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Nature 432, 338-341 (18 November 2004) | doi:10.1038/nature03099; Published online 17 November 2004
Open Innovation Challenges
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
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Research Scientist in Allergy
- Nestlé Research Center
- Lausanne, Switzerland
Instrumentation Engineering Leader
- Life Technologies
- Carlsbad, California
Progress Aneuploidy and cancer
Harith Rajagopalan1 & Christoph Lengauer1
Abstract
In contrast to normal cells, aneuploidy — alterations in the number of chromosomes — is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.
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