ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
December 18 2008 |
December 11 2008 |
December 4 2008 |
November 27 2008 |
November 20 2008 |
November 13 2008 |
November 6 2008 |
October 30 2008 |
October 23 2008 |
October 16 2008 |
October 9 2008 |
October 2 2008 |
September 25 2008 |
September 18 2008 |
September 11 2008 |
August 28 2008 |
August 21 2008 |
August 7 2008 |
July 31 2008 |
July 17 2008 |
July 10 2008 |
July 3 2008 |
June 26 2008 |
June 12 2008 |
May 29 2008
January 8 2009
Original Articles
Early related or unrelated haematopoietic cell transplantation results in higher overall survival and leukaemia-free survival compared with conventional chemotherapy in high-risk acute myeloid leukaemia patients in first complete remission
N Basara, A Schulze, U Wedding, M Mohren, A Gerhardt, C Junghanss, N Peter, G Dölken, C Becker, S Heyn, C Kliem, T Lange, R Krahl, W Pönisch, H-J Fricke, H G Sayer, H Al-Ali, F Kamprad and D Niederwieser for the East German Study Group Hematology and Oncology (OSHO)
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.352
Fully functional NK cells after unrelated cord blood transplantation
V Beziat, S Nguyen, S Lapusan, B Hervier, N Dhedin, D Bories, M Uzunov, A Boudifa, H Trebeden-Negre, F Norol, Z Marjanovic, J-P Marie, J-P Vernant, P Debre, B Rio and V Vieillard
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.343
A new molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukemia cells
M L De Marchis, M Ballarino, B Salvatori, M C Puzzolo, I Bozzoni and A Fatica
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.372
Is there a role for all-trans retinoic acid in combination with recombinant erythropoetin in myelodysplastic syndromes? A report on 59 cases
R Itzykson, S Ayari, D Vassilief, E Berger, B Slama, N Vey, F Suarez, O Beyne-Rauzy, A Guerci, S Cheze, X Thomas, A Stamatoullas, M Gardembas, F Bauduer, A Kolb, M C Chaury, L Legros, G Damaj, F Chermat, F Dreyfus, P Fenaux and L Ades on behalf of the Groupe Francophone des Myelodysplasies (GFM)
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.362
Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis
X Liu, Q Zhang, D-E Zhang, C Zhou, H Xing, Z Tian, Q Rao, M Wang and J Wang
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.350
Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q- syndrome
O Lopez-Villar, J L Garcia, F M Sanchez-Guijo, C Robledo, E M Villaron, P Hernández-Campo, N Lopez-Holgado, M Diez-Campelo, M V Barbado, J A Perez-Simon, J M Hernández-Rivas, J F San-Miguel and M-C del Cañizo
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.361
The role of survivin2 in primitive hematopoiesis during zebrafish development
A C H Ma, M I S Chung, R Liang and A Y H Leung
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.363
Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations
N Niitsu, M Okamoto, I Miura and M Hirano
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.344
Repression of Gadd45
by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation
M Perugini, C H Kok, A L Brown, C R Wilkinson, D G Salerno, S M Young, S M Diakiw, I D Lewis, T J Gonda and R J D'Andrea
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.349
Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate
A Poggi, S Catellani, A Garuti, I Pierri, M Gobbi and M R Zocchi
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.354
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma
N Raje, T Hideshima, S Mukherjee, M Raab, S Vallet, S Chhetri, D Cirstea, S Pozzi, C Mitsiades, M Rooney, T Kiziltepe, K Podar, Y Okawa, H Ikeda, R Carrasco, P G Richardson, D Chauhan, N C Munshi, S Sharma, H Parikh, B Chabner, D Scadden and K C Anderson
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.378
Molecular recognition of acute myeloid leukemia using aptamers
K Sefah, Z W Tang, D H Shangguan, H Chen, D Lopez-Colon, Y Li, P Parekh, J Martin, L Meng, J A Phillips, Y M Kim and W H Tan
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.335
The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia
H Seifert, B Mohr, C Thiede, U Oelschlägel, U Schäkel, T Illmer, S Soucek, G Ehninger and M Schaich on behalf of the Study Alliance Leukemia (SAL)
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.375
The proportion of childhood leukaemia incidence in Great Britain that may be caused by natural background ionizing radiation
R Wakeford, G M Kendall and M P Little
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.342
KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia
