Table of contents
Volume 425 Number 6960 pp749-883
Editorials
Pharmacogenetics to come p749
Genetically selected medicine has been much hyped but has significant potential. Regulation and treatment will depend on pharmaceutical companies more readily sharing genetic data.
doi:10.1038/425749a
New access for agriculture p749
A United Nations scheme launched last week extends unrestricted access to Nature's content within developing countries.
doi:10.1038/425749b
News
Biosafety trials darken outlook for transgenic crops in Europe p751
Jim Giles
doi:10.1038/425751a
Drugs bust reveals athletes' secret steroid p752
Jonathan Knight
doi:10.1038/425752a
Open access wins German support p752
Quirin Schiermeier
doi:10.1038/425752b
Fish farms' threat to salmon stocks exposed p753
Quirin Schiermeier
doi:10.1038/425753a
Opossum hops over kangaroo to top of genome list p753
Carina Dennis
doi:10.1038/425753b
Biologists seek havens for species at risk p754
Rex Dalton
doi:10.1038/425754a
Standards-lab staff up in arms over military link p754
Jim Giles
doi:10.1038/425754b
News Features
Special section on human genetics: The rough guide to the genome p758
A new effort to map human genetic variation should provide a shortcut for researchers trying to uncover the roots of disease. Carina Dennis profiles the 'HapMap' project.
doi:10.1038/425758a
Special section on human genetics: With your genes? Take one of these, three times a day p760
Truly 'personalized' medicine remains a distant goal. But researchers are now thinking about how to use genomic data to avoid prescribing drugs that may kill, or won't work. Alison Abbott reports.
doi:10.1038/425760a
Correspondence
Bioethics needs a distinct voice if it is to aid science p763
Neither scientific knowledge nor gut feeling is enough to support decision-making.
Alfons Lawen
doi:10.1038/425763a
Bioethics: role of religion cannot be ignored p763
Stephen J. McSorley
doi:10.1038/425763b
Unnatural coverage of Chernobyl tragedy p763
Oliver R. W. Pergams
doi:10.1038/425763c
India's mission to the Moon is worthwhile p763
Roddam Narasimha
doi:10.1038/425763d
Books and Arts
Outstanding in his field p765
James Clerk Maxwell's work on the electromagnetic field started a revolution.
John Maddox reviews The Man Who Changed Everything: The Life of James Clerk Maxwell by Basil Mahon
doi:10.1038/425765a
Harnessing science for Hitler p766
Kristie Macrakis reviews Hitler's Scientists: Science, War and the Devil's Pact by John Cornwell
doi:10.1038/425766a
The eyes have it p767
Richard E. Lenski reviews Life's Solution: Inevitable Humans in a Lonely Universe by Simon Conway Morris
doi:10.1038/425767a
Listen, learn and construct p768
Eve V. Clark reviews Constructing a Language: A Usage-Based Theory of Language Acquisition by Michael Tomasello
doi:10.1038/425768a
Changing the world p769
Laurent Keller reviews Niche Construction: The Neglected Process in Evolution by F. John Odling-Smee, Kevin N. Laland and Marcus W. Feldman
doi:10.1038/425769a
An enigma for all seasons p770
Stuart Young reviews Prof: The Life of Frederick LindemannbyAdrian Fort
doi:10.1038/425770a
A feather in the cap for bird breeders p772
Jerry A. Coyne reviews The Red Canary: The Story of the First Genetically Engineered Animal by Tim Birkhead
doi:10.1038/425772a
Lifelines
Vera Rubin: The observer p773
Vera Rubin, senior fellow in the Department of Terrestrial Magnetism, Carnegie Institution of Washington, is wife, parent and astronomer, in that order. She and husband Bob have four PhD offspring: two geologists, an astronomer and a mathematician.
doi:10.1038/425773a
News and Views
Genomics: Six is seventh p775
The finished sequence of human chromosome 6 reveals an abundance of biological information previously buried within the draft of the human genome, and illustrates the increasing power of comparative genomics.
