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Nature 446, 1038-1045 (26 April 2007) | doi:10.1038/nature05818; Published online 25 April 2007
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
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Research Scientist for Analytical Development
- Novo Nordisk
- Bagsværd, Denmark
Director of Surgical Pathology
- Vanderbilt University
- Nashville, Tennessee, USA
Exploiting the defensive sugars of HIV-1 for drug and vaccine design
Christopher N. Scanlan1, John Offer2, Nicole Zitzmann1 & Raymond A. Dwek1
Abstract
The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.
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