R Willemze, C A Rodrigues, M Labopin, G Sanz, G Michel, G Socié, B Rio, A Sirvent, M Renaud, L Madero, M Mohty, C Ferra, F Garnier, P Loiseau, J Garcia, L Lecchi, G Kögler, Y Beguin, C Navarrete, T Devos, I Ionescu, K Boudjedir, A-L Herr, E Gluckman and V Rocha on behalf of Eurocord-Netcord and Acute Leukaemia Working Party of the EBMT, Paris (F)
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.365
Letters to the Editor
Nuclear entrapment of BCR–ABL by combining imatinib mesylate with leptomycin B does not eliminate CD34+ chronic myeloid leukaemia cells
E K Allan, A Hamilton, S Hatziieremia, P Zhou, H G Jørgensen, P Vigneri and T L Holyoake
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.367
Molecular profile of CD34+ stem/progenitor cells according to JAK2V617F mutation status in essential thrombocythemia
L Catani, R Zini, D Sollazzo, E Ottaviani, A M Vannucchi, S Ferrari, M Baccarani, N Vianelli, R M Lemoli and R Manfredini
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.357
Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis
G Gruber, M Carlet, E Türtscher, B Meister, J A E Irving, C Ploner and R Kofler
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.360
Dexamethasone and the risk for adrenal suppression in multiple myeloma
A C Ng, S K Kumar, S J Russell, S V Rajkumar and M T Drake
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.373
No evidence of frequent association of the JAK2 V617F mutation with acute myocardial infarction in young patients
M Politou, C Zoi, I J Dahabreh, L Rallidis, A Gialeraki, D Loukopoulos and K Zoi
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.368
Sustained major molecular response in the absence of any antileukaemic therapy after dasatinib treatment and autologous peripheral blood stem cell transplantation in a patient with imatinib-resistant myeloblastic-phase chronic myeloid leukaemia
D Rea, E Raffoux, J-M Cayuela, O Maarek and H Dombret
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.376
A second NOTCH1 chromosome rearrangement: t(9;14)(q34.3;q11.2) in T-cell neoplasia
S Suzuki, S Nagel, B Schneider, S Chen, M Kaufmann, K Uozumi, N Arima, H G Drexler and R A F MacLeod
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.366
Exclusion of ABCB8 and ABCB10 as cancer candidate genes in acute myeloid leukemia
L Tang, S M Bergevoet, L E Franssen, T de Witte, J H Jansen, R A P Raymakers and B A van der Reijden
Leukemia advance online publication, January 8, 2009; doi:10.1038/leu.2008.358
December 18 2008
Original Articles
A phase I study of tipifarnib combined with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia aged 60 years and over
J M Brandwein, B F Leber, K Howson-Jan, A D Schimmer, A C Schuh, V Gupta, K W L Yee, J Wright, M Moore, K MacAlpine and M D Minden NCI CTEP Protocol 6670
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.341
The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia
K Giannopoulos, D Mertens, A Bühler, T F E Barth, I Idler, P Möller, A Kröber, J Greiner, S Chocholska, A Dmoszyñska, J Roliñski, H Döhner, S Stilgenbauer and M Schmitt
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.338
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
S Gobessi, L Laurenti, P G Longo, L Carsetti, V Berno, S Sica, G Leone and D G Efremov
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.346
CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy
A Pérez-García, S Brunet, J J Berlanga, M Tormo, J Nomdedeu, R Guardia, J M Ribera, I Heras, A Llorente, M Hoyos, J Esteve, J Besalduch, J Bueno, J Sierra and D Gallardo 'Grupo cooperativo para el estudio y tratamiento de las leucemias agudas y mielodisplasias' (CETLAM)
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.339
Gene expression profiles in differentiating leukemia cells induced by methyl jasmonate are similar to those of cytokinins and methyl jasmonate analogs induce the differentiation of human leukemia cells in primary culture
H Tsumura, M Akimoto, H Kiyota, Y Ishii, H Ishikura and Y Honma
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.347
Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger
T Yamamoto, N Sakaguchi, M Hachiya, F Nakayama, M Yamakawa and M Akashi
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.353
Letters to the Editor
Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells
M Baou, A Jewell, A Muthurania, R G Wickremasinghe, K L Yong, R Carr, P Marsh and J J Murphy
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.340
Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis
K Vandyke, A L Dewar, A N Farrugia, S Fitter, L Bik To, T P Hughes and A C W Zannettino