Jane Grimwood and Jeremy Schmutz
doi:10.1038/425775a
100 and 50 years ago p776
doi:10.1038/425776a
Applied physics: To catch a photon p777
Astronomers crave a detector sensitive enough to detect a single photon and determine its energy. A new single-pixel device can do this, and could also be built up into a large array suitable for a telescope.
Daniel E. Prober
doi:10.1038/425777a
Genetics: Secrets of a porkier porker p777
Chris Gunter
doi:10.1038/425777b
Stem cells: Interactive niches p778
The microenvironment, or niche, in which stem cells reside controls their renewal and maturation. The niche that regulates blood-forming stem cells in adult animals has eluded researchers — until now.
Ihor R. Lemischka and Kateri A. Moore
doi:10.1038/425778a
Metabolism: It's in the genes p779
Warm-blooded animals of the same species, living in different climates, have different metabolic rates. In birds, this variation is not only due to physiological adaptation — it is inherent in the animals' genes.
Robert W. Furness
doi:10.1038/425779a
Cancer: A twist in a hedgehog's tale p780
The genetics of development can often explain the genesis of cancer. This now seems to be true for cancers of the gut, but the patterns of gene expression in these tumours tell a tale with a twist.
Matthew P. Scott
doi:10.1038/425780a
Earth science: How do your mountains grow? p781
Nicola Jones
doi:10.1038/425781a
Evolution: Ending incongruence p782
Recovering the true evolutionary history of any group of organisms has seemed impossible. The availability of large amounts of genomic data promises an era in which the uncertainties are better constrained.
Henry Gee
doi:10.1038/425782a
Brief Communications
Life history: Changing sex at the same relative body size p783
Similar forces may select for gender switching across taxa in all animals with this facility.
David J. Allsop and Stuart A. West
doi:10.1038/425783a
First paragraph | Full Text | PDF (144K)
Ancient materials: Analysis of a pharaonic embalming tar p784
Johann Koller, Ursula Baumer, Yoka Kaup, Mirjam Schmid and Ulrich Weser
doi:10.1038/425784a
First paragraph | Full Text | PDF (86K) | Supplementary information
Review
The nature of human altruism p785
Ernst Fehr and Urs Fischbacher
doi:10.1038/nature02043
Abstract | Full Text | PDF (266K)
Articles
Cenozoic climate change as a possible cause for the rise of the Andes p792
Simon Lamb and Paul Davis
doi:10.1038/nature02049
Abstract | Full Text | PDF (499K)
Genome-scale approaches to resolving incongruence in molecular phylogenies p798
Antonis Rokas, Barry L. Williams, Nicole King and Sean B. Carroll
doi:10.1038/nature02053
Abstract | Full Text | PDF (686K) | Supplementary information
See also: News and Views by Gee
The DNA sequence and analysis of human chromosome 6 p805
A. J. Mungall, S. A. Palmer, S. K. Sims, C. A. Edwards, J. L. Ashurst, L. Wilming, M. C. Jones, R. Horton, S. E. Hunt, C. E. Scott, J. G. R. Gilbert, M. E. Clamp, G. Bethel, S. Milne, R. Ainscough, J. P. Almeida, K. D. Ambrose, T. D. Andrews, R. I. S. Ashwell, A. K. Babbage, C. L. Bagguley, J. Bailey, R. Banerjee, D. J. Barker, K. F. Barlow, K. Bates, D. M. Beare, H. Beasley, O. Beasley, C. P. Bird, S. Blakey, S. Bray-Allen, J. Brook, A. J. Brown, J. Y. Brown, D. C. Burford, W. Burrill, J. Burton, C. Carder, N. P. Carter, J. C. Chapman, S. Y. Clark, G