Table of contents
Volume 432 Number 7017 pp535-655
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Editorial
The e-developing world p535
Participants in an international forum last month were appropriately fired up about the opportunities for the poorest countries that are provided by information technologies. The attitudes of governments can make all the difference.
doi:10.1038/432535a
News
Suppressed study raises spectre of flawed drug regulation in US p537
FDA under pressure to reform after Vioxx is withdrawn.
Emma Marris
doi:10.1038/432537a
Europe breaks ranks over fusion project site p538
Fight over ITER puts 'big science' model in jeopardy.
Declan Butler
doi:10.1038/432538a
Scientists decry 'spy' verdict for Russian physicist p538
Russian sentenced to 14 years for passing "secrets" to China.
Bryon MacWilliams
doi:10.1038/432538b
Plans to track tuna canned amid claims of cash shortfall p539
Conservationists fear overfishing will kill off bluefin tuna.
Rex Dalton
doi:10.1038/432539a
Nuclear agreement paves way for fuel recycling in Japan p539
Uranium reprocessing plant set for trial runs early next year.
Ichiko Fuyuno
doi:10.1038/432539b
Croats protest that science minister is 'meddling' in MedILS p540
Appointments to Mediterranean institute are political, researchers complain.
Federica Castellani
doi:10.1038/432540a
Canada pledges cash for more victims of blood-bank debacle p540
Thousands of hepatitis C sufferers to get compensation.
David Spurgeon
doi:10.1038/432540b
Geneticists prepare for deluge of mutant mice p541
Catalogue of made-to-measure mouse models on the way.
Alison Abbott
doi:10.1038/432541a
News Features
Dispatches from the front line p544
Bad news travels fastest. Or so the scientists fighting disease hope. Since 1994, ProMED-mail has been reporting outbreaks as soon as they happen. Erika Check meets the team behind the 24-hour service.
doi:10.1038/432544a
David versus Goliath p546
Resources are shifting from small labs led by one researcher to large teams with expensive equipment. But has the rise of big biology gone too far? Erika Check investigates.
doi:10.1038/432546a
Correspondence
Tackling grade inflation in US universities p549
Solutions could include reporting the class average and ranking departments by results.
Craig D. Thulin
doi:10.1038/432549a
Grade inflation: students seek it, funders reward it p549
R. Ford Denison
doi:10.1038/432549b
Grade inflation keeps the customers happy p549
Stuart Rojstaczer
doi:10.1038/432549c
Journals must cooperate to defend biosecurity p549
Johannes Rath, Bernhard Jank and Otto Doblhoff-Dier
doi:10.1038/432549d
Commentary
The blame game p551
Who will pay for the damaging consequences of climate change?
doi:10.1038/432551a
Books and Arts
In from the cold p553
Mary Somerville's contribution to science has been undervalued.
Patricia Fara reviews Mary Somerville and the World of Science by Allan Chapman and Collected Works of Mary Somerville
doi:10.1038/432553a
A family affair p554
Walter Bodmer reviews Consanguinity, Inbreeding and Genetic Drift in Italy by Luigi Luca Cavalli-Sforza, Antonio Moroni and Gianna Zei
doi:10.1038/432554a
Science in culture p555
Peter Schouten's painting of Homo floresiensis.
Martin Kemp reviews
doi:10.1038/432555a
Burning questions p555
Ross Bradstock reviews Tending Fire: Coping with America's Wildland Fires by Stephen J. Pyne
doi:10.1038/432555b
New in paperback p556
doi:10.1038/432556a
Correction p556
doi:10.1038/432556b
Essay
Turning pointsWee beasties p557
How a tiny observation turned out to have a controlling influence.
Paul Nurse
doi:10.1038/432557a
News and Views
Climate change: Hot news from summer 2003 p559
The European heatwave of 2003: was it merely a rare meteorological event or a first glimpse of climate change to come? Probably both, is the answer, and the anthropogenic contribution can be quantified.
Christoph Schär and Gerd Jendritzky
doi:10.1038/432559a
Information science: Quantum errors corrected p560
The phrase 'quantum error correction' might sound like a technical fix to a device that ought to be working better. But it is in fact a fascinating piece of fundamental physics with powerful implications.
