FIGURE 1 

Schematic of NF-B dynamics in response to persistent TNF. (A) Oscillatory time course of NF-B in response to TNF in cells whose only classical IB is IB (see also BioModels database http://www.ebi.ac.uk/biomodels, accession ID BIOMD0000000139). (B) Characteristic biphasic time course of NF-B signaling in response to TNF in various wild-type cells. NF-B activity peaks around 30 min, drops to basal levels around 1 h, and rises to an intermediate level thereafter (see also BioModels accession ID BIOMD0000000140).