Table of contents
Volume 422 Number 6934 pp787-929
Editorial
Disease insights from stem cells p787
Confronted by religious and political opposition, proponents of embryonic-stem-cell research need to draw attention not only to new therapies but also to the understanding of diseases that they could soon yield.
doi:10.1038/422787a
News
Historians pool resources to halt trade in Iraq's stolen treasures p789
Hannah Hoag
doi:10.1038/422789a
US debates future of Iraqi scientists p789
Erika Check
doi:10.1038/422789b
India pledges deluge of funds to water plan p790
K. S. Jayaraman
doi:10.1038/422790a
Biotech firms pin hopes on defence p790
Helen Pearson
doi:10.1038/422790b
Biologists deploy database to quash drug-resistant bacteria p791
Tom Clarke
doi:10.1038/422791a
National Academies launch grants for interdisciplinary work p791
Erika Check
doi:10.1038/422791b
University faces up to wartime use of slaves p792
Alison Abbott
doi:10.1038/422792a
Atlantic cod meet icy death p792
Hannah Hoag
doi:10.1038/422792b
Lie probes to continue at US weapons labs p793
Geoff Brumfiel
doi:10.1038/422793a
Agent Orange health investigation stuck at square one p793
Declan Butler
doi:10.1038/422793b
news feature
Rice genome: A recipe for revolution? p796
Sequencing the DNA of the world's leading food crop was the easy part. Now comes the tricky task of turning our new knowledge of the rice genome into agricultural and economic gains. David Cyranoski reports.
David Cyranoski
doi:10.1038/422796a
The Grid: Tomorrow's computing today p799
The physics lab that gave us the World Wide Web is now gearing up to make the first practical deployment of the Internet's next big thing: the Grid. Declan Butler takes a test drive.
Declan Butler
doi:10.1038/422799a
Correspondence
Unrestricted free access works and must continue p801
Bioinformatics researchers shouldn't need coercion to act responsibly and collegially.
Steven Salzberg, Ewan Birney, Sean Eddy and Owen White
doi:10.1038/422801a
Watching an IT icon slide into history p801
W. John Cram
doi:10.1038/422801b
Secrecy is increasing in step with competition p801
John P. Walsh and Wei Hong
doi:10.1038/422801c
Pre-genomics training hinders Indian biotech p802
R. M. Ranganath
doi:10.1038/422802a
Should tobacco ban rule out governments too? p802
Richard S. Jope
doi:10.1038/422802b
Commentaries
Who cares about the double helix? p803
Collective memory links the past to the future in science as well as history.
doi:10.1038/422803a
DNA from Alberts to Zinder p806
doi:10.1038/422806a
BA_SB
Life, the movie p809
Fifty years after revealing the structure of DNA, James Watson looks back.
Maxine Singer reviews DNA: The Secret of Life by James D. Watson, Andrew Berry and Alfred A. Knopf
doi:10.1038/422809a
A final call for peace p810
David Hull reviews The Hedgehog, the Fox, and the Magister's Pox: Mending the Gap Between Science and the Humanities by Stephen Jay Gould
doi:10.1038/422810a
Einstein's view of Germany p811
Freeman J. Dyson reviews Einstein in Berlin by Thomas Levenson
doi:10.1038/422811a
Getting heated over glaciation p812
Euan Nisbet reviews Snowball Earth by Gabrielle Walker
doi:10.1038/422812a
Gould and God p813
Jerry A. Coyne reviews A Devil's Chaplain by Richard Dawkins
doi:10.1038/422813a
The writing on the slate p814
Andrew Berry reviews Nature via Nurture: Genes, Experience and What Makes Us Human by Matt Ridley
doi:10.1038/422814a
The evolutionary blackbird p815
Carl Zimmer reviews The Story of Life by Richard Southwood
doi:10.1038/422815a
Metabolic gardening p816
E. C. Slater reviews Wandering in the Gardens of the Mind: Peter Mitchell and the Making of Glynn by John Prebble and Bruce Weber
doi:10.1038/422816a
History in the making p816
doi:10.1038/422816b
Science in culture p817
Lynn Gamwell reviews
doi:10.1038/422817a
News and Views
Genome sequencing: Revelations from a bread mould p821
The filamentous fungus Neurospora crassa is an organism much loved by geneticists. Its genome sequence has now been unveiled, and includes some surprises — such as the relatively high number of genes.
Jonathan Arnold and Nelson Hilton
doi:10.1038/422821a
Quantum electronics: The electron is cool p822
Temperature is an awkward concept for a single particle, but the energy of the particle's 'quivering' is a useful substitute. Feedback control of this motion can be used to cool a single electron to very low temperature.
Peter E. Toschek
doi:10.1038/422822a
Stem cells: Fusion brings down barriers p823
It remains uncertain how tissue-specific stem cells could generate the mature cell types of another tissue. In one instance, where bone-marrow-derived stem cells repair damaged liver in mice, cell fusion is the answer.
