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LATEST: 2007 impact factor 9.954 from Journal Citation Reports, Thomson 2008
Featured article
A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves
De novo pattern formation of trichomes in Arabidopsis is modelled and experimentally tested at the level of competitive complex formation of trichome promoting and inhibiting factors. The relevance of three possible interaction scenarios is evaluated by a combination of overexpression experiments and modelling. This work demonstrates that the mutual interplay between theory and experiment can reveal a new level of understanding of how biochemical mechanisms drive biological patterning processes.
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- Network-based global inference of human disease genes
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Research articles
A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves
Simona Digiuni, Swen Schellmann, Florian Geier, Bettina Greese, Martina Pesch, Katja Wester, Burcu Dartan, Valerie Mach, Bhylahalli Purushottam Srinivas, Jens Timmer, Christian Fleck & Martin Hulskamp
doi:10.1038/msb.2008.54
Published online: 02 September 2008
InnateDB: facilitating systems-level analyses of the mammalian innate immune response
David J Lynn, Geoffrey L Winsor, Calvin Chan, Nicolas Richard, Matthew R Laird, Aaron Barsky, Jennifer L Gardy, Fiona M Roche, Timothy H W Chan, Naisha Shah, Raymond Lo, Misbah Naseer, Jaimmie Que, Melissa Yau, Michael Acab, Dan Tulpan, Matthew D Whiteside, Avinash Chikatamarla, Bernadette Mah, Tamara Munzner, Karsten Hokamp, Robert E W Hancock & Fiona S L Brinkman
doi:10.1038/msb.2008.55
Published online: 02 September 2008
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Oded Shaham, Ru Wei, Thomas J Wang, Catherine Ricciardi, Gregory D Lewis, Ramachandran S Vasan, Steven A Carr, Ravi Thadhani, Robert E Gerszten & Vamsi K Mootha
doi:10.1038/msb.2008.50
Published online: 05 August 2008
Constraints imposed by non-functional protein–protein interactions on gene expression and proteome size
Jingshan Zhang, Sergei Maslov & Eugene I Shakhnovich
doi:10.1038/msb.2008.48
Published online: 05 August 2008
Variable sizes of Escherichia coli chemoreceptor signaling teams
Robert G Endres, Olga Oleksiuk, Clinton H Hansen, Yigal Meir, Victor Sourjik & Ned S Wingreen
doi:10.1038/msb.2008.49
Published online: 05 August 2008
Membrane identity and GTPase cascades regulated by toggle and cut-out switches
Perla Del Conte-Zerial, Lutz Brusch, Jochen C Rink, Claudio Collinet, Yannis Kalaidzidis, Marino Zerial & Andreas Deutsch
doi:10.1038/msb.2008.45
Published online: 15 July 2008
Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model
Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Serge Rezzi, Ziad Ramadan, Emma Peré-Trepat, Florence Rochat, Christine Cherbut, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes & Jeremy K Nicholson
doi:10.1038/msb.2008.40
Published online: 15 July 2008
From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactions
Igor Ulitsky, Tomer Shlomi, Martin Kupiec & Ron Shamir
doi:10.1038/msb.2008.42
Published online: 15 July 2008
Parasites lead to evolution of robustness against gene loss in host signaling networks
Marcel Salathé & Orkun S Soyer
doi:10.1038/msb.2008.44
Published online: 15 July 2008
Gene network dynamics controlling keratinocyte migration
Hauke Busch, David Camacho-Trullio, Zbigniew Rogon, Kai Breuhahn, Peter Angel, Roland Eils & Axel Szabowski
doi:10.1038/msb.2008.36
Published online: 01 July 2008
Reports
Models from experiments: combinatorial drug perturbations of cancer cells
Sven Nelander, Weiqing Wang, Björn Nilsson, Qing-Bai She, Christine Pratilas, Neal Rosen, Peter Gennemark & Chris Sander
doi:10.1038/msb.2008.53
Published online: 02 September 2008
Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response
Song Chou, Su Zhao, You Song, Haoping Liu & Qing Nie
doi:10.1038/msb.2008.47
Published online: 05 August 2008
Survival of the sparsest: robust gene networks are parsimonious
Robert D Leclerc
doi:10.1038/msb.2008.52
Published online: 05 August 2008
News & Views
When microarrays Met epidermal-cell migration
Kevin A Janes
doi:10.1038/msb.2008.41
Published online: 01 July 2008
Perspectives
High-order combination effects and biological robustness
Joseph Lehár, Andrew Krueger, Grant Zimmermann & Alexis Borisy
doi:10.1038/msb.2008.51
Published online: 05 August 2008
Life Sciences and the web: a new era for collaboration
Jonathan A Sagotsky, Le Zhang, Zhihui Wang, Sean Martin & Thomas S Deisboeck
doi:10.1038/msb.2008.39
Published online: 01 July 2008
Corrigendum
Increased glycolytic flux as an outcome of whole-genome duplication in yeast
Gavin C Conant & Kenneth H Wolfe
doi:10.1038/msb200846
Published online: 01 July 2008
More systems biology from NPG & EMBO
A selection of relevant articles hosted by Nature Publishing Group are listed below. More articles can be found on the Systems biology Subject Area page.
