Table of contents
Volume 429 Number 6992 pp585-683
(this content only available online) indicates content that is available online only
Editorials
Precaution versus principles p585
Constitutional law can make the eyes glaze over, but scientists need to be wary of subtle amendments that may undermine a fundamental liberty enshrined in most constitutions: scientific freedom.
doi:10.1038/429585a
Boosting bioprospects p585
A new approach to registering ownership should rebuild confidence, benefiting all stakeholders.
doi:10.1038/429585b
News
Gene therapists hopeful as trials resume with childhood disease p587
Erika Check
doi:10.1038/429587a
Global fund changes tack on malaria therapy p588
Declan Butler
doi:10.1038/429588a
Biotech industry struggles with generics approval p588
Jonathan Knight
doi:10.1038/429588b
Spitzer sues drug giant for deceiving doctors p589
Meredith Wadman
doi:10.1038/429589a
Net losses pose extinction risk for porpoise p590
Rex Dalton
doi:10.1038/429590a
Critics blast 'premature' paper on adult stem cells p590
Quirin Schiermeier and Martin Leeb
doi:10.1038/429590b
Futuristic centre under fire from German science council p591
Quirin Schiermeier
doi:10.1038/429591a
Nanotech takes small step towards burying 'grey goo' p591
Jim Giles
doi:10.1038/429591b
News Features
Palaeoclimate: Frozen time p596
Researchers have pulled the oldest-yet core of ice from the Antarctic — giving us a 740,000-year record of the planet's climate. Gabrielle Walker braves the cold to find out how they did it, and what they hope to learn.
doi:10.1038/429596a
Natural resources: Bioprospects less than golden p598
The search for potentially valuable natural products is flagging. Could new rules on ownership of these resources give it a boost? Rex Dalton investigates.
doi:10.1038/429598a
Correspondence
Small countries receive even less of a fair deal p601
Governments and companies should intervene to control the price of lab supplies.
Stipan Jonjic and Luka Traven
doi:10.1038/429601a
Fair deal: local factors add to price of supplies p601
Andrew Carr
doi:10.1038/429601b
Fair deal foiled by taxes and exchange rates p601
Josely Chiarella
doi:10.1038/429601c
Commentary
Isolation is not the answer p603
International scientific collaboration is the best defence against bioterror.
doi:10.1038/429603a
Books and Arts
Current affairs p605
The rise to fame of the El Niño climate phenomenon.
Michael J. McPhaden reviews Our Affair with El Niño: How We Transformed an Enchanting Peruvian Current into a Global Climate Hazard by S. George Philander
doi:10.1038/429605a
A helping hand p606
Eve Sweetser reviews Hearing Gesture: How our Hands Help us Think by Susan Goldin-Meadow
doi:10.1038/429606a
Bedside stories p607
John Carmody reviews The Body in the Library: A Literary History of Modern Medicine
doi:10.1038/429607a
Exhibition: Living with luminescence p607
Carina Dennis
doi:10.1038/429607b
Essay
ConceptCausing a commotion p609
Niche construction: do the changes that organisms make to their habitats transform evolution and influence natural selection?
Kevin N. Laland, John Odling-Smee and Marcus W. Feldman
doi:10.1038/429609a
News and Views
Palaeoclimate: A great grand-daddy of ice cores p611
A record of Earth's climate over the past eight ice ages and their associated interglacial periods has been uncovered from a new ice core in Antarctica, almost doubling the age of previous ice-core records.
Jerry F. McManus
doi:10.1038/429611a
Animal Behaviour: Eavesdropping on bats p612
Two investigations into bat echolocation provide striking examples of the sophistication and the possible evolutionary and ecological consequences of variability in call design.
Brock Fenton and John Ratcliffe
doi:10.1038/429612a
Particle physics: From the top... p613
The top quark is by far the heaviest elementary particle known. A measurement of its mass with higher precision has bearing on our understanding of the fundamental interactions of nature.
Georg Weiglein
doi:10.1038/429613a
100 and 50 years ago p614
doi:10.1038/429614a
Interstellar chemistry: Molecular nitrogen in space p615
Astronomers have found evidence of molecular nitrogen in the clouds of gas between the Earth and a distant star. The chemistry involved in the formation of these diffuse clouds might need to be rethought.
Theodore P. Snow
doi:10.1038/429615a
Economics: The wealth of nations p616
A country's affluence depends partly on its institutions. Geographic and other factors yield a fuller explanation, illuminate the origins of 'good' institutions, and suggest targets for foreign aid.
Jared Diamond
doi:10.1038/429616a
Nanophysics: A step up to self-assembly p617
Powerful computer simulations have resolved the mechanism for the nanoscale assembly of the 'hut'-like clusters that form after a few layers of atoms have been deposited on certain solid surfaces.
Kristen Fichthorn and Matthias Scheffler
doi:10.1038/429617a
Molecular medicine: The writing is on the vessel wall p618
Using an integrated approach, it is possible to identify the molecular addresses on blood-vessel walls that are read by blood cells — and, at least in rats, to deliver imaging agents and drugs to specific tissues.
Christopher H. Contag and Michael H. Bachmann
doi:10.1038/429618a
News and views in brief p620
doi:10.1038/429620a
Brief Communications
Palaeontology: Pterosaur embryo from the Early Cretaceous p621
An impressive fossil discovered in China confirms that pterosaurs were egg-layers.
