV8 in utero results in gene expression in diaphragm and limb muscle: treatment implications for muscle disorders

Gene Therapy advance online publication, May 28, 2009. doi:10.1038/gt.2009.71

Authors: B M Koppanati, J Li, X Xiao & P R Clemens

Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect

J Kim — 2009-06-04

Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect

Gene Therapy advance online publication, June 4, 2009. doi:10.1038/gt.2009.72

Authors: J Kim, P-H Kim, J Y Yoo, A-R Yoon, H J Choi, J Seong, I-W Kim, J-H Kim & C-O Yun

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

A A Hombach — 2009-06-25

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

Gene Therapy advance online publication, June 25, 2009. doi:10.1038/gt.2009.75

Authors: A A Hombach, D Kofler, G Rappl & H Abken

An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation

Z Huang — 2009-06-25

An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation

Gene Therapy advance online publication, June 25, 2009. doi:10.1038/gt.2009.76

Authors: Z Huang & M R King

CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies

S S Seregin — 2009-06-25

CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies

Gene Therapy advance online publication, June 25, 2009. doi:10.1038/gt.2009.77

Authors: S S Seregin, Y A Aldhamen, D M Appledorn, N J Schuldt, A J McBride, M Bujold, S S Godbehere & A Amalfitano

Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain

E Sloane — 2009-07-02

Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain

Gene Therapy advance online publication, July 2, 2009. doi:10.1038/gt.2009.79

Authors: E Sloane, S Langer, B Jekich, J Mahoney, T Hughes, M Frank, W Seibert, G Huberty, B Coats, J Harrison, D Klinman, S Poole, S Maier, K Johnson, R Chavez, L R Watkins, L Leinwand & E Milligan

Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome

Z Zeier — 2009-07-02

Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome

Gene Therapy advance online publication, July 2, 2009. doi:10.1038/gt.2009.83

Authors: Z Zeier, A Kumar, K Bodhinathan, J A Feller, T C Foster & D C Bloom

Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo

H L Li — 2009-07-02

Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo

Gene Therapy advance online publication, July 2, 2009. doi:10.1038/gt.2009.84

Authors: H L Li, X Z Zheng, H P Wang, F Li, Y Wu & L F Du