ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
June 25 2009 |
June 18 2009 |
June 11 2009 |
June 4 2009 |
May 28 2009 |
May 21 2009 |
May 14 2009 |
May 7 2009 |
April 30 2009 |
April 23 2009 |
April 16 2009 |
April 9 2009 |
April 2 2009 |
March 26 2009 |
March 19 2009 |
March 12 2009 |
March 5 2009 |
February 26 2009 |
February 19 2009 |
February 12 2009 |
February 5 2009 |
January 22 2009 |
January 15 2009
July 9 2009
Spotlight Review
Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis
O Landgren and B M Weiss
Leukemia advance online publication, July 9, 2009; doi:10.1038/leu.2009.134
Original Articles
Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients
S Colucci, G Brunetti, G Mori, A Oranger, M Centonze, C Mori, F P Cantatore, R Tamma, R Rizzi, V Liso, A Zallone and M Grano
Leukemia advance online publication, July 9, 2009; doi:10.1038/leu.2009.136
PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study
J Familiades, M Bousquet, M Lafage-Pochitaloff, M-C Béné, K Beldjord, J De Vos, N Dastugue, E Coyaud, S Struski, C Quelen, N Prade-Houdellier, S Dobbelstein, J-M Cayuela, J Soulier, N Grardel, C Preudhomme, H Cavé, O Blanchet, V Lhéritier, A Delannoy, Y Chalandon, N Ifrah, A Pigneux, P Brousset, E A Macintyre, F Huguet, H Dombret, C Broccardo and É Delabesse
Leukemia advance online publication, July 9, 2009; doi:10.1038/leu.2009.135
Array-based DNA methylation profiling in follicular lymphoma
C O'Riain, D M O'Shea, Y Yang, R Le Dieu, J G Gribben, K Summers, J Yeboah-Afari, L Bhaw-Rosun, C Fleischmann, C A Mein, T Crook, P Smith, G Kelly, A Rosenwald, G Ott, E Campo, L M Rimsza, E B Smeland, W C Chan, N Johnson, R D Gascoyne, S Reimer, R M Braziel, G W Wright, L M Staudt, T A Lister and J Fitzgibbon
Leukemia advance online publication, July 9, 2009; doi:10.1038/leu.2009.114
Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1
J-M Terme, V Mocquet, A-S Kuhlmann, L Zane, F Mortreux, E Wattel, M Duc Dodon and P Jalinot
Leukemia advance online publication, July 9, 2009; doi:10.1038/leu.2009.131
Letter to the Editor
Increased expression of macrophage inflammatory protein-1
on trephine biopsies correlates with extensive bone disease, increased angiogenesis and advanced stage in newly diagnosed patients with multiple myeloma
M Roussou, A Tasidou, M A Dimopoulos, E Kastritis, M Migkou, D Christoulas, M Gavriatopoulou, F Zagouri, C Matsouka, D Anagnostou and E Terpos
Leukemia advance online publication, July 9, 2009; doi:10.1038/leu.2009.130
June 25 2009
Original Articles
Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
P Gasperini and G Tosato
Leukemia advance online publication, June 25, 2009; doi:10.1038/leu.2009.117
International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100)
S Giralt, E A Stadtmauer, J L Harousseau, A Palumbo, W Bensinger, R L Comenzo, S Kumar, N C Munshi, A Dispenzieri, R Kyle, G Merlini, J San Miguel, H Ludwig, R Hajek, S Jagannath, J Blade, S Lonial, M A Dimopoulos, H Einsele, B Barlogie, K C Anderson, M Gertz, M Attal, P Tosi, P Sonneveld, M Boccadoro, G Morgan, O Sezer, M V Mateos, M Cavo, D Joshua, I Turesson, W Chen, K Shimizu, R Powles, P G Richardson, R Niesvizky, S V Rajkumar and B G M Durie on behalf of the IMWG
Leukemia advance online publication, June 25, 2009; doi:10.1038/leu.2009.127
June 18 2009
Letter to the Editor
miR-34b/miR-34c: a regulator of TCL1 expression in 11q- chronic lymphocytic leukaemia?