Andrew Steane
doi:10.1038/432560a
Archaeology: Greater expectations p561
Evidence of unexpected complexity in an ancient community in Uruguay is a further blow to the conventional view of prehistoric development in marginal areas of lowland South America.
Peter W. Stahl
doi:10.1038/432561a
50 years ago p561
doi:10.1038/432561b
Cytoskeleton: Spindle saga p563
It's generally been thought that, during cell division, only proteins are necessary to assemble the machine that segregates chromosomes. But a new molecular requirement has been discovered.
Eric Karsenti
doi:10.1038/432563a
Cell division: The heart of the cycle p564
To reproduce, cells must copy their genetic material and distribute the replicas into two daughter cells. A self-perpetuating molecular oscillator regulates periodic transitions between these two processes.
Jiri Lukas and Jiri Bartek
doi:10.1038/432564a
Cosmology: Neutrino probes of dark energy p567
Dark energy drives the accelerating expansion of the Universe — but what is dark energy? Its influence on the properties of neutrinos might be detectable, and could reveal something of its mysterious nature.
Gia Dvali
doi:10.1038/432567a
Cell biology: Clathrin's Achilles' ankle p568
The protein clathrin forms lattice-like coats on transport vesicles that bud from cell membranes. High-resolution models of the lattice reveal interactions involved in its disassembly once the vesicles have formed.
Frances M. Brodsky
doi:10.1038/432568a
Brief Communications
Palaeobiology: Argentinian unhatched pterosaur fossil p571
New pterosaur-egg features add to our understanding of these extinct flying reptiles.
Luis M. Chiappe, Laura Codorniú, Gerald Grellet-Tinner and David Rivarola
doi:10.1038/432571a
First paragraph | Full Text | PDF (397K) | Supplementary information
Palaeontology: Pterosaur egg with a leathery shell p572
Qiang Ji, Shu-An Ji, Yen-Nien Cheng, Hai-Lu You, Jun-Chang Lü, Yong-Qing Liu and Chong-Xi Yuan
doi:10.1038/432572a
First paragraph | Full Text | PDF (242K) | Supplementary information
Top of page
Brief Communications Arising
Atmospheric science: Tropospheric temperature series from satellites
Simon Tett and Peter Thorne
doi:10.1038/nature03208
First paragraph | Full Text | PDF (83K)
Atmospheric science: Stratospheric cooling and the troposphere
Nathan P. Gillett, Benjamin D. Santer and Andrew J. Weaver
doi:10.1038/nature03209
First paragraph | Full Text | PDF (103K)
Atmospheric science: Stratospheric cooling and the troposphere (reply)
Qiang Fu, Dian J. Seidel, Celeste M. Johanson and Stephen G. Warren
doi:10.1038/nature03210
First paragraph | Full Text | PDF (84K)
Articles
Molecular model for a complete clathrin lattice from electron cryomicroscopy p573
Alexander Fotin, Yifan Cheng, Piotr Sliz, Nikolaus Grigorieff, Stephen C. Harrison, Tomas Kirchhausen and Thomas Walz
doi:10.1038/nature03079
Abstract | Full Text | PDF (753K) | Supplementary information
A synaptic laminin–calcium channel interaction organizes active zones in motor nerve terminals p580
Hiroshi Nishimune, Joshua R. Sanes and Steven S. Carlson
doi:10.1038/nature03112
Abstract | Full Text | PDF (472K) | Supplementary information
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry p588
Michael Rape and Marc W. Kirschner
doi:10.1038/nature03023
Abstract | Full Text | PDF (554K) | Supplementary information
See also: News and Views by Lukas & Bartek
Letters to Nature
No cold dust within the supernova remnant Cassiopeia A p596
Oliver Krause, Stephan M. Birkmann, George H. Rieke, Dietrich Lemke, Ulrich Klaas, Dean C. Hines and Karl D. Gordon
doi:10.1038/nature03110
First paragraph | Full Text | PDF (543K)
Stellar encounters as the origin of distant Solar System objects in highly eccentric orbits p598
Scott J. Kenyon and Benjamin C. Bromley
