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Nature 432, 243-249 (11 November 2004) | doi:10.1038/432243a; Published online 10 November 2004

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Cell signalling:  Making connections

Diane Gershon1

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Technological innovations in detecting and studying protein–protein interactions are providing new ways of doing research in cell signalling. Diane Gershon investigates.

Cell-signalling research aims to understand how cells convert extracellular signals into the required cellular responses, and how these pathways can go awry and cause disease. With the emergence of cell signalling as a significant field in its own right over the past few years, a dizzying array of reagents, assays and technologies are now available to help researchers (see 'In the market place').