B Cardinaud, C Moreilhon, B Marcet, K Robbe-Sermesant, K LeBrigand, B Mari, V Eclache, F Cymbalista, S Raynaud and P Barbry
Leukemia advance online publication, June 18, 2009; doi:10.1038/leu.2009.125
June 11 2009
Review
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications
B Falini, N Bolli, A Liso, M P Martelli, R Mannucci, S Pileri and I Nicoletti
Leukemia advance online publication, June 11, 2009; doi:10.1038/leu.2009.124
Original Article
Heritable T-cell malignancy models established in a zebrafish phenotypic screen
J K Frazer, N D Meeker, L Rudner, D F Bradley, A C H Smith, B Demarest, D Joshi, E E Locke, S A Hutchinson, S Tripp, S L Perkins and N S Trede
Leukemia advance online publication, June 11, 2009; doi:10.1038/leu.2009.116
Letter to the Editor
Acquisition of a multidrug-resistant phenotype with a proteasome inhibitor in multiple myeloma
D Gutman, A A Morales and L H Boise
Leukemia advance online publication, June 11, 2009; doi:10.1038/leu.2009.123
June 4 2009
Review
International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation
A Palumbo, O Sezer, R Kyle, J S Miguel, R Z Orlowski, P Moreau, R Niesvizky, G Morgan, R Comenzo, P Sonneveld, S Kumar, R Hajek, S Giralt, S Bringhen, K C Anderson, P G Richardson, M Cavo, F Davies, J Bladé, H Einsele, M A Dimopoulos, A Spencer, A Dispenzieri, T Reiman, K Shimizu, J H Lee, M Attal, M Boccadoro, M Mateos, W Chen, H Ludwig, D Joshua, J Chim, V Hungria, I Turesson, B G M Durie and S Lonial on behalf of the IMWG
Leukemia advance online publication, June 4, 2009; doi:10.1038/leu.2009.122
Original Articles
The effects of JNJ-26481585, a novel hydroxamate-based histone deacetylase inhibitor, on the development of multiple myeloma in the 5T2MM and 5T33MM murine models
S Deleu, M Lemaire, J Arts, E Menu, E Van Valckenborgh, P King, I Vande Broek, H De Raeve, B Van Camp, P Croucher and K Vanderkerken
Leukemia advance online publication, June 4, 2009; doi:10.1038/leu.2009.121
Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism
P Gelebart, Z Zak, M Anand, J Dien-Bard, H M Amin and R Lai
Leukemia advance online publication, June 4, 2009; doi:10.1038/leu.2009.100
Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma
H Schwindt, I Vater, M Kreuz, M Montesinos-Rongen, A Brunn, J Richter, S Gesk, O Ammerpohl, O D Wiestler, D Hasenclever, M Deckert and R Siebert
Leukemia advance online publication, June 4, 2009; doi:10.1038/leu.2009.120
Letter to the Editor
Src family kinase gene targets during myeloid differentiation: identification of the EGR-1 gene as a direct target
J E Jones, L Wang, P L Kropf, R Duan and D E Johnson
Leukemia advance online publication, June 4, 2009; doi:10.1038/leu.2009.118
May 28 2009
Review
Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia
F J Giles, M O'Dwyer and R Swords
Leukemia advance online publication, May 28, 2009; doi:10.1038/leu.2009.111
Original Articles
Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China
Y Cheng, Y Wang, H Wang, Z Chen, J Lou, H Xu, H Wang, W Qian, H Meng, M Lin and J Jin
Leukemia advance online publication, May 28, 2009; doi:10.1038/leu.2009.107
Identification of MNDA as a new marker for nodal marginal zone lymphoma
G Kanellis, G Roncador, A Arribas, M Mollejo, S Montes-Moreno, L Maestre, Y Campos-Martin, J L Ríos Gonzalez, J L Martinez-Torrecuadrada, L Sanchez-Verde, R Pajares, J C Cigudosa, M C Martin and M A Piris