doi:10.1038/nature03136
First paragraph | Full Text | PDF (321K)
Realization of quantum error correction p602
J. Chiaverini, D. Leibfried, T. Schaetz, M. D. Barrett, R. B. Blakestad, J. Britton, W. M. Itano, J. D. Jost, E. Knill, C. Langer, R. Ozeri and D. J. Wineland
doi:10.1038/nature03074
First paragraph | Full Text | PDF (373K)
See also: News and Views by Steane
Nonlinear optics in the extreme ultraviolet p605
Taro Sekikawa, Atsushi Kosuge, Teruto Kanai and Shuntaro Watanabe
doi:10.1038/nature03108
First paragraph | Full Text | PDF (4,114K)
Large fluctuations in speed on Greenland's Jakobshavn Isbræ glacier p608
Ian Joughin, Waleed Abdalati and Mark Fahnestock
doi:10.1038/nature03130
First paragraph | Full Text | PDF (392K)
Human contribution to the European heatwave of 2003 p610
Peter A. Stott, D. A. Stone and M. R. Allen
doi:10.1038/nature03089
First paragraph | Full Text | PDF (286K)
See also: News and Views by Schär & Jendritzky
Evidence for cultivar adoption and emerging complexity during the mid-Holocene in the La Plata basin p614
José Iriarte, Irene Holst, Oscar Marozzi, Claudia Listopad, Eduardo Alonso, Andrés Rinderknecht and Juan Montaña
doi:10.1038/nature02983
First paragraph | Full Text | PDF (667K) | Supplementary information
See also: News and Views by Stahl
Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I p618
Ivan Hrdy, Robert P. Hirt, Pavel Dolezal, Lucie Bardonová, Peter G. Foster, Jan Tachezy and T. Martin Embley
doi:10.1038/nature03149
First paragraph | Full Text | PDF (932K) | Supplementary information
A candidate NAD+ transporter in an intracellular bacterial symbiont related to Chlamydiae p622
Ilka Haferkamp, Stephan Schmitz-Esser, Nicole Linka, Claude Urbany, Astrid Collingro, Michael Wagner, Matthias Horn and H. Ekkehard Neuhaus
doi:10.1038/nature03131
First paragraph | Full Text | PDF (239K) | Supplementary information
Haemangioblast commitment is initiated in the primitive streak of the mouse embryo p625
Tara L. Huber, Valerie Kouskoff, H. Joerg Fehling, James Palis and Gordon Keller
doi:10.1038/nature03122
First paragraph | Full Text | PDF (379K)
The role of barren stalk1 in the architecture of maize p630
Andrea Gallavotti, Qiong Zhao, Junko Kyozuka, Robert B. Meeley, Matthew K. Ritter, John F. Doebley, M. Enrico Pè and Robert J. Schmidt
doi:10.1038/nature03148
First paragraph | Full Text | PDF (485K) | Supplementary information
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells p635
Ryan T. Phan and Riccardo Dalla-Favera
doi:10.1038/nature03147
First paragraph | Full Text | PDF (354K) | Supplementary information
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1 p640
Chaowei Wu, Irene Miloslavskaya, Silvia Demontis, Roberta Maestro and Konstantin Galaktionov
doi:10.1038/nature03173
First paragraph | Full Text | PDF (416K) | Supplementary information
Poly(ADP-ribose) is required for spindle assembly and structure p645
Paul Chang, Myron K. Jacobson and Timothy J. Mitchison
doi:10.1038/nature03061
First paragraph | Full Text | PDF (384K) | Supplementary information
See also: News and Views by Karsenti
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating p649
Alexander Fotin, Yifan Cheng, Nikolaus Grigorieff, Thomas Walz, Stephen C. Harrison and Tomas Kirchhausen
doi:10.1038/nature03078
First paragraph | Full Text | PDF (402K)
See also: News and Views by Brodsky
Corrigendum: The Ras–MAPK pathway is important for olfaction in Caenorhabditis elegans p653
Takaaki Hirotsu, Satoshi Saeki, Masayuki Yamamoto and Yuichi Iino
doi:10.1038/nature03169
Corrigendum: Contrasting origins of the upper mantle revealed by hafnium and lead isotopes from the Southeast Indian Ridge p653
Barry B. Hanan, Janne Blichert-Toft, Douglas G. Pyle and David M. Christie
doi:10.1038/nature03181
