Editorials

Small-minded government p169

Last week's debacle in New Orleans highlights failings not just in the Bush administration, but in how the United States chooses to govern itself.

doi: 10.1038/437169a

Full Text | PDF (96K)

Proteomics' new order p169

An international organization is finally bringing discipline to the study of cells' sets of proteins.

doi: 10.1038/437169b

Full Text | PDF (108K)

Endangered act p170

Efforts to reform the Endangered Species Act could harm America's most important conservation law.

doi: 10.1038/437170a

Full Text | PDF (74K)

Research Highlights

Research highlights p172

doi: 10.1038/437172a

Full Text | PDF (892K)

News

After the flood p174

Academic experts say they were all too aware of the devastation that would claim New Orleans and its surroundings in the wake of a fierce hurricane. Could they have done any more to convince politicians of the need to protect the city?

Tony Reichhardt, Erika Check and Emma Marris

doi: 10.1038/437174a

Full Text | PDF (338K)

Health centres and labs left reeling by Katrina p177

Hospital for New Orleans' poor hit hard.

Rex Dalton

doi: 10.1038/437177a

Full Text | PDF (228K)

Drug agency accused of political bias p179

Women's health director quits over 'morning after' pill delays

Meredith Wadman

doi: 10.1038/437179a

Full Text | PDF (294K)

Poles lose out as ozone levels begin to recover p179

Hole over Antarctica is third-largest recorded.

Quirin Schiermeier

doi: 10.1038/437179b

Full Text | PDF (294K)

Ecology is key to effective aid, UN told p180

Report recommends local management of natural resources.

Jim Giles

doi: 10.1038/437180a

Full Text | PDF (232K)

Budget plans hint at lean times ahead for Japanese research p181

Basic projects may face cutbacks.

Ichiko Fuyuno

doi: 10.1038/437181a

Full Text | PDF (197K)

Chernobyl: poverty and stress pose 'bigger threat' than radiation p181

Local communities suffer many effects of fall-out.

Valeska Stephan

doi: 10.1038/437181b

Full Text | PDF (198K)

News in brief p182

doi: 10.1038/437182a

Full Text | PDF (134K)

News Features

Stem-cell research: The rocky road to success p185

Tackling the legal and ethical minefield associated with human embryonic stem-cell research is not for the faint-hearted. Erika Check meets one man who is relishing the challenge.

doi: 10.1038/437185a

Full Text | PDF (562K)

Ornithology: A wing and a prayer p188

Sightings of the ivory-billed woodpecker, a bird believed extinct for 50 years, have fired the public's imagination. But is it really alive? Rex Dalton joins the team trying to save this elusive bird.

doi: 10.1038/437188a

Full Text | PDF (1,266K)

See also: Editor's summary

Business

Fears rise over leaks of clinical trial results p191

Doctors accused of selling drug secrets to market analysts.

Virginia Gewin

doi: 10.1038/437191a

Full Text | PDF (646K)

In brief p191

doi: 10.1038/437191b

Full Text | PDF (645K)

Correspondence

Cuban science democratic and not tied to profit p192

Catherine Badgley and Ivette Perfecto

doi: 10.1038/437192a

Full Text | PDF (110K)

Bioweapons could kill more in one strike than guns p192

Michael C. Wendl

doi: 10.1038/437192b

Full Text | PDF (113K)

EURYI scheme aims to stop women disappearing p192

Neil Williams

doi: 10.1038/437192c

Full Text | PDF (113K)

EURYI: present procedure risks conflicts of interest p192

Gábor Lente

doi: 10.1038/437192d

Full Text | PDF (113K)

Books and Arts

In our own hands p193

Biotechnology is changing the world, but why do nations respond so differently?

Mark Cantley reviews Designs on Nature: Science and Democracy in Europe and the United States by Sheila Jasanoff

doi: 10.1038/437193a

Full Text | PDF (502K)

See also: Editor's summary

A scientist's life in Russia p194

Alan L. Mackay reviews About Science, Myself and Others by V. L. Ginzburg

doi: 10.1038/437194a

Full Text | PDF (563K)

Families behaving badly p195

Jonathan Wright reviews A Natural History of Families by Scott Forbes

doi: 10.1038/437195a

Full Text | PDF (450K)

News and Views

Structural biology: Fibres hinge on swapped domains p197

When proteins assemble themselves into fibres, there can be grave pathological consequences. Designing an otherwise soluble protein to make fibres provides a general mechanism for the construction process.

Andrew D. Miranker

doi: 10.1038/437197a

Full Text | PDF (309K)

See also: Editor's summary

Biological physics: Rare returns on lost effort p198

How does the size of a system affect its thermodynamic irreversibility? A deft experiment that observes the unfolding and refolding of a single molecule of RNA provides insights into the question at a small scale.

Wesley P. Wong and Evan Evans

doi: 10.1038/437198a

Full Text | PDF (285K)

Evolutionary genetics: Microarrays and species origins p199

Whole-genome arrays have been used to reveal small islands of genetic differentiation in Anopheles mosquitoes. Analysis of these regions will identify genes involved in the initial stages of speciation.