Alexander Medvinsky and Austin Smith
doi:10.1038/422823a
Astronomy: Telling the tale of the first stars p825
HE0107–5240 is a star in more than one sense of the word. Chemically, it is the most primitive object yet discovered, and it is at the centre of debate about the origins of the first elements in the Universe.
Timothy C. Beers
doi:10.1038/422825a
Ecology: A liverwort cheat p826
Tim Lincoln
doi:10.1038/422826a
Cancer: Escape from inhibition p827
Mutations in the Abl protein cause some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.
Sara A. Courtneidge
doi:10.1038/422827a
100 and 50 years ago p827
doi:10.1038/422827b
news and view in brief p829
doi:10.1038/422829a
Brief Communications
Aetiology: The earliest recorded plant virus disease p831
Pathogenic DNA paints summer foliage gold, and inspired a poet over a millennium ago.
Keith Saunders, Ian D. Bedford, Tetsukazu Yahara and John Stanley
doi:10.1038/422831a
First paragraph | Full Text | PDF (104K)
Nutritional biochemistry: A new redox-cofactor vitamin for mammals p832
Takaoki Kasahara and Tadafumi Kato
doi:10.1038/422832a
First paragraph | Full Text | PDF (68K)
Evolutionary biology (communication arising): Why do birds engage in extra-pair copulation? p833
Simon C. Griffith and Robert Montgomerie
doi:10.1038/422833a
First paragraph | Full Text | PDF (72K)
Evolutionary biology (communication arising): Why do birds engage in extra-pair copulation? p833
Donald Blomqvist, Malte Andersson, Clemens Küpper, Innes C. Cuthill, János Kis, Richard B. Lanctot, Brett K. Sandercock, Tamás Székely, Johan Wallander and Bart Kempenaers
doi:10.1038/422833b
First paragraph | Full Text | PDF (72K)
Astrophysics: How did the metals in a giant star originate? p834
Piercarlo Bonifacio, Marco Limongi and Alessandro Chieffi
doi:10.1038/422834a
First paragraph | Full Text | PDF (62K)
addendum: Adult persistence of head-turning asymmetry p834
O. Güntürkün
doi:10.1038/422834b
Feature
A vision for the future of genomics research p835
A blueprint for the genomic era.
Francis S. Collins, Eric D. Green, Alan E. Guttmacher and Mark S. Guyer
Review
Genetics and the making of Homo sapiens p849
Sean B. Carroll
doi:10.1038/nature01495
Abstract | Full Text | PDF (310K)
Article
The genome sequence of the filamentous fungus Neurospora crassa p859
James E. Galagan, Sarah E. Calvo, Katherine A. Borkovich, Eric U. Selker, Nick D. Read, David Jaffe, William FitzHugh, Li-Jun Ma, Serge Smirnov, Seth Purcell, Bushra Rehman, Timothy Elkins, Reinhard Engels, Shunguang Wang, Cydney B. Nielsen, Jonathan Butler, Matthew Endrizzi, Dayong Qui, Peter Ianakiev, Deborah Bell-Pedersen, Mary Anne Nelson, Margaret Werner-Washburne, Claude P. Selitrennikoff, John A. Kinsey, Edward L. Braun, Alex Zelter, Ulrich Schulte, Gregory O. Kothe, Gregory Jedd, Werner Mewes, Chuck Staben, Edward Marcotte, David Greenberg, Alice Roy, Karen Foley, Jerome Naylor, Nicole Stange-Thomann, Robert Barrett, Sante Gnerre, Michael Kamal, Manolis Kamvysselis, Evan Mauceli, Cord Bielke, Stephen Rudd, Dmitrij Frishman, Svetlana Krystofova, Carolyn Rasmussen, Robert L. Metzenberg, David D. Perkins, Scott Kroken, Carlo Cogoni, Giuseppe Macino, David Catcheside, Weixi Li, Robert J. Pratt, Stephen A. Osmani, Colin P. C. DeSouza, Louise Glass, Marc J. Orbach, J. Andrew Berglund, Rodger Voelker, Oded Yarden, Michael Plamann, Stephan Seiler, Jay Dunlap, Alan Radford, Rodolfo Aramayo, Donald O. Natvig, Lisa A. Alex, Gertrud Mannhaupt, Daniel J. Ebbole, Michael Freitag, Ian Paulsen, Matthew S. Sachs, Eric S. Lander, Chad Nusbaum and Bruce Birren
doi:10.1038/nature01554
Abstract | Full Text | PDF (641K) | Supplementary information
See also: News and Views by Arnold & Hilton
Letters to Nature
Low-mass relics of early star formation p869
R. Schneider, A. Ferrara, R. Salvaterra, K. Omukai and V. Bromm
doi:10.1038/nature01579
First paragraph | Full Text | PDF (185K)
First-generation black-hole-forming supernovae and the metal abundance pattern of a very iron-poor star p871
