FOCUS
DENDRITIC CELLS
This focus presents a collection of review and research articles that outline our current understanding of DC heterogeneity, how different populations contribute to T cell responses, and how T cells differentiate and maintain functional diversity. As well as highlighting the recent advances, the accompanying two-part special feature also identifies the gaps in our understanding and the potential this holds for the future.
News and Views
Cross-presentation: avoiding trafficking chaos?
Sudhir Pai Kasturi & Bali Pulendran
Nature Immunology 9, 461 - 463 (01 May 2008); doi:10.1038/ni0508-461
Reviews
Taking dendritic cells into medicine
Ralph M. Steinman & Jacques Banchereau
Nature 449, 419 - 426 (27 Sep 2007); doi:10.1038/nature06175
Steady-state and inflammatory dendritic-cell development
Ken Shortman & Shalin H. Naik
Nat Rev Immunol. 2007 Jan;7(1):19-30; doi:10.1038/nri1996
Dendritic cells in a mature age
Caetano Reis e Sousa
Nat Rev Immunol. 2006 Jun;6(6):476-83; doi:10.1038/nri1845
Dendritic-cell trafficking to lymph nodes through lymphatic vessels
Gwendalyn J. Randolph, Veronique Angeli & Melody A. Swartz
Nat Rev Immunol. 2005 Aug;5(8):617-28; doi:10.1038/nri1670
Original Articles
Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
Tiziana Di Pucchio, Bithi Chatterjee, Anna Smed-Sörensen, Sandra Clayton, Adam Palazzo, Monica Montes, Yaming Xue, Ira Mellman, Jacques Banchereau & John E Connolly
Nature Immunology 9, 551 - 557 (01 May 2008); doi:10.1038/ni.1602
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
Sven Burgdorf, Christian Schölz, Andreas Kautz, Robert Tampé & Christian Kurts
Nature Immunology 9, 558 - 566 (01 May 2008); doi:10.1038/ni.1601
Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches FREE
Anita Sapoznikov, Yael Pewzner-Jung, Vyacheslav Kalchenko, Rita Krauthgamer, Idit Shachar & Steffen Jung
Nature Immunology 2008 Apr;9(4):388-95; doi:10.1038/ni1571
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues FREE
Claudia Waskow, Kang Liu, Guillaume Darrasse-Jèze, Pierre Guermonprez, Florent Ginhoux, Miriam Merad, Tamara Shengelia, Kaihui Yao, Michel Nussenzweig
Nature Immunology 2008 June;9(6):676-683; doi: 10.1038/ni.1615
Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling
Nicholas S Wilson, Louise J Young, Fiona Kupresanin, Shalin H Naik, David Vremec, William R Heath, Shizuo Akira, Ken Shortman, Jeff Boyle, Eugene Maraskovsky, Gabrielle T Belz and José A Villadangos
Immunol Cell Biol 86: 200-205; advance online publication, November 20, 2007; doi:10.1038/sj.icb.7100125
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes FREE
Heather D Hickman, Kazuyo Takeda, Cara N Skon, Faith R Murray, Scott E Hensley, Joshua Loomis, Glen N Barber, Jack R Bennink & Jonathan W Yewdell
Nat Immunol. 2008 Feb;9(2):155-65; doi:10.1038/ni1557
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
Shalin H Naik, Priyanka Sathe, Hae-Young Park, Donald Metcalf, Anna I Proietto, Aleksander Dakic, Sebastian Carotta, Meredith O'Keeffe, Melanie Bahlo, Anthony Papenfuss, Jong-Young Kwak, Li Wu & Ken Shortman
Nat Immunol. 2007 Nov;8(11):1217-26; doi:10.1038/ni1522
Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells
Gabrielle T Belz, Sammy Bedoui, Fiona Kupresanin, Francis R Carbone & William R Heath
Nat Immunol. 2007 Oct;8(10):1060-6; doi:10.1038/ni1505
Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
Dimitris Skokos, Guy Shakhar, Rajat Varma, Janelle C Waite, Thomas O Cameron, Randall L Lindquist, Tanja Schwickert, Michel C Nussenzweig & Michael L Dustin
Nat Immunol. 2007 Aug;8(8):835-44; doi:10.1038/ni1490
Spatial modelling of brief and long interactions between T cells and dendritic cells FREE
Joost B Beltman, Athanasius F M Marée and Rob J de Boer
Immunol Cell Biol 85: 306-314; advance online publication, April 10, 2007; doi:10.1038/sj.icb.7100054
Use of gene profiling to describe a niche for dendritic cell development FREE
Geneviève Despars, Terence J O'Neill and Helen C O'Neill
Immunol Cell Biol 85: 567-570; advance online publication, May 29, 2007; doi:10.1038/sj.icb.7100080
Langerhans cells arise from monocytes in vivo
Florent Ginhoux, Frank Tacke, Veronique Angeli, Milena Bogunovic, Martine Loubeau, Xu-Ming Dai, E Richard Stanley, Gwendalyn J Randolph & Miriam Merad
Nat Immunol. 2006 Mar;7(3):265-73; doi:10.1038/ni1307
