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Nature 415, 276-277 (17 January 2002) | doi:10.1038/415276a

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Cell biology: Chloride channels are different

Thomas J. Jentsch

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Proteins that conduct chloride ions are vital for a range of cellular processes. The long-awaited crystal structure of a chloride channel shows what these proteins look like, and gives hints about how they work.

Ion channels are proteins with a seemingly simple task — to allow the passive flow of ions across biological membranes. But this process requires more sophistication than one would imagine.