Xiaolin Wang and Zhonghe Zhou
doi:10.1038/429621a
First paragraph | Full Text | PDF (233K)
Top of page
Brief Communications Arising
Palaeobiology: Dutch diaries and the demise of the dodo
Julian Pender Hume, David M. Martill and Christopher Dewdney
doi:10.1038/nature02688
First paragraph | Full Text | PDF (73K)
Articles
Eight glacial cycles from an Antarctic ice core p623
EPICA community members
doi:10.1038/nature02599
Abstract | Full Text | PDF (380K) | Supplementary information
See also: News and Views by McManus
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy p629
Phil Oh, Yan Li, Jingyi Yu, Eberhard Durr, Karolina M. Krasinska, Lucy A. Carver, Jacqueline E. Testa and Jan E. Schnitzer
doi:10.1038/nature02580
Abstract | Full Text | PDF (1,572K) | Supplementary information
See also: News and Views by Contag & Bachmann
Letters to Nature
The interstellar N2 abundance towards HD 124314 from far-ultraviolet observations p636
David C. Knauth, B-G Andersson, Stephan R. McCandliss and H. Warren Moos
doi:10.1038/nature02614
First paragraph | Full Text | PDF (202K) | Supplementary information
See also: News and Views by Snow
A precision measurement of the mass of the top quark p638
DØ Collaboration
doi:10.1038/nature02589
First paragraph | Full Text | PDF (223K)
See also: News and Views by Weiglein
Energy-transfer pumping of semiconductor nanocrystals using an epitaxial quantum well p642
Marc Achermann, Melissa A. Petruska, Simon Kos, Darryl L. Smith, Daniel D. Koleske and Victor I. Klimov
doi:10.1038/nature02571
First paragraph | Full Text | PDF (289K) | Supplementary information
High levels of atmospheric carbon dioxide necessary for the termination of global glaciation p646
Raymond T. Pierrehumbert
doi:10.1038/nature02640
First paragraph | Full Text | PDF (187K) | Supplementary information
Mesozoic origin for West Indian insectivores p649
Alfred L. Roca, Gila Kahila Bar-Gal, Eduardo Eizirik, Kristofer M. Helgen, Roberto Maria, Mark S. Springer, Stephen J. O'Brien and William J. Murphy
doi:10.1038/nature02597
First paragraph | Full Text | PDF (151K) | Supplementary information
Convergence across biomes to a common rain-use efficiency p651
Travis E. Huxman, Melinda D. Smith, Philip A. Fay, Alan K. Knapp, M. Rebecca Shaw, Michael E. Loik, Stanley D. Smith, David T. Tissue, John C. Zak, Jake F. Weltzin, William T. Pockman, Osvaldo E. Sala, Brent M. Haddad, John Harte, George W. Koch, Susan Schwinning, Eric E. Small and David G. Williams
doi:10.1038/nature02561
First paragraph | Full Text | PDF (207K) | Supplementary information
Harmonic-hopping in Wallacea's bats p654
Tigga Kingston and Stephen J. Rossiter
doi:10.1038/nature02487
First paragraph | Full Text | PDF (198K) | Supplementary information
See also: News and Views by Fenton & Ratcliffe
Echolocation signals reflect niche differentiation in five sympatric congeneric bat species p657
Björn M. Siemers and Hans-Ulrich Schnitzler
doi:10.1038/nature02547
First paragraph | Full Text | PDF (279K) | Supplementary information
See also: News and Views by Fenton & Ratcliffe
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast p661
Balázs Papp, Csaba Pál and Laurence D. Hurst
doi:10.1038/nature02636
First paragraph | Full Text | PDF (185K) | Supplementary information
Temporal difference models describe higher-order learning in humans p664
Ben Seymour, John P. O'Doherty, Peter Dayan, Martin Koltzenburg, Anthony K. Jones, Raymond J. Dolan, Karl J. Friston and Richard S. Frackowiak
doi:10.1038/nature02581
First paragraph | Full Text | PDF (257K)
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation p667
Claire Bertet, Lawrence Sulak and Thomas Lecuit
doi:10.1038/nature02590
First paragraph | Full Text | PDF (412K) | Supplementary information
Structure of a complex between a voltage-gated calcium channel 
-subunit and an 
-subunit domain p671
Filip Van Petegem, Kimberly A. Clark, Franck C. Chatelain and Daniel L. Minor, Jr
doi:10.1038/nature02588
First paragraph | Full Text | PDF (394K) | Supplementary information
Structural basis of the 1– subunit interaction of voltage-gated Ca2+ channels p675
Yu-hang Chen, Ming-hui Li, Yun Zhang, Lin-ling He, Yoichi Yamada, Aileen Fitzmaurice, Yang Shen, Hailong Zhang, Liang Tong and Jian Yang
doi:10.1038/nature02641
First paragraph | Full Text | PDF (748K) | Supplementary information
Corrigendum: Photonic structures in biology p680
Pete Vukusic and J. Roy Sambles
doi:10.1038/nature02683
Naturejobs
ProspectsThe power of goodbye p681
Paul Smaglik
doi:10.1038/nj6992-681a
Careers and Recruitment
Testing new ground p682
Diagnosis has traditionally been overshadowed by new drug discoveries. But the expansion of molecular diagnostics is creating new careers for researchers in many fields. Hannah Hoag reports.
Hannah Hoag
doi:10.1038/nj6992-682a