Hideyuki Umeda and Ken'ichi Nomoto
doi:10.1038/nature01571
First paragraph | Full Text | PDF (198K)
No mixing of superconductivity and antiferromagnetism in a high-temperature superconductor p873
I. Bozovic, G. Logvenov, M. A. J. Verhoeven, P. Caputo, E. Goldobin and T. H. Geballe
doi:10.1038/nature01544
First paragraph | Full Text | PDF (405K)
Experimental detection of 
-particles from the radioactive decay of natural bismuth p876
Pierre de Marcillac, Noël Coron, Gérard Dambier, Jacques Leblanc and Jean-Pierre Moalic
doi:10.1038/nature01541
First paragraph | Full Text | PDF (3,600K) | Supplementary information
Magmatic events can produce rapid changes in hydrothermal vent chemistry p878
Marvin D. Lilley, David A. Butterfield, John E. Lupton and Eric J. Olson
First paragraph | Full Text | PDF (269K) | Supplementary information
A test of the unified neutral theory of biodiversity p881
Brian J. McGill
doi:10.1038/nature01583
First paragraph | Full Text | PDF (226K) | Supplementary information
Ecological interference between fatal diseases p885
P. Rohani, C. J. Green, N. B. Mantilla-Beniers and B. T. Grenfell
doi:10.1038/nature01542
First paragraph | Full Text | PDF (380K) | Supplementary information
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing p888
Shuang-Xi Ren, Gang Fu, Xiu-Gao Jiang, Rong Zeng, You-Gang Miao, Hai Xu, Yi-Xuan Zhang, Hui Xiong, Gang Lu, Ling-Feng Lu, Hong-Quan Jiang, Jia Jia, Yue-Feng Tu, Ju-Xing Jiang, Wen-Yi Gu, Yue-Qing Zhang, Zhen Cai, Hai-Hui Sheng, Hai-Feng Yin, Yi Zhang, Gen-Feng Zhu, Ma Wan, Hong-Lei Huang, Zhen Qian, Sheng-Yue Wang, Wei Ma, Zhi-Jian Yao, Yan Shen, Bo-Qin Qiang, Qi-Chang Xia, Xiao-Kui Guo, Antoine Danchin, Isabelle Saint Girons, Ronald L. Somerville, Yu-Mei Wen, Man-Hua Shi, Zhu Chen, Jian-Guo Xu and Guo-Ping Zhao
doi:10.1038/nature01597
First paragraph | Full Text | PDF (772K) | Supplementary information
The methylated component of the Neurospora crassa genome p893
Eric U. Selker, Nikolaos A. Tountas, Sally H. Cross, Brian S. Margolin, Jonathan G. Murphy, Adrian P. Bird and Michael Freitag
doi:10.1038/nature01564
First paragraph | Full Text | PDF (691K) | Supplementary information
Cell fusion is the principal source of bone-marrow-derived hepatocytes p897
Xin Wang, Holger Willenbring, Yassmine Akkari, Yumi Torimaru, Mark Foster, Muhsen Al-Dhalimy, Eric Lagasse, Milton Finegold, Susan Olson and Markus Grompe
doi:10.1038/nature01531
First paragraph | Full Text | PDF (464K)
See also: News and Views by Medvinsky & Smith
Transplanted bone marrow regenerates liver by cell fusion p901
George Vassilopoulos, Pei-Rong Wang and David W. Russell
doi:10.1038/nature01539
First paragraph | Full Text | PDF (481K) | Supplementary information
See also: News and Views by Medvinsky & Smith
Chibby, a nuclear 
-catenin-associated antagonist of the Wnt/Wingless pathway p905
Ken-Ichi Takemaru, Shinji Yamaguchi, Young Sik Lee, Yang Zhang, Richard W. Carthew and Randall T. Moon
doi:10.1038/nature01570
First paragraph | Full Text | PDF (639K) | Supplementary information
DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing p909
Alexander Saveliev, Christopher Everett, Tammy Sharpe, Zoë Webster and Richard Festenstein
doi:10.1038/nature01596
First paragraph | Full Text | PDF (375K) | Supplementary information
Technology Features
Pharmacogenetics and Genotyping: On the trail of SNPs p917
Extracting useful data from the human genome sequence is a major challenge. Lisa Melton examines the early steps towards personal genotyping.
Lisa Melton
doi:10.1038/422917a
Crime busters p917
doi:10.1038/422917b
Risk assessment p919
doi:10.1038/422919a
Haplotypes of pools? p921
doi:10.1038/422921a
table of suppliers p924
doi:10.1038/422924a
Naturejobs
ProspectsBeyond the helix p927
Paul Smaglik
doi:10.1038/nj6934-927a
SPECIAL REPORT
Stem-cell research p928
Complex political, ethical and legal issues surround research on human embryonic stem cells. Diane Gershon explores the field's long-term career prospects.
Diane Gershon
doi:10.1038/nj6934-928a