Leukemia advance online publication, May 28, 2009; doi:10.1038/leu.2009.108
May 21 2009
Original Articles
Interferon-
-induced neuronal differentiation of human umbilical cord blood-derived progenitors
H Arien-Zakay, S Lecht, M M Bercu, N Amariglio, G Rechavi, H Galski, P Lazarovici and A Nagler
Leukemia advance online publication, May 21, 2009; doi:10.1038/leu.2009.106
Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells
B Z Carter, D H Mak, R Woessner, S Gross, W D Schober, Z Estrov, H Kantarjian and M Andreeff
Leukemia advance online publication, May 21, 2009; doi:10.1038/leu.2009.101
AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2
B Jiao, C-F Wu, Y Liang, H-M Chen, S-M Xiong, B Chen, J-Y Shi, Y-Y Wang, J-H Wang, Y Chen, J-M Li, L-J Gu, J-Y Tang, Z-X Shen, B-W Gu, W-L Zhao, Z Chen and S-J Chen
Leukemia advance online publication, May 21, 2009; doi:10.1038/leu.2009.104
Letters to the Editor
Erythroid/B-cell biphenotypic acute leukemia first case report
J C Lee, S Yang, Y Zou and L Joseph
Leukemia advance online publication, May 21, 2009; doi:10.1038/leu.2009.105
SNP analyses in cytarabine metabolizing enzymes in AML patients and their impact on treatment response and patient survival: identification of CDA SNP C-451T as an independent prognostic parameter for survival
U Mahlknecht, C-L Dransfeld, N Bulut, M Kramer, C Thiede, G Ehninger and M Schaich
Leukemia advance online publication, May 21, 2009; doi:10.1038/leu.2009.113
The 1170 A–P single-nucleotide polymorphism (SNP) in the Her-2/neu protein (HER2) as a minor histocompatibility antigen (mHag)
L Wenandy, T Kollgaard, A Letsch, R S Andersen, D Stather, T Seremet, I M Svane, L Vindeløv, M H Andersen and P thor Straten
Leukemia advance online publication, May 21, 2009; doi:10.1038/leu.2009.112
May 14 2009
Original Articles
STAT6 and STAT1 are essential antagonistic regulators of cell survival in classical Hodgkin lymphoma cell line
D Baus, F Nonnenmacher, S Jankowski, C Döring, C Bräutigam, M Frank, M-L Hansmann and E Pfitzner
Leukemia advance online publication, May 14, 2009; doi:10.1038/leu.2009.103
Reduced-intensity conditioning allogeneic stem cell transplantation is a potential therapeutic approach for adults with high-risk acute lymphoblastic leukemia in remission: results of a prospective phase 2 study
B-S Cho, S Lee, Y-J Kim, N-G Chung, K-S Eom, H-J Kim, C-K Min, S-G Cho, D-W Kim, J-W Lee, W-S Min and C-C Kim
Leukemia advance online publication, May 14, 2009; doi:10.1038/leu.2009.102
Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
K Giannopoulos, A Dmoszynska, M Kowal, E W
sik-Szczepanek, A Bojarska-Junak, J Rolinski, H Döhner, S Stilgenbauer and L Bullinger
Leukemia advance online publication, May 14, 2009; doi:10.1038/leu.2009.98
Monoclonal antibodies against IREM-1: potential for targeted therapy of AML
W Korver, X Zhao, S Singh, C Pardoux, J Zhao, M L Guzman, S Sen, S Yonkovich, S Liu, X Zhan, N Tomasevic, C Zhou, D Gros, C T Jordan, J Gotlib, E D Hsi and A Abo
Leukemia advance online publication, May 14, 2009; doi:10.1038/leu.2009.99
Letters to the Editor
The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera
D Olcaydu, R C Skoda, R Looser, S Li, M Cazzola, D Pietra, F Passamonti, E Lippert, S Carillo, F Girodon, A Vannucchi, N S Reading, J T Prchal, C Ay, I Pabinger, H Gisslinger and R Kralovics
Leukemia advance online publication, May 14, 2009; doi:10.1038/leu.2009.110