Leukemia advance online publication, December 18, 2008; doi:10.1038/leu.2008.356
December 11 2008
Letter to the Editor
The B-cell calcium sensor predicts progression of chronic lymphocytic leukemia
C M Hammond, Y Shi, D White, D Cervi, J Tomic and D E Spaner
Leukemia advance online publication, December 11, 2008; doi:10.1038/leu.2008.351
December 4 2008
Letter to the Editor
Early in vivo changes of the transcriptome in Philadelphia chromosome-positive CD34+ cells from patients with chronic myelogenous leukaemia following imatinib therapy
D Bruennert, A Czibere, I Bruns, R Kronenwett, N Gattermann, R Haas and F Neumann
Leukemia advance online publication, December 4, 2008; doi:10.1038/leu.2008.337
November 27 2008
Spotlight Review
Pathogenesis of myeloma bone disease
G D Roodman
Leukemia advance online publication, November 27, 2008; doi:10.1038/leu.2008.336
Review
Inhibitor of apoptosis proteins in hematological malignancies
S Fulda
Leukemia advance online publication, November 27, 2008; doi:10.1038/leu.2008.329
Original Articles
The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed–Sternberg cells
H Knecht, B Sawan, D Lichtensztejn, B Lemieux, R J Wellinger and S Mai
Leukemia advance online publication, November 27, 2008; doi:10.1038/leu.2008.314
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
L L Remsing Rix, U Rix, J Colinge, O Hantschel, K L Bennett, T Stranzl, A Müller, C Baumgartner, P Valent, M Augustin, J H Till and G Superti-Furga
Leukemia advance online publication, November 27, 2008; doi:10.1038/leu.2008.334
November 20 2008
Spotlight Review
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders
A Dispenzieri, R Kyle, G Merlini, J S Miguel, H Ludwig, R Hajek, A Palumbo, S Jagannath, J Blade, S Lonial, M Dimopoulos, R Comenzo, H Einsele, B Barlogie, K Anderson, M Gertz, J L Harousseau, M Attal, P Tosi, P Sonneveld, M Boccadoro, G Morgan, P Richardson, O Sezer, M V Mateos, M Cavo, D Joshua, I Turesson, W Chen, K Shimizu, R Powles, S V Rajkumar and B G M Durie on behalf of the International Myeloma Working Group
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.307
Original Articles
BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold
J Dierov, P V Sanchez, B A Burke, H Padilla-Nash, M E Putt, T Ried and M Carroll
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.308
Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML
I H I M Hollink, C M Zwaan, M Zimmermann, T C J M Arentsen-Peters, R Pieters, J Cloos, G J L Kaspers, S S N de Graaf, J Harbott, U Creutzig, D Reinhardt, M M van den Heuvel-Eibrink and C Thiede
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.313
Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)
I Kotsianidis, I Bouchliou, E Nakou, E Spanoudakis, D Margaritis, A V Christophoridou, A Anastasiades, C Tsigalou, G Bourikas, A Karadimitris and C Tsatalas
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.333
Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia
K Nebral, D Denk, A Attarbaschi, M König, G Mann, O A Haas and S Strehl
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.306
Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study
H A Poirel, M S Cairo, N A Heerema, J Swansbury, A Aupérin, E Launay, W G Sanger, P Talley, S L Perkins, M Raphaël, K McCarthy, R Sposto, M Gerrard, A Bernheim and C Patte on behalf of the FAB/LMB 96 International Study Committee
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.312
Monitoring treatment response of childhood precursor B-cell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytometry: predictive impact of early blast reduction on the remission status after induction
R Ratei, G Basso, M Dworzak, G Gaipa, M Veltroni, P Rhein, A Biondi, M Schrappe, W-D Ludwig and L Karawajew for the AIEOP-BFM-FCM-MRD-Study Group
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.324
Letters to the Editor
Hematolymphoid neoplasms: World Health Organization versus rest of the world
S Gujral
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.327
Investigation of C/EBP
function in human (versus murine) myelopoiesis provides novel insight into the impact of CEBPA mutations in acute myelogenous leukemia (AML)
B Niebuhr, G B Iwanski, M Schwieger, S Roscher, C Stocking and J Cammenga
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.332
Reply to 'What do we mean by sensitivity when we talk about detecting minimal residual disease?' by Steinbach and Debatin
D M Ross, S Branford, J V Melo and T P Hughes
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.330
Reply to Ross et al.
