Insert Citation

Questions concerning the paper should be addressed to the corresponding author. Alexander Hoffmann (ahoffmann@ucsd.edu)

The original model was written and simulated within MathWorks MatLab 2006a using the ode15s (stiff/NDF) solver. It is highly recommended that those wanting to model this system use the MatLab version which we will freely provide upon request. As always, simulation results vary according to the numerical solver used.

Translation to SBML Level 2.1 was performed via reconstruction of the model within MathWorks SimBiology Desktop (version 2.1) followed by an Export to SBML.

tr2a tr3a IkBa_mRNA tr1a IkBa_mRNA a1 IkBa_cytoplasm IKK d1_1 IkBaIKK a4_1 IkBa_cytoplasm NFkB_cytoplasm d4_1 IkBaNFkB_cytoplasm a4_2 IkBa_nucleus NFkB_nucleus d4_2 IkBaNFkB_nucleus a7 IkBaNFkB_cytoplasm IKK d1_2 IkBaIKKNFkB a4_3 IkBaIKK NFkB_cytoplasm d4_3 IkBaIKKNFkB deg1_c IkBa_cytoplasm deg1_n IkBa_nucleus deg4_n IkBaNFkB_nucleus deg4_c IkBaNFkB_cytoplasm r1 IkBaIKK r4 IkBaIKKNFkB tp1a IkBa_cytoplasm tp2a IkBa_nucleus k2_a IkBaNFkB_nucleus k2_b IkBbNFkB_nucleus tp1b IkBb_cytoplasm tp2b IkBb_nucleus r5 IkBbIKKNFkB r2 IkBbIKK deg5_c IkBbNFkB_cytoplasm deg5_n IkBbNFkB_nucleus deg2_n IkBb_nucleus deg2_c IkBb_cytoplasm a5_3 IkBbIKK NFkB_cytoplasm d5_3 IkBbIKKNFkB a8 IkBbNFkB_cytoplasm IKK d2_2 IkBbIKKNFkB a5_2 IkBb_nucleus NFkB_nucleus d5_2 IkBbNFkB_nucleus a5_1 IkBb_cytoplasm NFkB_cytoplasm d5_1 IkBbNFkB_cytoplasm a2 IkBb_cytoplasm IKK d2_1 IkBbIKK tr1b IkBb_mRNA tr3b IkBb_mRNA tr2b k1_2 NFkB_cytoplasm k1_1 NFkB_nucleus tr2e tr3e IkBe_mRNA tr1e IkBe_mRNA a3 IkBe_cytoplasm IKK d3_1 IkBeIKK a6_1 IkBe_cytoplasm NFkB_cytoplasm d6_1 IkBeNFkB_cytoplasm a6_2 IkBe_nucleus NFkB_nucleus d6_2 IkBeNFkB_nucleus a9 IkBeNFkB_cytoplasm IKK d3_2 IkBeIKKNFkB a6_3 IkBeIKK NFkB_cytoplasm d6_3 IkBeIKKNFkB deg3_c IkBe_cytoplasm deg3_n IkBe_nucleus deg6_n IkBeNFkB_nucleus deg6_c IkBeNFkB_cytoplasm r3 IkBeIKK r6 IkBeIKKNFkB tp1e IkBe_cytoplasm tp2e IkBe_nucleus k2_e IkBeNFkB_nucleus IKK_deg IKK tr2a_i NFkB_nucleus 2