Volume 5
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No. 4 April 2024
Piecing together the puzzle of breast cancerMulti-omics analyses of breast tumor samples from Chinese patients add more pieces to the puzzle of breast cancer.
See Jiang et al.
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No. 3 March 2024
γδ T cells as a target of checkpoint inhibitionIntratumoral PD-1+Vγ1+ cells display an exhaustion program similar to that of αβ T cells, can be derepressed by checkpoint inhibitors and are predictive of the response to anti-PD-1 in patients with melanoma, specifically those with low levels of neoantigens.
See Davies et al.
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No. 2 February 2024
Dendritic cells for cancer immunotherapyA cell-therapy platform based on dendritic cell progenitors that express immunostimulatory cytokines has shown anti-tumor efficacy in melanoma and liver cancer models in an antigen-agnostic manner.
See Ghasemi et al.
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No. 1 January 2024
Lymphatic endothelial-like cells promote glioblastomaIn glioblastoma, lymphatic endothelial-like cells coexist with blood endothelial cells in the brain parenchyma and promote cancer stem cell growth via altered metabolism, providing a therapeutic vulnerability for this deadly disease.
See Zhao et al.