D Steinbach and K-M Debatin
Leukemia advance online publication, November 20, 2008; doi:10.1038/leu.2008.331
November 13 2008
Spotlight Review
Treatment of newly diagnosed myeloma
A Palumbo and S V Rajkumar
Leukemia advance online publication, November 13, 2008; doi:10.1038/leu.2008.325
Original Articles
Telomere length is severely and similarly reduced in JAK2V617F-positive and -negative myeloproliferative neoplasms
L Bernard, C Belisle, L Mollica, S Provost, D-C Roy, D G Gilliland, R L Levine and L Busque
Leukemia advance online publication, November 13, 2008; doi:10.1038/leu.2008.319
A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin, and ARF
N Bolli, M F De Marco, M P Martelli, B Bigerna, A Pucciarini, R Rossi, R Mannucci, N Manes, V Pettirossi, S A Pileri, I Nicoletti and B Falini
Leukemia advance online publication, November 13, 2008; doi:10.1038/leu.2008.326
Post-transcriptional regulation of adapter molecules by IL-10 inhibits TLR-mediated activation of antigen-presenting cells
A Knödler, S M Schmidt, A Bringmann, M M Weck, K M Brauer, T A W Holderried, A-K Heine, F Grünebach and P Brossart
Leukemia advance online publication, November 13, 2008; doi:10.1038/leu.2008.301
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia
V Rocha, R Porcher, J F Fernandes, A Filion, H Bittencourt, W Silva Jr, G Vilela, D L Zanette, C Ferry, J Larghero, A Devergie, P Ribaud, Y Skvortsova, R Tamouza, E Gluckman, G Socie and M A Zago
Leukemia advance online publication, November 13, 2008; doi:10.1038/leu.2008.323
Letter to the Editor
Caspase-independent type III PCD: a new means to modulate cell death in chronic lymphocytic leukemia
H Merle-Béral, S Barbier, G Roué, M Bras, M Sarfati and S A Susin
Leukemia advance online publication, November 13, 2008; doi:10.1038/leu.2008.321
November 6 2008
Reviews
CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers
J A Burger and A Peled
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.299
Treatment of B-cell chronic lymphocytic leukemia with nonchemotherapeutic agents: experience with single-agent and combination therapy
S Faderl, A Ferrajoli, O Frankfurt and A Pettitt
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.322
Original Articles
Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
A L Feldman, M Law, E D Remstein, W R Macon, L A Erickson, K L Grogg, P J Kurtin and A Dogan
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.320
Stem cell factor and high-dose twice daily filgrastim is an effective strategy for peripheral blood stem cell mobilization in patients with indolent lymphoproliferative disorders previously treated with fludarabine: results of a Phase II study with an historical comparator
K E Herbert, S Morgan, H M Prince, D A Westerman, M M Wolf, D A Carney, K Yuen, J di Iulio and J F Seymour
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.302
Early clearance of peripheral blasts measured by flow cytometry during the first week of AML induction therapy as a new independent prognostic factor: a GOELAMS study
F Lacombe, C Arnoulet, M Maynadié, E Lippert, I Luquet, A Pigneux, N Vey, O Casasnovas, F Witz and M C Béné
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.296
C/EBP or C/EBP oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-
B p50 bound to the bcl-2 and FLIP gene promoters
I Paz-Priel, A K Ghosal, J Kowalski and A D Friedman
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.297
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
K Schmiegelow, E Forestier, J Kristinsson, S Söderhäll, K Vettenranta, R Weinshilboum and F Wesenberg On behalf of the Nordic Society of Paediatric Haematology and Oncology (NOPHO)
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.316