Recombinant interferon alpha (rIFN-2b) may retard progression of early primary myelofibrosis
R T Silver and K Vandris
Leukemia advance online publication, May 14, 2009; doi:10.1038/leu.2009.90
May 7 2009
Review
International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma
M Dimopoulos, E Terpos, R L Comenzo, P Tosi, M Beksac, O Sezer, D Siegel, H Lokhorst, S Kumar, S V Rajkumar, R Niesvizky, L A Moulopoulos and B G M Durie On behalf of the IMWG
Leukemia advance online publication, May 7, 2009; doi:10.1038/leu.2009.89
Original Articles
STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma
P Coppo, V Gouilleux-Gruart, Y Huang, H Bouhlal, H Bouamar, S Bouchet, C Perrot, V Vieillard, P Dartigues, P Gaulard, F Agbalika, L Douay, K Lassoued and N-C Gorin
Leukemia advance online publication, May 7, 2009; doi:10.1038/leu.2009.91
A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies
T Ikezoe, J Yang, C Nishioka, Y Takezaki, T Tasaka, K Togitani, H P Koeffler and A Yokoyama
Leukemia advance online publication, May 7, 2009; doi:10.1038/leu.2009.94
Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein–Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells
B Renouf, É Hollville, A Pujals, C Tétaud, J Garibal and J Wiels
Leukemia advance online publication, May 7, 2009; doi:10.1038/leu.2009.92
Letters to the Editor
Cytoplasmic mutated nucleophosmin (NPM1) in blast crisis of chronic myeloid leukaemia
P P Piccaluga, E Sabattini, F Bacci, C Agostinelli, S Righi, F Salmi, N Testoni, S Paolini, F Castagnetti, G Martinelli, B Falini and S A Pileri
Leukemia advance online publication, May 7, 2009; doi:10.1038/leu.2009.95
Efficacy of dasatinib in conjunction with -interferon for the treatment of imatinib-resistant and dasatinib-resistant Ph+ acute lymphoblastic leukemia
G Visani, P Piccaluga, M Malagola and A Isidori
Leukemia advance online publication, May 7, 2009; doi:10.1038/leu.2009.96
April 30 2009
Review
Pharmacokinetic/pharmacodynamic correlation and blood-level testing in imatinib therapy for chronic myeloid leukemia
J E Cortes, M J Egorin, F Guilhot, M Molimard and F-X Mahon
Leukemia advance online publication, April 30, 2009; doi:10.1038/leu.2009.88
Original Article
MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM
A A Rambal, Z L G Panaguiton, L Kramer, S Grant and H Harada
Leukemia advance online publication, April 30, 2009; doi:10.1038/leu.2009.80
April 23 2009
Original Articles
Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics
S Heinrichs, R V Kulkarni, C E Bueso-Ramos, R L Levine, M L Loh, C Li, D Neuberg, S M Kornblau, J-P Issa, D G Gilliland, G Garcia-Manero, H M Kantarjian, E H Estey and A T Look
Leukemia advance online publication, April 23, 2009; doi:10.1038/leu.2009.82
Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia
A Valencia, J Román-Gómez, J Cervera, E Such, E Barragán, P Bolufer, F Moscardó, G F Sanz and M A Sanz
Leukemia advance online publication, April 23, 2009; doi:10.1038/leu.2009.86
Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms
J Wang, T Ishii, W Zhang, S Sozer, Y Dai, J Mascarenhas, V Najfeld, Z J Zhao, R Hoffman, N Wisch and M Xu
Leukemia advance online publication, April 23, 2009; doi:10.1038/leu.2009.85
Letter to the Editor
A novel pedigree with heterozygous germline RUNX1 mutation causing familial MDS-related AML: can these families serve as a multistep model for leukemic transformation?