. Clark, C. M. Clee, S. Clegg, V. Cobley, R. E. Collier, J. E. Collins, L. K. Colman, N. R. Corby, G. J. Coville, K. M. Culley, P. Dhami, J. Davies, M. Dunn, M. E. Earthrowl, A. E. Ellington, K. A. Evans, L. Faulkner, M. D. Francis, A. Frankish, J. Frankland, L. French, P. Garner, J. Garnett, M. J. R. Ghori, L. M. Gilby, C. J. Gillson, R. J. Glithero, D. V. Grafham, M. Grant, S. Gribble, C. Griffiths, M. Griffiths, R. Hall, K. S. Halls, S. Hammond, J. L. Harley, E. A. Hart, P. D. Heath, R. Heathcott, S. J. Holmes, P. J. Howden, K. L. Howe, G. R. Howell, E. Huckle, S. J. Humphray, M. D. Humphries, A. R. Hunt, C. M. Johnson, A. A. Joy, M. Kay, S. J. Keenan, A. M. Kimberley, A. King, G. K. Laird, C. Langford, S. Lawlor, D. A. Leongamornlert, M. Leversha, C. R. Lloyd, D. M. Lloyd, J. E. Loveland, J. Lovell, S. Martin, M. Mashreghi-Mohammadi, G. L. Maslen, L. Matthews, O. T. McCann, S. J. McLaren, K. McLay, A. McMurray, M. J. F. Moore, J. C. Mullikin, D. Niblett, T. Nickerson, K. L. Novik, K. Oliver, E. K. Overton-Larty, A. Parker, R. Patel, A. V. Pearce, A. I. Peck, B. Phillimore, S. Phillips, R. W. Plumb, K. M. Porter, Y. Ramsey, S. A. Ranby, C. M. Rice, M. T. Ross, S. M. Searle, H. K. Sehra, E. Sheridan, C. D. Skuce, S. Smith, M. Smith, L. Spraggon, S. L. Squares, C. A. Steward, N. Sycamore, G. Tamlyn-Hall, J. Tester, A. J. Theaker, D. W. Thomas, A. Thorpe, A. Tracey, A. Tromans, B. Tubby, M. Wall, J. M. Wallis, A. P. West, S. S. White, S. L. Whitehead, H. Whittaker, A. Wild, D. J. Willey, T. E. Wilmer, J. M. Wood, P. W. Wray, J. C. Wyatt, L. Young, R. M. Younger, D. R. Bentley, A. Coulson, R. Durbin, T. Hubbard, J. E. Sulston, I. Dunham, J. Rogers and S. Beck
doi:10.1038/nature02055
Abstract | Full Text | PDF (469K) | Supplementary information
See also: News and Views by Grimwood & Schmutz
Letters to Nature
The formation of the first low-mass stars from gas with low carbon and oxygen abundances p812
Volker Bromm and Abraham Loeb
doi:10.1038/nature02071
First paragraph | Full Text | PDF (191K)
A coherent three-dimensional Fermi surface in a high-transition-temperature superconductor p814
N. E. Hussey, M. Abdel-Jawad, A. Carrington, A. P. Mackenzie and L. Balicas
doi:10.1038/nature01981
First paragraph | Full Text | PDF (419K)
A broadband superconducting detector suitable for use in large arrays p817
Peter K. Day, Henry G. LeDuc, Benjamin A. Mazin, Anastasios Vayonakis and Jonas Zmuidzinas
doi:10.1038/nature02037
First paragraph | Full Text | PDF (302K)
See also: News and Views by Prober
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension p821
Tobias Baumgart, Samuel T. Hess and Watt W. Webb
doi:10.1038/nature02013
First paragraph | Full Text | PDF (448K) | Supplementary information
Cool Indonesian throughflow as a consequence of restricted surface layer flow p824
Arnold L. Gordon, R. Dwi Susanto and Kevin Vranes
doi:10.1038/nature02038
First paragraph | Full Text | PDF (394K)
Independent rate and temporal coding in hippocampal pyramidal cells p828
John Huxter, Neil Burgess and John O'Keefe
doi:10.1038/nature02058
First paragraph | Full Text | PDF (1,196K) | Supplementary information
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig p832
Anne-Sophie Van Laere, Minh Nguyen, Martin Braunschweig, Carine Nezer, Catherine Collette, Laurence Moreau, Alan L. Archibald, Chris S. Haley, Nadine Buys, Michael Tally, Göran Andersson, Michel Georges and Leif Andersson