Detection and molecular monitoring of FIP1L1-PDGFRA-positive disease by analysis of patient-specific genomic DNA fusion junctions
J Score, C Walz, J V Jovanovic, A V Jones, K Waghorn, C Hidalgo-Curtis, F Lin, D Grimwade, F Grand, A Reiter and N C P Cross
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.309
Allogeneic bone marrow transplantation and donor lymphocyte infusion in a mouse model of irradiation-induced myelodysplastic/myeloproliferation syndrome (MD/MPS): evidence for a graft-versus-MD/MPS effect
B Sprangers, B Van Wijmeersch, A Luyckx, X Sagaert, L De Somer, O Rutgeerts, C Lenaerts, W Landuyt, N Boeckx, B Dubois, C De Wolf-Peeters, M Waer and A D Billiau
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.298
The molecular anatomy of the FIP1L1-PDGFRA fusion gene
C Walz, J Score, J Mix, D Cilloni, C Roche-Lestienne, R-F Yeh, J L Wiemels, E Ottaviani, P Erben, A Hochhaus, M Baccarani, D Grimwade, C Preudhomme, J Apperley, G Martinelli, G Saglio, N C P Cross and A Reiter on behalf of the European LeukemiaNet
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.310
The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia
B Wegiel, J Ekberg, K M Talasila, S Jalili and J L Persson
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.300
Letters to the Editor
Downregulated expression of genes mapping on chromosome 9 in chronic myeloid leukemia cases bearing genomic deletions on der(9)
F Albano, L Anelli, A Zagaria, A Pannunzio, V Liso, M Rocchi and G Specchia
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.311
Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia
W Deenik, H B Beverloo, S C P A M van der Poel-van de Luytgaarde, M M Wattel, J W J van Esser, P J M Valk and J J Cornelissen
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.318
Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients
N Karas-Kuzelicki, J Jazbec, M Milek and I Mlinaric-Rascan
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.317
Early events of B-cell receptor signaling are not essential for the proliferation and viability of AIDS-related lymphoma
P Lu, C Yang, I Guasparri, W Harrington, Y L Wang and E Cesarman the AIDS Malignancy Clinical Trials Consortium
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.304
Hematopoietic colony-stimulating factor priming does not influence survival in acute myeloid leukemia: a meta-analysis of randomized trials
L Sung, S M H Alibhai, J Beyene, A Gamis, R Almeida, S Smith and R Aplenc
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.305
Gene expression profile of slowly responding subclones might represent different profiles already at diagnosis and might be used for prediction of outcome
V de Haas, R Dee, G Cheroutre, H van den Berg and C E van der Schoot
Leukemia advance online publication, November 6, 2008; doi:10.1038/leu.2008.315
October 30 2008
Spotlight Review
Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma
R A Kyle and S V Rajkumar
Leukemia advance online publication, October 30, 2008; doi:10.1038/leu.2008.291
Original Article
Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1
A Chase, B Schultheis, S Kreil, J Baxter, C Hidalgo-Curtis, A Jones, L Zhang, F H Grand, J V Melo and N C P Cross
Leukemia advance online publication, October 30, 2008; doi:10.1038/leu.2008.295
Letter to the Editor
Simultaneous study of five candidate target antigens (CD20, CD22, CD33, CD52, HER2) for antibody-based immunotherapy in B-ALL: a monocentric study of 44 cases
P Chevallier, N Robillard, G Houille, S Ayari, T Guillaume, J Delaunay, J-L Harousseau, H Avet-Loiseau, M Mohty and R Garand
Leukemia advance online publication, October 30, 2008; doi:10.1038/leu.2008.303
October 23 2008
Original Article
Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species
