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Nature 438, 899 (15 December 2005) | doi:10.1038/438899b; Published online 14 December 2005

Open Innovation Challenges

Journal grows suspicious of Vioxx data

Meredith Wadman

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Editors express concern over paper's conclusions.

The integrity of a key study of the painkiller Vioxx has been questioned by the New England Journal of Medicine, which published the work in 2000. Vioxx was taken off the market last year because of evidence that it increased patients' risk of having a heart attack or stroke.