doi:10.1038/nature02064
First paragraph | Full Text | PDF (353K) | Supplementary information
Identification of the haematopoietic stem cell niche and control of the niche size p836
Jiwang Zhang, Chao Niu, Ling Ye, Haiyang Huang, Xi He, Wei-Gang Tong, Jason Ross, Jeff Haug, Teri Johnson, Jian Q. Feng, Stephen Harris, Leanne M. Wiedemann, Yuji Mishina and Linheng Li
doi:10.1038/nature02041
First paragraph | Full Text | PDF (505K) | Supplementary information
Osteoblastic cells regulate the haematopoietic stem cell niche p841
L. M. Calvi, G. B. Adams, K. W. Weibrecht, J. M. Weber, D. P. Olson, M. C. Knight, R. P. Martin, E. Schipani, P. Divieti, F. R. Bringhurst, L. A. Milner, H. M. Kronenberg and D. T. Scadden
doi:10.1038/nature02040
First paragraph | Full Text | PDF (486K) | Supplementary information
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours p846
David M. Berman, Sunil S. Karhadkar, Anirban Maitra, Rocio Montes de Oca, Meg R. Gerstenblith, Kimberly Briggs, Antony R. Parker, Yutaka Shimada, James R. Eshleman, D. Neil Watkins and Philip A. Beachy
doi:10.1038/nature01972
First paragraph | Full Text | PDF (503K) | Supplementary information
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis p851
Sarah P. Thayer, Marina Pasca di Magliano, Patrick W. Heiser, Corinne M. Nielsen, Drucilla J. Roberts, Gregory Y. Lauwers, Yan Ping Qi, Stephan Gysin, Carlos Fernández-del Castillo, Vijay Yajnik, Bozena Antoniu, Martin McMahon, Andrew L. Warshaw and Matthias Hebrok
doi:10.1038/nature02009
First paragraph | Full Text | PDF (530K) | Supplementary information
Yip3 catalyses the dissociation of endosomal Rab–GDI complexes p856
Ulf Sivars, Dikran Aivazian and Suzanne R. Pfeffer
doi:10.1038/nature02057
First paragraph | Full Text | PDF (318K) | Supplementary information
Targets of the cyclin-dependent kinase Cdk1 p859
Jeffrey A. Ubersax, Erika L. Woodbury, Phuong N. Quang, Maria Paraz, Justin D. Blethrow, Kavita Shah, Kevan M. Shokat and David O. Morgan
doi:10.1038/nature02062
First paragraph | Full Text | PDF (360K) | Supplementary information
Technology Features
Seeing is believing p867
Peering down an eyepiece is becoming a thing of the past. Tim Chapman takes a look into the digital world of a new generation of microscopes and imaging systems.
Tim Chapman
doi:10.1038/425867a
Lighting up the body p867
doi:10.1038/425867b
Easing the strain p869
doi:10.1038/425869a
High throughput goes 3D p871
doi:10.1038/425871a
Scanning the surface p873
doi:10.1038/425873a
table of suppliers p875
doi:10.1038/425875a
Naturejobs
ProspectsRewarding experience p879
Paul Smaglik
doi:10.1038/nj6960-879a
CAREERS AND RECRUITMENT
In search of form and function p880
Rapidly changing technology and an abundance of DNA sequences are creating more job opportunities in functional genomics — particularly for scientists who have been trained outside traditional biology. Hannah Hoag investigates.
Hannah Hoag
doi:10.1038/nj6960-880a
Building bridges p882
The costs of functional genomics can be prohibitive, and job candidates often lack the skills most researchers desire, but many academic settings are creating training schemes and unique institutes to deal with these barriers. Hannah Hoag reports.
Hannah Hoag
doi:10.1038/nj6960-882a