Roger Butlin and Cally Roper

doi: 10.1038/437199a

Full Text | PDF (185K)

Synthetic chemistry: Glycosylation with a twist p201

Nature has a whole battery of dedicated enzymes to make the complex links between sugar rings — how can synthetic chemists compete? An ingenious approach fills a big gap in the synthetic tool-kit.

Sabine L. Flitsch

doi: 10.1038/437201a

Full Text | PDF (203K)

50 & 100 years ago p202

doi: 10.1038/437202a

Full Text | PDF (207K)

Molecular physiology: Intimate contact enables transport p203

Sodium-coupled neurotransmitter transporters are essential for neurons to communicate. The high-resolution crystal structure of a bacterial relative hints at how this family of transporters works.

Baruch I. Kanner

doi: 10.1038/437203a

Full Text | PDF (282K)

See also: Editor's summary

Environmental science: Carbon unlocked from soils p205

Changes in climate and land use are implicated as the main factors in the large-scale loss of carbon from soils in England and Wales over the past 25 years. The same picture is likely to apply much more broadly.

E. Detlef Schulze and Annette Freibauer

doi: 10.1038/437205a

Full Text | PDF (222K)

See also: Editor's summary

Physical chemistry: Isn't it ionic p206

Magdalena Helmer

doi: 10.1038/437206a

Full Text | PDF (146K)

Brief Communications

Behavioural endocrinology: No hormonal response in tied fights p207

Fish androgens may start to surge only when there seems to be a good chance of winning a contest.

Rui F. Oliveira, Luis A. Carneiro and Adelino V. M. Canário

doi: 10.1038/437207a

First paragraph | Full Text | PDF (269K)

See also: Editor's summary

Dynamical phenomena:  Walking and orbiting droplets p208

Y. Couder, S. Protière, E. Fort and A. Boudaoud

doi: 10.1038/437208a

First paragraph | Full Text | PDF (132K) | Supplementary information

Brief Communications Arising

Malaria risk: Estimating clinical episodes of malaria pE3

Bernard L. Nahlen, Eline L. Korenromp, John M. Miller and Kenji Shibuya

doi: 10.1038/nature04178

First paragraph | Full Text | PDF (90K)

Malaria risk: Estimation of the malaria burden pE3

David R. Bell, Pernille Jorgensen, Eva Maria Christophel and Kevin L. Palmer

doi: 10.1038/nature04179

First paragraph | Full Text | PDF (108K)

Malaria risk: Estimating clinical episodes of malaria (reply) pE4

Robert W. Snow, Carlos A. Guerra, Abdisalan M. Noor, Hly Y. Myint and Simon I. Hay

doi: 10.1038/nature04180

First paragraph | Full Text | PDF (98K)

Articles

Strategies for containing an emerging influenza pandemic in Southeast Asia p209

Neil M. Ferguson, Derek A.T. Cummings, Simon Cauchemez, Christophe Fraser, Steven Riley, Aronrag Meeyai, Sopon Iamsirithaworn and Donald S. Burke

doi: 10.1038/nature04017

Abstract | Full Text | PDF (498K) | Supplementary information

See also: Editor's summary | Authors

Crystal structure of a bacterial homologue of Na⁺/Cl^--dependent neurotransmitter transporters p215

Atsuko Yamashita, Satinder K. Singh, Toshimitsu Kawate, Yan Jin and Eric Gouaux

doi: 10.1038/nature03978

Abstract | Full Text | PDF (1,027K) | Supplementary information

See also: Editor's summary

Letters

Differentiation of the asteroid Ceres as revealed by its shape p224

P. C. Thomas, J. Wm. Parker, L. A. McFadden, C. T. Russell, S. A. Stern, M. V. Sykes and E. F. Young

doi: 10.1038/nature03938

First paragraph | Full Text | PDF (210K)

See also: Editor's summary

Wave acceleration of electrons in the Van Allen radiation belts p227

Richard B. Horne, Richard M. Thorne, Yuri Y. Shprits, Nigel P. Meredith, Sarah A. Glauert, Andy J. Smith, Shrikanth G. Kanekal, Daniel N. Baker, Mark J. Engebretson, Jennifer L. Posch, Maria Spasojevic, Umran S. Inan, Jolene S. Pickett and Pierrette M. E. Decreau

doi: 10.1038/nature03939

First paragraph | Full Text | PDF (681K) | Supplementary information

See also: Editor's summary

Verification of the Crooks fluctuation theorem and recovery of RNA folding free energies p231

D. Collin, F. Ritort, C. Jarzynski, S. B. Smith, I. Tinoco, Jr and C. Bustamante

doi: 10.1038/nature04061

First paragraph | Full Text | PDF (307K) | Supplementary information

See also: Authors

Ionic colloidal crystals of oppositely charged particles p235

Mirjam E. Leunissen, Christina G. Christova, Antti-Pekka Hynninen, C. Patrick Royall, Andrew I. Campbell, Arnout Imhof, Marjolein Dijkstra, René van Roij and Alfons van Blaaderen

doi: 10.1038/nature03946

First paragraph | Full Text | PDF (551K) | Supplementary information

Orbital forcing of Cretaceous river discharge in tropical Africa and ocean response p241

