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LATEST: 2007 impact factor 9.954 from Journal Citation Reports, Thomson 2008
Featured article
p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
We describe a p53-regulated feed-forward loop comprising the transcription factor E2F1 and a family of paralogous miRNAs whose coordinate action regulate shared anti-proliferative target genes. We show that overexpression of representative microRNAs promotes proliferation and delays senescence, manifesting the detrimental phenotypic consequence of perturbations in this circuit.
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Research articles
p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
Ran Brosh, Reut Shalgi, Atar Liran, Gilad Landan, Katya Korotayev, Giang Huong Nguyen, Espen Enerly, Hilde Johnsen, Yosef Buganim, Hilla Solomon, Ido Goldstein, Shalom Madar, Naomi Goldfinger, Anne-Lise Børresen-Dale, Doron Ginsberg, Curtis C Harris, Yitzhak Pilpel, Moshe Oren & Varda Rotter
doi:10.1038/msb.2008.65
Published online: 25 November 2008
Model-guided design of ligand-regulated RNAi for programmable control of gene expression
Chase L Beisel, Travis S Bayer, Kevin G Hoff & Christina D Smolke
doi:10.1038/msb.2008.62
Published online: 28 October 2008
Finding multiple target optimal intervention in disease-related molecular network
Kun Yang, Hongjun Bai, Qi Ouyang, Luhua Lai & Chao Tang
doi:10.1038/msb.2008.60
Published online: 04 November 2008
Hepatitis C virus infection protein network
B de Chassey, V Navratil, L Tafforeau, M S Hiet, A Aublin-Gex, S Agaugué, G Meiffren, F Pradezynski, B F Faria, T Chantier, M Le Breton, J Pellet, N Davoust, P E Mangeot, A Chaboud, F Penin, Y Jacob, P O Vidalain, M Vidal, P André, C Rabourdin-Combe & V Lotteau
doi:10.1038/msb.2008.66
Published online: 04 November 2008
An integrated cell-free metabolic platform for protein production and synthetic biology
Michael C Jewett, Kara A Calhoun, Alexei Voloshin, Jessica J Wuu & James R Swartz
doi:10.1038/msb.2008.57
Published online: 14 October 2008
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes
Sandrine P Claus, Tsz M Tsang, Yulan Wang, Olivier Cloarec, Eleni Skordi, François-Pierre Martin, Serge Rezzi, Alastair Ross, Sunil Kochhar, Elaine Holmes & Jeremy K Nicholson
doi:10.1038/msb.2008.56
Published online: 14 October 2008
A quantitative comparison of sRNA-based and protein-based gene regulation
Pankaj Mehta, Sidhartha Goyal & Ned S Wingreen
doi:10.1038/msb.2008.58
Published online: 14 October 2008
Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation
Ophir Shalem, Orna Dahan, Michal Levo, Maria Rodriguez Martinez, Itay Furman, Eran Segal & Yitzhak Pilpel
doi:10.1038/msb.2008.59
Published online: 14 October 2008
A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves
Simona Digiuni, Swen Schellmann, Florian Geier, Bettina Greese, Martina Pesch, Katja Wester, Burcu Dartan, Valerie Mach, Bhylahalli Purushottam Srinivas, Jens Timmer, Christian Fleck & Martin Hulskamp
doi:10.1038/msb.2008.54
Published online: 02 September 2008
InnateDB: facilitating systems-level analyses of the mammalian innate immune response
David J Lynn, Geoffrey L Winsor, Calvin Chan, Nicolas Richard, Matthew R Laird, Aaron Barsky, Jennifer L Gardy, Fiona M Roche, Timothy H W Chan, Naisha Shah, Raymond Lo, Misbah Naseer, Jaimmie Que, Melissa Yau, Michael Acab, Dan Tulpan, Matthew D Whiteside, Avinash Chikatamarla, Bernadette Mah, Tamara Munzner, Karsten Hokamp, Robert E W Hancock & Fiona S L Brinkman
doi:10.1038/msb.2008.55
Published online: 02 September 2008
Reports
The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest
Gábor Balázsi, Allison P Heath, Lanbo Shi & Maria L Gennaro
doi:10.1038/msb.2008.63
Published online: 04 November 2008
Models from experiments: combinatorial drug perturbations of cancer cells
Sven Nelander, Weiqing Wang, Björn Nilsson, Qing-Bai She, Christine Pratilas, Neal Rosen, Peter Gennemark & Chris Sander
doi:10.1038/msb.2008.53
Published online: 02 September 2008
News & Views
'Junk' DNA meets the p53 network
Christine Blattner
doi:10.1038/msb.2008.68
Published online: 25 November 2008
Developmental regulatory bits
Eric D Siggia
doi:10.1038/msb.2008.64
Published online: 04 November 2008
Small hairpin RNA as a small molecule sensor
Yaakov Benenson
doi:10.1038/msb.2008.67
Published online: 28 October 2008
Reviews
Selected reaction monitoring for quantitative proteomics: a tutorial
Vinzenz Lange, Paola Picotti, Bruno Domon & Ruedi Aebersold
doi:10.1038/msb.2008.61
Published online: 14 October 2008
Perspectives
High-order combination effects and biological robustness
Joseph Lehár, Andrew Krueger, Grant Zimmermann & Alexis Borisy
doi:10.1038/msb.2008.51
Published online: 05 August 2008
Life Sciences and the web: a new era for collaboration
Jonathan A Sagotsky, Le Zhang, Zhihui Wang, Sean Martin & Thomas S Deisboeck
doi:10.1038/msb.2008.39
Published online: 01 July 2008
More systems biology from NPG & EMBO
A selection of relevant articles hosted by Nature Publishing Group are listed below. More articles can be found on the Systems biology Subject Area page.
Single-RNA counting reveals alternative modes of gene expression in yeast