T Ripperger, D Steinemann, G Göhring, J Finke, C M Niemeyer, B Strahm and B Schlegelberger
Leukemia advance online publication, April 23, 2009; doi:10.1038/leu.2009.87
April 16 2009
Original Articles
Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells
M Bebawy, V Combes, E Lee, R Jaiswal, J Gong, A Bonhoure and G E R Grau
Leukemia advance online publication, April 16, 2009; doi:10.1038/leu.2009.76
The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL
A A Mian, M Schüll, Z Zhao, C Oancea, A Hundertmark, T Beissert, O G Ottmann and M Ruthardt
Leukemia advance online publication, April 16, 2009; doi:10.1038/leu.2009.69
Ascorbic acid inhibits antitumor activity of bortezomib in vivo
G Perrone, T Hideshima, H Ikeda, Y Okawa, E Calabrese, G Gorgun, L Santo, D Cirstea, N Raje, D Chauhan, M Baccarani, M Cavo and K C Anderson
Leukemia advance online publication, April 16, 2009; doi:10.1038/leu.2009.83
Enhanced expression of FHL2 leads to abnormal myelopoiesis in vivo
Z Qian, L Mao, A A Fernald, H Yu, R Luo, Y Jiang, J Anastasi, P J Valk, R Delwel and M M Le Beau
Leukemia advance online publication, April 16, 2009; doi:10.1038/leu.2009.78
CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells
A Takeshita, N Yamakage, K Shinjo, T Ono, I Hirano, S Nakamura, K Shigeno, T Tobita, M Maekawa, H Kiyoi, T Naoe, K Ohnishi, Y Sugimoto and R Ohno
Leukemia advance online publication, April 16, 2009; doi:10.1038/leu.2009.77
Letters to the Editor
Flow cytometric identification of acute myeloid leukemia with limited differentiation and NPM1 type A mutation: a new biologically defined entity
W Kern, C Haferlach, U Bacher, T Haferlach and S Schnittger
Leukemia advance online publication, April 16, 2009; doi:10.1038/leu.2009.84
LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome
G Soler, S Nusbaum, B Varet, E A Macintyre, M Vekemans, S P Romana and I Radford-Weiss
Leukemia advance online publication, April 16, 2009; doi:10.1038/leu.2009.79
April 9 2009
Concise Review
NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia
P J Real and A A Ferrando
Leukemia advance online publication, April 9, 2009; doi:10.1038/leu.2009.75
Original Articles
Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors
M Garayoa, J L Garcia, C Santamaria, A Garcia-Gomez, J F Blanco, A Pandiella, J M Hernández, F M Sanchez-Guijo, M-C del Cañizo, N C Gutiérrez and J F San Miguel
Leukemia advance online publication, April 9, 2009; doi:10.1038/leu.2009.65
BCR–ABL promotes neutrophil differentiation in the chronic phase of chronic myeloid leukemia by downregulating c-Jun expression
S Kobayashi, F Kimura, T Ikeda, Y Osawa, H Torikai, A Kobayashi, K Sato and K Motoyoshi
Leukemia advance online publication, April 9, 2009; doi:10.1038/leu.2009.74
WT1 peptide-specific T cells generated from peripheral blood of healthy donors: possible implications for adoptive immunotherapy after allogeneic stem cell transplantation
G Weber, J Karbach, S Kuçi, H Kreyenberg, A Willasch, E Koscielniak, T Tonn, T Klingebiel, W S Wels, E Jäger and P Bader
Leukemia advance online publication, April 9, 2009; doi:10.1038/leu.2009.70
Defective engraftment of C3aR-/- hematopoietic stem progenitor cells shows a novel role of the C3a–C3aR axis in bone marrow homing
M Wysoczynski, R Reca, H Lee, W Wu, J Ratajczak and M Z Ratajczak
Leukemia advance online publication, April 9, 2009; doi:10.1038/leu.2009.73
Letter to the Editor
Immunoglobulin and T-cell receptor gene rearrangements as PCR-based targets are stable markers for monitoring minimal residual disease in acute lymphoblastic leukemia after stem cell transplantation
