FIGURE 1
FROM:
Network-based global inference of human disease genes
Xuebing Wu, Rui Jiang, Michael Q Zhang & Shao Li
doi:10.1038/msb.2008.27
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Scoring scheme of CIPHER. First, the human phenotype network, protein network, and gene–phenotype network are assembled into an integrated network. Then, to score a particular phenotype–gene pair (p, g), the phenotype similarity profile for p is extracted and the gene closeness profile for g is computed from the integrated network. Finally, the linear correlation of the two profiles is calculated and assigned as the concordance score between the phenotype p and the gene g.