Britta Beckmann, Sascha Flögel, Peter Hofmann, Michael Schulz and Thomas Wagner

doi: 10.1038/nature03976

First paragraph | Full Text | PDF (337K) | Supplementary information

See also: Editor's summary

Carbon losses from all soils across England and Wales 1978−2003 p245

Pat H. Bellamy, Peter J. Loveland, R. Ian Bradley, R. Murray Lark and Guy J. D. Kirk

doi: 10.1038/nature04038

First paragraph | Full Text | PDF (319K) | Supplementary information

See also: Editor's summary

Geophysical evidence from the MELT area for compositional controls on oceanic plates p249

Rob. L. Evans, Greg Hirth, Kiyoshi Baba, Don Forsyth, Alan Chave and Randall Mackie

doi: 10.1038/nature04014

First paragraph | Full Text | PDF (229K) | Supplementary information

The effect of migration on local adaptation in a coevolving host−parasite system p253

Andrew D. Morgan, Sylvain Gandon and Angus Buckling

doi: 10.1038/nature03913

First paragraph | Full Text | PDF (232K) | Supplementary information

The most infectious prion protein particles p257

Jay R. Silveira, Gregory J. Raymond, Andrew G. Hughson, Richard E. Race, Valerie L. Sim, Stanley F. Hayes and Byron Caughey

doi: 10.1038/nature03989

First paragraph | Full Text | PDF (442K) | Supplementary information

See also: Editor's summary

Prion protein remodelling confers an immediate phenotypic switch p262

Prasanna Satpute-Krishnan and Tricia R. Serio

doi: 10.1038/nature03981

First paragraph | Full Text | PDF (343K) | Supplementary information

See also: Editor's summary

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure p266

Shilpa Sambashivan, Yanshun Liu, Michael R. Sawaya, Mari Gingery and David Eisenberg

doi: 10.1038/nature03916

First paragraph | Full Text | PDF (357K) | Supplementary information

See also: Editor's summary | Authors

Mutations in NOTCH1 cause aortic valve disease p270

Vidu Garg, Alecia N. Muth, Joshua F. Ransom, Marie K. Schluterman, Robert Barnes, Isabelle N. King, Paul D. Grossfeld and Deepak Srivastava

doi: 10.1038/nature03940

First paragraph | Full Text | PDF (425K) | Supplementary information

See also: Editor's summary

Asymmetric cell divisions promote stratification and differentiation of mammalian skin p275

Terry Lechler and Elaine Fuchs

doi: 10.1038/nature03922

First paragraph | Full Text | PDF (490K) | Supplementary information

See also: Editor's summary

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development p281

Abdolrahman S. Nateri, Bradley Spencer-Dene and Axel Behrens

doi: 10.1038/nature03914

First paragraph | Full Text | PDF (407K) | Supplementary information

See also: Editor's summary

A mechanistic principle for proton pumping by cytochrome c oxidase p286

Kristina Faxén, Gwen Gilderson, Pia Ädelroth and Peter Brzezinski

doi: 10.1038/nature03921

First paragraph | Full Text | PDF (276K)

See also: Editor's summary

Erratum: In situ multi-satellite detection of coherent vortices as a manifestation of Alfvénic turbulence p290

David Sundkvist, Vladimir Krasnoselskikh, Padma K. Shukla, Andris Vaivads, Mats André, Stephan Buchert and Henri Rème

doi: 10.1038/nature04144

Full Text | PDF (53K)

Erratum: Evasion of intracellular host defence by hepatitis C virus p290

Michael Gale, Jr and Eileen M. Foy

doi: 10.1038/nature04145

Full Text | PDF (53K)

Corrigendum: Action potential refractory period in ureter smooth muscle is set by Ca sparks and BK channels p290

T. Burdyga and Susan Wray

doi: 10.1038/nature04146

Full Text | PDF (53K)

Naturejobs

Breathing life into industry p291

Regional programme offers biotech training to life-science graduates

Paul Smaglik

doi:10.1038/nj7056-291a

Full Text | PDF (117K)

Brian Foster, European regional director, International Linear Collider's Global Design Effort, Oxford, UK p292

Physicist takes on large collider project

Janet Wright

doi:10.1038/nj7056-292a

Full Text | PDF (108K)

Scientists & Societies p292

Young European scientists form research training networks

Alessandro Sartori

doi:10.1038/nj7056-292b

Full Text | PDF (109K)

Graduate Journal:  Dualities p292

Graduate learns to live with positives and negatives of her decisions

Karolina Tkaczuk

doi:10.1038/nj7056-292c

Full Text | PDF (109K)

Futures

Not at home to visitors p294

They're big, but they're not clever.

Janet Wright

doi: 10.1038/437294a

Full Text | PDF (215K)