H Kreyenberg, C Eckert, Y Yarkin, M Reising, A Willasch, R Handgretinger, B Kremens, A von Stackelberg, G Henze, T Klingebiel and P Bader
Leukemia advance online publication, April 9, 2009; doi:10.1038/leu.2009.72
April 2 2009
Original Articles
Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells
P Gamas, S Marchetti, A Puissant, S Grosso, A Jacquel, P Colosetti, J-M Pasquet, F-X Mahon, J-P Cassuto and P Auberger
Leukemia advance online publication, April 2, 2009; doi:10.1038/leu.2009.60
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
A Larson Gedman, Q Chen, S Kugel Desmoulin, Y Ge, K LaFiura, C L Haska, C Cherian, M Devidas, S B Linda, J W Taub and L H Matherly
Leukemia advance online publication, April 2, 2009; doi:10.1038/leu.2009.64
The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains
J A Marteijn, L T van der Meer, J J Smit, S M Noordermeer, W Wissink, P Jansen, H G Swarts, R G Hibbert, T de Witte, T K Sixma, J H Jansen and B A van der Reijden
Leukemia advance online publication, April 2, 2009; doi:10.1038/leu.2009.57
Letters to the Editor
Reduced folate carrier and methylenetetrahydrofolate reductase gene polymorphisms: associations with clinical outcome in childhood acute lymphoblastic leukemia
L J Ashton, A J Gifford, E Kwan, A Lingwood, D T T Lau, G M Marshall, M Haber and M D Norris
Leukemia advance online publication, April 2, 2009; doi:10.1038/leu.2009.67
Detection of p53 dysfunction in chronic lymphocytic leukaemia cells through multiplex quantification of p53 target gene induction
R Mous, A Jaspers, D M P Luijks, C H M Mellink, M H J van Oers, A P Kater and E Eldering
Leukemia advance online publication, April 2, 2009; doi:10.1038/leu.2009.71
Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation
J W Tyner, M L Rutenberg-Schoenberg, H Erickson, S G Willis, T O'Hare, M W Deininger, B J Druker and M M Loriaux
Leukemia advance online publication, April 2, 2009; doi:10.1038/leu.2009.66
March 26 2009
Spotlight Reviews
Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer
B L Ebert
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.53
Chromatin maps, histone modifications and leukemia
T Neff and S A Armstrong
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.40
Original Articles
The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation
M Abraham, K Beider, H Wald, I D Weiss, D Zipori, E Galun, A Nagler, O Eizenberg and A Peled
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.56
Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice
Y Chen, Y Hu, S Michaels, D Segal, D Brown and S Li
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.52
Is the international staging system superior to the Durie–Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant
P N Hari, M-J Zhang, V Roy, W S Pérez, A Bashey, L B To, G Elfenbein, C O Freytes, R P Gale, J Gibson, R A Kyle, H M Lazarus, P L McCarthy, G A Milone, S Pavlovsky, D E Reece, G Schiller, J Vela-Ojeda, D Weisdorf and D Vesole
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.61
Standardization of WT1 mRNA quantitation for minimal residual disease monitoring in childhood AML and implications of WT1 gene mutations: a European multicenter study
A M Willasch, B Gruhn, T Coliva, M Kalinova, G Schneider, H Kreyenberg, D Steinbach, G Weber, I H I M Hollink, C M Zwaan, A Biondi, V H J van der Velden, D Reinhardt, G Cazzaniga, P Bader and J Trka on behalf of the European Study Group on WT1 Expression in Childhood AML. Frankfurt, Jena (Germany), Monza (Italy), Prague (Czech Republic)
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.51
PML–RAR initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors
S Wojiski, F C Guibal, T Kindler, B H Lee, J L Jesneck, A Fabian, D G Tenen and D G Gilliland
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.63
Letter to the Editor
Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia
L Yánez, A Bermúdez, C Richard, E Bureo and A Iriondo
Leukemia advance online publication, March 26, 2009; doi:10.1038/leu.2009.58
March 19 2009
Original Articles
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy
S Mustjoki, M Ekblom, T P Arstila, I Dybedal, P K Epling-Burnette, F Guilhot, H Hjorth-Hansen, M Höglund, P Kovanen, T Laurinolli, J Liesveld, R Paquette, J Pinilla-Ibarz, A Rauhala, N Shah, B Simonsson, M Sinisalo, J L Steegmann, L Stenke and K Porkka
Leukemia advance online publication, March 19, 2009; doi:10.1038/leu.2009.46
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway
R Naughton, C Quiney, S D Turner and T G Cotter
Leukemia advance online publication, March 19, 2009; doi:10.1038/leu.2009.49
CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients
A Pardanani, T Lasho, G Smith, C J Burns, E Fantino and A Tefferi
Leukemia advance online publication, March 19, 2009; doi:10.1038/leu.2009.50
Letter to the Editor
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
A Tefferi, K-H Lim, O Abdel-Wahab, T L Lasho, J Patel, M M Patnaik, C A Hanson, A Pardanani, D G Gilliland and R L Levine
Leukemia advance online publication, March 19, 2009; doi:10.1038/leu.2009.59
March 12 2009
Original Articles
Continuous Fli-1 expression plays an essential role in the proliferation and survival of F-MuLV-induced erythroleukemia and human erythroleukemia
J-W Cui, L M Vecchiarelli-Federico, Y-J Li, G-J Wang and Y Ben-David
Leukemia advance online publication, March 12, 2009; doi:10.1038/leu.2009.20
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1
S Jeha, D Pei, S C Raimondi, M Onciu, D Campana, C Cheng, J T Sandlund, R C Ribeiro, J E Rubnitz, S C Howard, J R Downing, W E Evans, M V Relling and C-H Pui
Leukemia advance online publication, March 12, 2009; doi:10.1038/leu.2009.42
RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation
M-C Kuo, D-C Liang, C-F Huang, Y-S Shih, J-H Wu, T-L Lin and L-Y Shih
Leukemia advance online publication, March 12, 2009; doi:10.1038/leu.2009.48
The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis
Q-L Zhang, L Wang, Y-W Zhang, X-X Jiang, F Yang, W-L Wu, A Janin, Z Chen, Z-X Shen, S-J Chen and W-L Zhao
Leukemia advance online publication, March 12, 2009; doi:10.1038/leu.2009.41
Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome
J X Zou, D E Rollison, D Boulware, D-T Chen, E M Sloand, L V Pfannes, J J Goronzy, F Bai, J S Painter, S Wei, D Cosgrove, A F List and P K Epling-Burnette
Leukemia advance online publication, March 12, 2009; doi:10.1038/leu.2009.14
March 5 2009
Spotlight Review
Genomic approaches to small molecule discovery
K Stegmaier
Leukemia advance online publication, March 5, 2009; doi:10.1038/leu.2009.29
Original Articles
New insights to the MLL recombinome of acute leukemias
C Meyer, E Kowarz, J Hofmann, A Renneville, J Zuna, J Trka, R Ben Abdelali, E Macintyre, E De Braekeleer, M De Braekeleer, E Delabesse, M P de Oliveira, H Cavé, E Clappier, J J M van Dongen, B V Balgobind, M M van den Heuvel-Eibrink, H B Beverloo, R Panzer-Grümayer, A Teigler-Schlegel, J Harbott, E Kjeldsen, S Schnittger, U Koehl, B Gruhn, O Heidenreich, L C Chan, S F Yip, M Krzywinski, C Eckert, A Möricke, M Schrappe, C N Alonso, B W Schäfer, J Krauter, D A Lee, U zur Stadt, G Te Kronnie, R Sutton, S Izraeli, L Trakhtenbrot, L Lo Nigro, G Tsaur, L Fechina, T Szczepanski, S Strehl, D Ilencikova, M Molkentin, T Burmeister, T Dingermann, T Klingebiel and R Marschalek