E Ortiz-Sánchez, T R Daniels, G Helguera, O Martinez-Maza, B Bonavida, and M L Penichet
Leukemia advance online publication, October 23, 2008; doi:10.1038/leu.2008.270
Letters to the Editor
Dysgranulopoiesis is an independent adverse prognostic factor in chronic myeloid disorders with an isolated interstitial deletion of chromosome 5q
D Chen, J D Hoyer, R P Ketterling, A Tefferi, D P Steensma, S G Holtan, R Santana-Davila, L F Porrata, G W Dewald and C A Hanson
Leukemia advance online publication, October 23, 2008; doi:10.1038/leu.2008.279
Another pedigree with familial acute myeloid leukemia and germline CEBPA mutation
A Renneville, V Mialou, N Philippe, S Kagialis-Girard, V Biggio, M-T Zabot, X Thomas, Y Bertrand and C Preudhomme
Leukemia advance online publication, October 23, 2008; doi:10.1038/leu.2008.294
October 16 2008
Review
Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge
E G Boerma, R Siebert, P M Kluin and M Baudis
Leukemia advance online publication, October 16, 2008; doi:10.1038/leu.2008.281
Original Articles
Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia
C Graux, M Stevens-Kroef, M Lafage, N Dastugue, C J Harrison, F Mugneret, K Bahloula, S Struski, M J Grégoire, N Nadal, E Lippert, S Taviaux, A Simons, R P Kuiper, A V Moorman, K Barber, A Bosly, L Michaux, P Vandenberghe, I Lahortiga, K De Keersmaecker, I Wlodarska, J Cools, A Hagemeijer and H A Poirel on behalf of the GFCH (Groupe Francophone de Cytogénétique Hématologique) and the BCGHO (Belgian Cytogenetic Group for Hematology and Oncology)
Leukemia advance online publication, October 16, 2008; doi:10.1038/leu.2008.278
Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15d
12,14,PGJ2
R E Hayden, G Pratt, N J Davies, F L Khanim, J Birtwistle, J Delgado, C Pearce, T Sant, M T Drayson and C M Bunce
Leukemia advance online publication, October 16, 2008; doi:10.1038/leu.2008.283
Clinical consequences of hyperglycemia during remission induction therapy for pediatric acute lymphoblastic leukemia
J R Roberson, H L Spraker, J Shelso, Y Zhou, H Inaba, M L Metzger, J E Rubnitz, R C Ribeiro, J T Sandlund, S Jeha, C-H Pui and S C Howard
Leukemia advance online publication, October 16, 2008; doi:10.1038/leu.2008.289
Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
D Schotte, J C K Chau, G Sylvester, G Liu, C Chen, V H J van der Velden, M J C Broekhuis, T C J M Peters, R Pieters and M L den Boer
Leukemia advance online publication, October 16, 2008; doi:10.1038/leu.2008.286
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway
V Ullmannova-Benson, M Guan, X Zhou, V Tripathi, X-Y Yang, D B Zimonjic and N C Popescu
Leukemia advance online publication, October 16, 2008; doi:10.1038/leu.2008.285
October 9 2008
Spotlight Review
Bone marrow microenvironment and the identification of new targets for myeloma therapy
K Podar, D Chauhan and K C Anderson
Leukemia advance online publication, October 9, 2008; doi:10.1038/leu.2008.259
Original Articles
The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
F Dicker, H Herholz, S Schnittger, A Nakao, N Patten, L Wu, W Kern, T Haferlach and C Haferlach
Leukemia advance online publication, October 9, 2008; doi:10.1038/leu.2008.274
Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis
T Lwin, L A Crespo, A Wu, S Dessureault, H B Shu, L C Moscinski, E Sotomayor, W S Dalton and J Tao
Leukemia advance online publication, October 9, 2008; doi:10.1038/leu.2008.266
Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage
B da Costa Reis Monte-Mór, I Plo, A F da Cunha, G G L Costa, D M de Albuquerque, A Jedidi, J-L Villeval, S Badaoui, I Lorand-Metze, K B B Pagnano, S T O Saad, W Vainchenker and F F Costa
Leukemia advance online publication, October 9, 2008; doi:10.1038/leu.2008.275