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    Cancer stem cells are defined as those cells within a tumour that can self-renew and drive tumorigenesis. Rare cancer stem cells have been isolated from a number of human tumours, including haematopoietic, brain, colon and breast cancers. The cancer stem-cell concept has important implications for cancer therapy. However, the generality of the cancer stem-cell hypothesis has also been challenged, most recently in a paper by Sean Morrison and colleagues; Morrison also talks to Nature in this week's podcast.

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  • This week on the Nature Podcast

    This week, we discover what proportion of cancer cells actually form tumours, try to predict the size of future tsunamis, find out what's in store for farming, and talk to stargazers who have spied a blast from the past.

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  • Nature Milestones in Cytoskeleton

    Milestones in Cytoskeleton focuses on ground-breaking advances in cytoskeleton research. Developments in the last 60 years range from the discovery of actomyosin to the identification of molecular motors, and from fluorescence analogue cytochemistry and differential interference contrast microscopy to single molecule in vitro assays and optical traps.

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