Leukemia advance online publication, March 5, 2009; doi:10.1038/leu.2009.33
A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability
B ten Cate, E Bremer, M de Bruyn, T Bijma, D Samplonius, M Schwemmlein, G Huls, G Fey and W Helfrich
Leukemia advance online publication, March 5, 2009; doi:10.1038/leu.2009.34
February 26 2009
Spotlight Review
Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions
C G Mullighan and J R Downing
Leukemia advance online publication, February 26, 2009; doi:10.1038/leu.2009.18
Original Articles
Phase II study of rabbit anti-thymocyte globulin, cyclosporine and granulocyte colony-stimulating factor in patients with aplastic anemia and myelodysplastic syndrome
R Garg, S Faderl, G Garcia-Manero, J Cortes, C Koller, X Huang, S York, S Pierce, M Brandt, M Beran, G Borthakur, H Kantarjian and F Ravandi
Leukemia advance online publication, February 26, 2009; doi:10.1038/leu.2009.28
Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial
J E Rubnitz, K R Crews, S Pounds, S Yang, D Campana, V V Gandhi, S C Raimondi, J R Downing, B I Razzouk, C-H Pui and R C Ribeiro
Leukemia advance online publication, February 26, 2009; doi:10.1038/leu.2009.30
February 19 2009
Original Articles
Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients
W-C Chou, C-Y Chen, H-A Hou, L-I Lin, J-L Tang, M Yao, W Tsay, B-S Ko, S-J Wu, S-Y Huang, S-C Hsu, Y-C Chen, Y-N Huang, M-H Tseng, C-F Huang and H-F Tien
Leukemia advance online publication, February 19, 2009; doi:10.1038/leu.2009.25
Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial
C B Reeder, D E Reece, V Kukreti, C Chen, S Trudel, J Hentz, B Noble, N A Pirooz, J E Spong, J G Piza, V H J Zepeda, J R Mikhael, J F Leis, P L Bergsagel, R Fonseca and A K Stewart
Leukemia advance online publication, February 19, 2009; doi:10.1038/leu.2009.26
Cyclin D1 as a universally expressed mantle cell lymphoma-associated tumor antigen for immunotherapy
M Wang, L Sun, J Qian, X Han, L Zhang, P Lin, Z Cai and Q Yi
Leukemia advance online publication, February 19, 2009; doi:10.1038/leu.2009.19
February 12 2009
Original Articles
GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines
A Furuhata, M Murakami, H Ito, S Gao, K Yoshida, S Sobue, R Kikuchi, T Iwasaki, A Takagi, T Kojima, M Suzuki, A Abe, T Naoe and T Murate
Leukemia advance online publication, February 12, 2009; doi:10.1038/leu.2009.13
Induction death and treatment-related mortality in first remission of children with acute lymphoblastic leukemia: a population-based analysis of the Austrian Berlin-Frankfurt-Münster study group
C Prucker, A Attarbaschi, C Peters, M N Dworzak, U Pötschger, C Urban, F-M Fink, B Meister, K Schmitt, O A Haas, H Gadner and G Mann on behalf of the Austrian Berlin-Frankfurt-Münster (BFM) Study Group
Leukemia advance online publication, February 12, 2009; doi:10.1038/leu.2009.12
Effects of activating NK cell receptor expression and NK cell reconstitution on the outcomes of unrelated donor hematopoietic cell transplantation for hematologic malignancies
B M Triplett, E M Horwitz, R Iyengar, V Turner, M S Holladay, K Gan, F G Behm and W Leung
Leukemia advance online publication, February 12, 2009; doi:10.1038/leu.2009.21
February 5 2009
Spotlight Review
Toward a systems biology approach to investigate cellular networks in normal and malignant B cells
K Basso
Leukemia advance online publication, February 5, 2009; doi:10.1038/leu.2009.4
January 22 2009
Spotlight Review
Genomic tools for dissecting oncogenic transcriptional networks in human leukemia
T Palomero and A A Ferrando
Leukemia advance online publication, January 22, 2009; doi:10.1038/leu.2008.394
